Value of Plasma Pepsinogen Estimation

Edwards, Kathleen; Jepson, R. P.; Wood, Keith

doi:10.1136/bmj.1.5165.30

Cited by 84 publications

(15 citation statements)

References 8 publications

(7 reference statements)

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“…Although several groups of workers (Mirsky et al, 1952;Sievers and Fischer, 1957;Nolan, 1958;van Goidsenhoven, Wilkoff, and Kirsner, 1958;Edwards et al, 1960;Vickers and Kennedy, 1962) have shown that the estimation of the serum pepsinogen level is of little value in the differentiation between patients proven to have duodenal ulceration and those patients with suggestive symptoms in whom no ulcer could be demonstrated, our results indicate that the serum pepsinogen estimation might be a useful method for studying the prevalence of severe atrophic gastritis, gastric atrophy, pernicious anaemia, and latent pernicious anaemia. One venepuncture, to which most people would agree, would provide the blood for haemoglobin, serum pepsinogen, and serum vitamin B12 estimations.…”

Section: Discussionmentioning

confidence: 99%

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The serum pepsinogen level with special reference to the histology of the gastric mucosa

Böck¹,

Arapakis²,

Witts³

et al. 1963

Gut

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Section: Discussionmentioning

confidence: 99%

“…HCI) secreted in one hour after augmented histamine stimulation. SERUM PEPSINOGEN LEVEL The method used for estimating the serum pepsinogen level was a modification of that described by Edwards, Jepson, and Wood (1960). Serum was added to the substrate (dehydrated human plasma) and the acidity of the mixture adjusted to pH 1-5 to 2-0.…”

mentioning

confidence: 99%

The serum pepsinogen level with special reference to the histology of the gastric mucosa

Böck¹,

Arapakis²,

Witts³

et al. 1963

Gut

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“…The serum Peps level, which is an indicator of gastric damage associated with the progression of larvae to the adult stage (Murray et al, 1970), was measured by fluorometric determination in a 96-well microtitre plate using the adapted technique from Edwards et al (1960).…”

Section: Sampled Animals and Measurementsmentioning

confidence: 99%

Genetic parameters for resistance to trichostrongylid infection in dairy sheep

Gutiérrez-Gil

Pérez

Fuente

et al. 2010

Animal

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In sheep, the traditional chemical control of gastrointestinal nematode (GIN) parasites with anthelmintics has led to the widespread development of anthelmintic resistance. The selection of sheep with enhanced resistance to GIN parasites has been suggested as an alternative strategy to develop sustainable control of parasite infections. Most of the estimations of the genetic parameters for sheep resistance to GIN parasites have been obtained from young animals belonging to meat-and/or wool-specialised breeds. We present here the estimated genetic parameters for four parasite resistance traits studied in a commercial population of adult Spanish Churra dairy ewes. These involved two faecal egg counts (FECs) (LFEC 0 and LFEC 1 ) and two serum indicator traits, the anti-Teladorsagia circumcincta fourth stage larvae IgA (IgA) and the pepsinogen (Peps) levels. In addition, this study has allowed us to identify the environmental factors influencing parasite resistance in naturally infected Spanish Churra sheep and to quantify the genetic component of this complex phenotype. The heritabilities estimated for the two FECs analysed (0.12 for LFEC 0 and 0.09 for LFEC 1 ) were lower than those obtained for the examined serum indicators (0.19 for IgA and 0.21 for Peps). The genetic correlations between the traits ranged from 0.43 (Peps2IgA) to 0.82 ( LFEC 0 2LFEC 1 ) and were higher than their phenotypic counterparts, which ranged between 0.07 and 0.10. The heritabilities estimated for the studied traits were lower than previously reported in lambs. This may be due to the differences in the immune mechanisms controlling the infection in young (antibody reactions) and adult (hypersensitivity reactions) animals/sheep. In summary, this study demonstrates the presence of heritable variation in parasite resistance indicator traits in the Churra population studied, which suggests that genetic improvement is feasible for this complex trait in this population. However, further studies in which the experimental variables are controlled as much as possible are needed to identify the best trait that could be measured routinely in adult sheep as an indicator of parasite resistance.

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“…The serum pepsinogen value was measured by the colorimetric method of Edwards et al (1960) with modifications (Mylrea & Hotson, 1969;Berghen et al, 1987). Plasma was added to a substrate mixture (0.9 % bovine albumin fraction V in glycine buffer, pH 2.0) and mixed thoroughly.…”

Section: Blood Samples and Analysesmentioning

confidence: 99%

Diagnostic and prognostic significance of serum gastrin and pepsinogen in dairy cows with displaced abomasum

Khalphallah¹,

Elmeligy²,

Aamer³

et al. 2018

BJVM

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The study aimed to describe the changes in clinical findings and serum levels of gastrin, pepsinogen and chloride (Cl) in dairy cattle with displacement of the abomasum (DA) from day 0 until day 30 after surgery and to evaluate their diagnostic and prognostic value in evaluation of the abomasal function. The study was conducted on DA cattle (n=25) belonging to dairy farms in Hokkaido area, Japan. Cows were examined and sampled at days 0 (surgery), 7 and 30. Based on blood β-hydroxybutyric acid (BHBA) at day 0, DA cows were classified into three categories; DA only (<1.2 mmol/L), DA with subclinical ketosis (DA SCK: 1.2-2.4 mmol/L) and DA with clinical ketosis (DA CK: ≥2.5 mmol/L). All DA groups had higher serum gastrin than their physiological reference values in cattle both before or after surgery. Serum gastrin was significantly increased (P<0.05) in DA and DA SCK groups particularly at day 30 vs day 0. Serum pepsinogen and chlorides were not remarkably changed in any of the three diseased groups compared to reference values. Serum pepsinogen showed no significant within-and inter-group changes. The surgery and the 30-day follow-up period were not sufficient to serum gastrin to return to its physiological levels. In conclusion, further future studies may be required to investigate serum gastrin levels change in DA cattle. A longer follow up period up to 45 day is suggested.

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Value of Plasma Pepsinogen Estimation

Cited by 84 publications

References 8 publications

The serum pepsinogen level with special reference to the histology of the gastric mucosa

The serum pepsinogen level with special reference to the histology of the gastric mucosa

Genetic parameters for resistance to trichostrongylid infection in dairy sheep

Diagnostic and prognostic significance of serum gastrin and pepsinogen in dairy cows with displaced abomasum

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