“…If algorithms can reliably identify cancer cells on HE‐stained sections, this may save the high costs of immunohistochemistry, such as keratin stains on sentinel lymph nodes for breast of cervix carcinoma, 41 prostate biopsies, 41 or in identifying intrahepatic cholangiocarcinoma from colorectal liver metastases 42 . For example, in the UMC Utrecht, where HE slides of sentinel lymph nodes are assessed first, and stains are requested when these slides are morphologically negative, we spent over €30,000 on keratin stains for sentinel lymph node assessment in approximately 180 breast cancer patients.…”