Value of shear wave elastography by virtual touch tissue imaging quantification in  patients with diffuse thyroid gland pathology

Rahatli, Feride Kural; Turnaoğlu, Hale; Kirnap, Nazlı Gülsoy; İyidir, Özlem Turhan; Haberal, Kemal Murat; Soudmand, Aresh; Uslu, Nihal

doi:10.3906/sag-1803-235

Cited by 8 publications

(11 citation statements)

References 16 publications

(22 reference statements)

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“…The mean SWE values ± SDs of patients with GD were found to be between 17.6 ± 6.4 and 27.05 ± 12.21 kPa 16,18 and between 2.61 ± 0.32 and 2.71 ± 0.22 m/s 20,21 in previous studies. The mean SWE values of control groups consisting of adult participants were found to be between 10.97 ± 3.1 and 14.3 ± 2.7 kPa 16–18 and between 1.63 ± 0.12 and 1.92 ± 0.14 m/s 8,20,21 …”

Section: Discussionmentioning

confidence: 93%

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Evaluation of the Stiffness of Thyroid Parenchyma With Shear Wave Elastography Using a Free–Region of Interest Technique in Graves Disease

Kılınçer

Durmaz

Baldane

et al. 2020

J of Ultrasound Medicine

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Objectives The first aim was to evaluate the stiffness of thyroid parenchyma with shear wave elastography (SWE) in patients with Graves disease (GD) and compare the elastographic values with those of asymptomatic volunteers. The second aim was to evaluate whether there was a correlation between SWE values and grayscale ultrasound (US) and laboratory parameters. Methods In this prospective study, the thyroid gland parenchyma of 50 patients whose clinical and laboratory findings were indicative for GD and 54 asymptomatic participants with normal laboratory values was examined by SWE. Grayscale US images of the thyroid and submandibular gland were recorded. The volume of the thyroid gland was measured. Elastographic measurements were performed with a free region of interest. The quantitative SWE values (meters per second and kilopascals) of the patient and control groups were compared. A correlation analysis between the SWE values and grayscale US and laboratory parameters was performed. Results The median (range) SWE values of the thyroid gland in patients with GD were significantly higher than those of the control group [17.34 (12.58–56.15) versus 12.05 (7.72–23.67) kPa and 2.28 (1.83–4.12) versus 1.92 (1.55–2.61) m/s; P < .001 for both comparisons]. When 14.5 kPa or 2.115 m/s was designated as the cutoff value, GD could be diagnosed with a high sensitivity and specificity. We showed a negative weak correlation between the SWE values and parenchymal echogenicity in the GD group. Conclusions Shear wave elastography can be used as an effective imaging method with high sensitivity and specificity rates in the diagnosis of GD.

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Section: Discussionmentioning

confidence: 93%

“…In studies evaluating thyroid parenchyma using SWE, the quantitative elasticity values were measured only as kilopascals 16–18 or only as meters per second 8,19–21 . In a limited number of studies, the quantitative elasticity values were measured as both meters per second and kilopascals 14 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Stiffness of Thyroid Parenchyma With Shear Wave Elastography Using a Free–Region of Interest Technique in Graves Disease

Kılınçer

Durmaz

Baldane

et al. 2020

J of Ultrasound Medicine

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“…Sporea et al [25] compared the SWV among 29 patients with GD, 22 patients with CAT, and 23 control subjects and found a significantly higher SWV in the GD than in the CAT group (2.82 ± 0.47 vs. 2.49 ± 0.48 m/s, respectively). Furthermore, Rahatli et al [26] in a study included 30 patients with HT and 22 patients with GD found patients with GD had significantly higher shear wave velocities than those with HT ( P < 0.001). The difference between the results of current study and these two studies may be due to difference in number of the patients, and the fact that most of patients with HT included in the study was in chronic stage.…”

Section: Discussionmentioning

confidence: 99%

Value of the New Elastography Technique using Acoustic Radiation Force Impulse in Differentiation between Hashimoto’s Thyroiditis and Graves’ Disease

