Value of Platelet Function Testing in Monitoring Platelet Substitution

Abstract

The use of platelet transfusion in the prevention and treatment of bleeding complications is still fiercely debated. To date, transfusions are usually monitored by measuring the post-transfusion platelet count and/or the corrected count increment. However, an increase in the platelet count does not necessarily correspond to an improvement in primary haemostasis. Although the response to platelet transfusions can be somewhat assessed by the physician treating the affected patient, the real effect remains frequently questionable. This review describes and discusses platelet function assays that might be used in the assessment of platelet transfusions.

Cellular Haemostaseology II – Impact of Platelet Function Testing for Coagulation Management and Platelet Substitution Therapy

“…Beyond these diagnostic applications, the forthcoming use of platelets as therapeutic deliverables in novel treatment approaches addressing cellular haemostasis by platelet-directed gene therapy is discussed. The thorough review by Oliver Meyer, Holger Kiesewetter and Abdulgabar Salama [1] provides a precise analysis of the procurable evidence to use platelet function tests to monitor substitution with platelet concentrates. The currently available methods for analysis of platelet function are critically evaluated regarding their practical use to steer therapeutic and prophylactic use of platelet concentrates and to direct timing of platelet concentrate application.…”