Value of Prostate-Specific Antigen in the Staging of Taiwanese Patients With Newly Diagnosed Prostate Cancer

Meng, En; Sun, Guang; Wu, Sing-Yung; Chuang, Fu-Kai; Lee, S.-S.; Yü, Dah‐Shyong; Yen, Che-Hung; Chen, H.-I.; Chang, Shin-Tsu

doi:10.1080/01485010390249971

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…29 Similar genetic models have been used to study the role of the autonomic nervous system in prostate cancer with Hi-Myc transgenic mice that develop prostate cancer similar to human tumors. 30,31 To date, these models have been most helpful in elucidating the contribution of the nervous system to the development and progression of cancer and less to understanding the basic biology of PNI. The clear benefit of these systems is that the nerve microenvironment remains intact and the cancer naturally invades the nerves as opposed to orthotopic or heterotopic models in which the cancer and PNI develop iatrogenically.…”

Section: Carcinogenesis-induced Modelsmentioning

confidence: 99%

Mechanisms of Perineural Invasion

Bakst

Wong

2016

J Neurol Surg B

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Perineural invasion (PNI) is the neoplastic invasion of nerves. PNI is widely recognized as an important adverse pathological feature of many malignancies, including pancreatic, prostate, and head and neck cancers and is associated with a poor prognosis. Despite widespread acknowledgment of the clinical significance of PNI, the mechanisms underlying its pathogenesis remain largely unknown. Recent theories of PNI pathogenesis have placed a significant emphasis on the active role of the nerve microenvironment, with PNI resulting from well-orchestrated reciprocal interactions between cancer and host. Elucidating the mechanisms involved in PNI may translate into targeted therapies for this ominous process.

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Section: Carcinogenesis-induced Modelsmentioning

confidence: 99%

Mechanisms of Perineural Invasion

Bakst

Wong

2016

J Neurol Surg B

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“…Prostate cancer exhibits tremendous difference in incidence in different populations worldwide. Asian men typically have a very low incidence and mortality of CaP in contrast to northern european, african and American popu lations [1,2]. There is doubt whether the behaviour of CaP in the African population is different from that in western countries.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that there is a wide geographic variation in the incidence of clinical prostate cancer. In the african population, the incidence and mortality rates of CaP are strikingly higher than that in chinese or caucasians ethnies [1,2]. There is evidence that genetic, environmental and social factors jointly, often in combination, contribute to the observed differences in various populations.…”

Section: Introductionmentioning

confidence: 99%