Hefeda

2019

JCIS

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Background and Aim: This study was performed to evaluate the role and accuracy of shear wave elastography in the differentiation between Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), in comparison with the B-mode ultrasound and color Doppler ultrasound. Materials and Methods: This study was non-randomized prospective study. The study included 30 patients with GD, 65 patients with HT, and 35 patients with normal thyroid glands. Assessment of ultrasonographic criteria, color Doppler flow pattern, and shear patterns differed significantly between the control group and the group of diffuse thyroid disease (P < 0.001). The most specific sign for diagnosing HT was nodularity (97.87%), and the most sensitive sign was coarse echotexture (81.54%). Color Doppler flow (CDF) showed sensitivity of 91.8%, specificity of 56.92%, positive predictive value of 52.54%, negative predictive value of 92.5%, and diagnostic accuracy of 68.69% in the differentiation between GD and HT. The mean shear wave velocity (SWV) was 2.61 ± 0.32 m/s in the GD group (range: 2.1–3.21 m/s), 2.85 ± 0.52 m/s in the HT group (range: 2.31–3.82 m/s), and 1.75 ± 0.37 m/s in the control group (range: 1.24–2.36 m/s). The mean SWVs in the GD and HT groups were significantly higher than that in the control group (P < 0.001). The mean SWV in the HT group was higher than that in the GD group (P = 0.03). Conclusion: Quantitative and qualitative SWE is useful for diagnosing diffuse thyroid disease and evaluating the degree of fibrosis in autoimmune thyroiditis. However, acoustic radiation force impulse techniques cannot differentiate between HT and GD reliably.

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“…Most studies on the role of SWE in the thyroid disease have been focused on nodules so far. There is only a limited number of studies concerning SWE in diffuse thyroid disease [4][5][6][7][8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

“…List of publications comparing mean stiffnesses of normal thyroid and in diffuse thyroid disease[4][5][6][7][8][9][10][11][12] . DTD diffuse thyroid disease; N° number of healthy volunteers/number of patients, RL right lobe, LL left lobe; grey numbers are approximate values calculated with the formula Young's modulus…”

mentioning

confidence: 99%

Shear wave elastography in diffuse thyroid disease

Sedláčková¹,

Herman²,

Fürst³

et al. 2021

BIOMED PAP

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Aim. Our aim was to examine the contribution of shear wave elastography to ultrasonographic assessment in diffuse thyroid disease, specifically to evaluate the stiffness of the thyroid gland in diffuse thyroid disease and compare it with healthy controls. Methods. A total of 46 patients with diffuse thyroid disease were examined clinically, by conventional ultrasound, and shear wave elastography. The conventional ultrasound parameters followed were: volume, margin quality, presence of nodules, and vascularisation. We measured the mean, minimum, and maximum stiffnesses by shear wave elastography. Results were correlated with values in 128 healthy subjects. Results. Patients with diffuse thyroid disease had significantly higher mean and maximal stiffnesses of the thyroid gland: 12.5 ± 5 kPa and 35.3 ± 12.8 kPa, respectively, and lower minimal stiffness: 0.5 ± 0.6 kPa than the healthy control group with mean, maximal, and minimal values of 9.5 ± 3.6 kPa, 22.5 ± 7.3 kPa, and 2.2 ± 2.1 kPa (P<0.001). Stiffness values were positively correlated with BMI and volume of the thyroid; they did not correlate with margin quality, presence of nodules nor vascularisation. Compared with healthy volunteers, thyroid glands of patients with diffuse thyroid disease had a blurred margin more frequently and the amount of nodules and vascularisation were higher. Patients with Graves-Basedow disease did not have significantly different mean, maximal, nor minimal stiffnesses than those with thyroiditis. Conclusion. Both mean and maximal stiffness of the thyroid gland are significantly higher in diffuse thyroid disease than in the healthy population, while minimal stiffness is lower.

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Value of shear wave elastography by virtual touch tissue imaging quantification in patients with diffuse thyroid gland pathology

Cited by 8 publications

References 16 publications

Evaluation of the Stiffness of Thyroid Parenchyma With Shear Wave Elastography Using a Free–Region of Interest Technique in Graves Disease

Evaluation of the Stiffness of Thyroid Parenchyma With Shear Wave Elastography Using a Free–Region of Interest Technique in Graves Disease

Value of the New Elastography Technique using Acoustic Radiation Force Impulse in Differentiation between Hashimoto’s Thyroiditis and Graves’ Disease

Shear wave elastography in diffuse thyroid disease

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