Value of serum brain-derived neurotrophic factor and glial fibrillary acidic protein for detecting depression in patients with Helicobacter pylori infection

Zhao, En; Yu, Qian; Wang, Meilei; Wang, Zhengqiu; Jiang, Bin; Ma, Xiang; Zhou, Bin; Dai, Qingyong; Li, Jinyu; Wang, Shiming; Chen, Fengjuan; Yang, Xiaojun

doi:10.1016/j.neulet.2024.137687

Cited by 1 publication

(1 citation statement)

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“…Furthermore, the mediation analysis in LVO patients could determine whether environmental factors mediated the association between the relative abundance of gut microbiota on the severity of stroke based on a standard three-variable mediation model 44 , 45 . Line regression was used to evaluate the interaction between two variables on the functional outcome 46 , 47 . Changed value = admission score − discharge score.…”

Section: Methodsmentioning

confidence: 99%

Identifying gut microbiota with high specificity for ischemic stroke with large vessel occlusion

He,

Jiang,

et al. 2024

Sci Rep

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Gut microbiota can regulate the metabolic and immunological aspects of ischemic stroke and modulate the treatment effects. The present study aimed to identify specific changes in gut microbiota in patients with large vessel occlusion (LVO) ischemic stroke and assess the potential association between gut microbiota and clinical features of ischemic stroke. A total of 63 CSVD patients, 64 cerebral small vessel disease (CSVD) patients, and 36 matching normal controls (NCs) were included in this study. The fecal samples were collected for all participants and analyzed for gut microbiota using 16S rRNA gene sequencing technology. The abundances of five gut microbiota, including genera Bifidobacterium, Butyricimonas, Blautia, and Dorea and species Bifidobacterium_longum, showed significant changes with high specificity in the LVO patients as compared to the NCs and CSVD patients. In LVO patients, the genera Bifidobacterium and Blautia and species Bifidobacterium_longum were significantly correlated with the National Institutes of Health Stroke Scale (NIHSS) scores at the admission and discharge of the patients. Serum triglyceride levels could significantly affect the association of the abundance of genus Bifidobacterium and species Bifidobacterium_longum with the NIHSS scores at admission and modified Rankin Scale (mRS) at discharge in LVO patients. The identification of five gut microbiota with high specificity were identified in the early stage of LVO stroke, which contributed to performed an effective clinical management for LVO ischemic stroke.

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