Value of Serum Cholinesterase Activity in the Diagnosis of Septic Shock Due to Bacterial Infections

Bahloul, Mabrouk; Baccouch, Najeh; Chtara, Kamilia; Turki, Mouna; Turki, Olfa; Hamida, Chokri Ben; Chelly, Hédi; Ayedi, Fatma; Chaari, Anis; Bouaziz, Mounir

doi:10.1177/0885066616636549

Cited by 31 publications

(44 citation statements)

References 26 publications

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“…In conclusion, BChE activity can be regarded as a biomarker in PD, especially in PD-related dementia. The same function has also been reported in other disorders, including Alzheimer's disease [ 11 ], vascular dementia [ 25 ], ischemic stroke [ 26 ], traumatic brain injury [ 7 ], postoperative delirium [ 27 ], severe trauma [ 28 ], septic shock [ 29 ], burn injuries [ 30 ], adverse cardiac events [ 16 ], hepatic disease [ 17 ], diabetes [ 31 ], and hyperlipidemia [ 32 ]. A former study on AChE levels in PD patients suggested that polymorphisms in ACHE genes fail to initiate ACHE expression, resulting in an impaired Ach/DA balance and subsequent vulnerability of dopaminergic neurons and PD development [ 9 ].…”

Section: Discussionsupporting

confidence: 57%

Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Dong

et al. 2017

BioMed Research International

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Objective This study aim to determine changes of serum butyrylcholinesterase (BChE) activity in PD patients and related dementia. Patients and Methods Consecutive PD patients and healthy controls were included and clinical data were collected. Fast serum BChE activity was determined and compared between healthy controls and PD patients. Independent risk factors were performed for BChE activity, PD, and related dementia. The relationship between BChE activity and disease severity was also evaluated. Receiver operating characteristic (ROC) curves were obtained to explore serum BChE activity in distinguishing PD patients and related dementia. Results Serum BChE activity mainly independently correlated with gender, albumin, triglyceride, body mass index, and PD. Serum BChE activity decreased in PD patients compared with healthy controls. Based on the ROC curve, the optimal cut-off point was 6864.08 IU/L for distinguishing PD patients, and the sensitivity and specificity values were 61.8% and 72.1%. It inversely correlated with Unified Parkinson's Disease Rating Scale score. BChE activity decreased in PD-related dementia compared with those without dementia. The sensitivity and specificity values were 70.6% and 76.3%, respectively, with an optimal cut-off point of 6550.00 IU/L. Conclusions Serum BChE activity can be regarded as a biomarker for PD and related dementia.

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Section: Discussionsupporting

confidence: 57%

Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Dong

et al. 2017

BioMed Research International

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“…As the function of the diaphragm during sepsis is often severely impaired,[ 5 ] it is of great importance to fully reverse the residual neuromuscular block in septic patients. Sepsis decreased the activity of serum pseudocholinesterase;[ 6 7 ] however, to the best of our knowledge, the changes of AChE activity in the NMJ during sepsis have few directly investigated to date. One pharmacological study investigated the dose-response curves of anticholinesterase drugs and showed that the antagonistic actions of anticholinesterase drugs were weakened during sepsis.…”

Section: Introductionmentioning

confidence: 99%

Sepsis Strengthens Antagonistic Actions of Neostigmine on Rocuronium in a Rat Model of Cecal Ligation and Puncture

