Value of Schwangerschaftsprotein 1 (SP₁) and pregnancy‐associated plasma protein‐A (PAPP‐A) in the clinical management of threatened abortion

Abstract

Summary. Pregnancy‐associated plasma protein‐A (PAPP‐A) and Schwangerschaftsprotein 1 (SP1) levels were measured in single serum samples from 60 patients admitted with vaginal bleeding in the first 14 weeks of pregnancy. When based on ultrasound diagnoses the prediction of non‐viability (the predictive value) was 97% for SP1 and 84% for PAPP‐A. Whereas the prediction of viability (above –2SD of the normal range) with SP1 was 88% the value with PAPP‐A was only 57%; the poorer result obtained with PAPP‐A probably reflects its longer half‐life. Pregnancy outcome is not related to the duration of bleeding.

Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence

“…The majority of PSG functional studies have focused on determining whether PSGs are able to modulate the maternal immune system to prevent rejection of the allotypic fetus. In fact, low PSG levels in the maternal circulation are associated with threatened abortions, intrauterine growth retardation and fetal hypoxia (Wurz et al 1981;Tamsen et al 1983;MacDonald et al 1983;Masson et al 1983).…”

In vivo expression of recombinant pregnancy‐specific glycoprotein 1a induces alternative activation of monocytes and enhances Th2‐type immune response

“…PSG seems to be essential for successful pregnancy, since low levels of these glycoproteins are associated with spontaneous abortion, intrauterine growth retardation and preeclampsia [13,14]. Previously, we demonstrated that mammalian cells infected "in vitro" with a vaccinia virusbased vector harboring the open reading frame of human PSG1a cDNA release high concentrations of an N-glycosylated 72-kDa PSG1a protein (rec-PSG1a) to the culture supernatant, like that secreted by human placenta [15].…”

Role of the Transcription Factor C/EBPβ in Expression of a Rat Pregnancy-Specific Glycoprotein Gene

“…The rnCGM3 PI promoter concessful pregnancies. Low PSG values are associated with poor tains a TATA box which is absent from the PSG and CEA genes pregnancy outcome (Würz et al, 1981;Masson et al, 1983), so far characterized (Schrewe et al, 1990;Lei et al, 1992b, intrauterine growth retardation (Tamsen et al, 1983), and fetal 1993; Chamberlin et al, 1994). Two activator elements, PISI hypoxia (MacDonald et al, 1983).…”