Tian

Wang

et al. 2016

Chinese Medical Journal

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Background:The antagonistic actions of anticholinesterase drugs on non-depolarizing muscle relaxants are theoretically related to the activity of acetylcholinesterase (AChE) in the neuromuscular junction (NMJ). However, till date the changes of AChE activity in the NMJ during sepsis have not been directly investigated. We aimed to investigate the effects of sepsis on the antagonistic actions of neostigmine on rocuronium (Roc) and the underlying changes of AChE activity in the NMJ in a rat model of cecal ligation and puncture (CLP).Methods:A total of 28 male adult Sprague-Dawley rats were randomized to undergo a sham surgery (the sham group, n = 12) or CLP (the septic group, n = 16). After 24 h, the time-response curves of the antagonistic actions of 0.1 or 0.5 μmol/L of neostigmine on Roc (10 μmol/L)-depressed diaphragm twitch tension were measured. Meanwhile, the activity of AChE in the NMJ was detected using a modified Karnovsky and Roots method. The mRNA levels of the primary transcript and the type T transcript of AChE (AChET) in the diaphragm were determined by real-time reverse transcription-polymerase chain reaction.Results:Four of 16 rats in the septic group died within 24 h. The time-response curves of both two concentrations of neostigmine in the septic group showed significant upward shifts from those in the sham group (P < 0.001 for 0.1 μmol/L; P = 0.009 for 0.5 μmol/L). Meanwhile, the average optical density of AChE in the NMJ in the septic group was significantly lower than that in the sham group (0.517 ± 0.045 vs. 1.047 ± 0.087, P < 0.001). The AChE and AChET mRNA expression levels in the septic group were significantly lower than those in the sham group (P = 0.002 for AChE; P = 0.001 for AChET).Conclusions:Sepsis strengthened the antagonistic actions of neostigmine on Roc-depressed twitch tension of the diaphragm by inhibiting the activity of AChE in the NMJ. The reduced content of AChE might be one of the possible causes of the decreased AChE activity in the NMJ.

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“…La actividad de la acetilcolinesterasa puede ser utilizada como biomarcador en el diagnóstico de sepsis debido a infecciones bacterianas, observándose una disminución en pacientes con choque séptico. 5 Además, se ha evaluado el valor pronóstico de la acetilcolinesterasa junto con la escala APACHE II en pacientes con sepsis, 6 encontrándose valores similares en predicción de resultados. La utilidad de la actividad de acetilcolinesterasa está directamente relacionada con el aumento de la infl amación secundaria a sepsis, por lo que puede ser una herramienta útil en el diagnóstico y predicción de esta patología.…”

Section: Discussionunclassified

“…En el estudio de Bahloul 5 se encontró un menor nivel de acetilcolinesterasa en los pacientes sépticos (2,923 ± 931 U/L versus 3,386 ± 1,604 U/L); probablemente se deba a que los pacientes incluidos presentaban diferentes características en comparación con los nuestros, ya que aparentemente en este estudio se encontraban más graves, determinados por el valor de SOFA (8.28 ± 3.5 versus 2 [2][3][4][5]), SIRS (100 versus 16.7%), uso de vasopresores (61 versus 25%) y ventilación mecánica invasiva (72 versus 25%). También los niveles de biomarcadores se encontraron muy diferentes, encontrándose mayor elevación de la procalcitonina (25.8 ± 36 versus 1.93 [1.00-7.87]) y PCR (182 ± 124 versus 15.75 [0.11-18.70]) en ese estudio.…”

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Los niveles de acetilcolinesterasa en pacientes con inestabilidad hemodinámica descartan sepsis como causa de choque

Zepeda¹,

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Palma³

et al. 2018

Medicina Crítica

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Resultados: Foram avaliados 44 pacientes, 27% com sepse. Os valores de acetilcolinesterase apresentaram validade diagnóstica para predizer sepse (AUC: 0.852 IC 95%: 0.726-0.977, p < 0.001), com valor de corte 3956 U/L, sensibilidade = 81%, especifi cidade = 75%. O valor de neutrófi los com um corte < 74% também teve um valor preditivo de sepsis (AUC: 0.710 IC 95%: 0.512-0.907, p = 0.034) sensibilidade = 75%, especifi cidade = 75%. Conclusões: Em pacientes com instabilidade hemodinâmica com níveis de acetilcolinesterase superiores a 4,000 U/L a sepse é descartada como causa de choque.

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Value of Serum Cholinesterase Activity in the Diagnosis of Septic Shock Due to Bacterial Infections

Abstract: The SChE activity level was significantly decreased in patients with septic shock. However, its prognostic value is poor. Our results suggest that SChE activity is useful for the diagnosis of septic shock. Further studies are warranted to confirm our findings.

Cited by 31 publications

References 26 publications

Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Sepsis Strengthens Antagonistic Actions of Neostigmine on Rocuronium in a Rat Model of Cecal Ligation and Puncture

Los niveles de acetilcolinesterasa en pacientes con inestabilidad hemodinámica descartan sepsis como causa de choque

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