Value of Plasma-Lithium Monitoring

Fry, D. E.

doi:10.1016/s0140-6736(71)92444-5

Cited by 39 publications

(7 citation statements)

References 8 publications

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“…It has been stated that prophylactic lithium is only effective when the serum lithium is maintained between 0.8 and 1.2 mmol/l (Fry & Marks, 1971). Adverse reactions are associated with serum levels over 1.5 mmol/1 and serum levels over 2.0 mmol/ may be associated with neurological symptoms and a fatal outcome (Crammer et aL, 1974).…”

Section: Discussionmentioning

confidence: 99%

Serum concentrations of lithium after three proprietary preparations of lithium carbonate (Priadel, Phasal and Camcolit).

Bennie¹,

Manzoor²,

Scott³

et al. 1977

Brit J Clinical Pharma

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1 The serum lithium concentration was measured before dosing, and at 2, 4, 6, 8, 10, 20, 22, and 24 h after three proprietary preparations of lithium carbonate (Camcolit, Phasal or Priadel). 2 A total of twenty‐ eight studies were performed on eleven patients. In seven studies the patients received Camcolit, in ten studies patients received Priadel and in eleven the patients took Phasal. 3 The dose of each preparation was adjusted during a 10 week run‐in period to maintain the serum lithium within the normal therapeutic range (0.6‐1.2 mmol/1). Five patients received one lithium preparation, one patient received three lithium preparations and five patients received four lithium preparations consecutively. 4 After a single daily dose of Phasal and Priadel, the serum lithium remained within the therapeutic range for 24 h. 5 After a single daily dose of Camcolit, the serum lithium remained within the therapeutic range for only 12 h. 6 After three doses of Camcolit (given at 0.800 h, 12.00 h, and 18.00 h) each day, the serum lithium was maintained in the therapeutic range for 24 h.

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Section: Discussionmentioning

confidence: 99%

Serum concentrations of lithium after three proprietary preparations of lithium carbonate (Priadel, Phasal and Camcolit).

Bennie¹,

Manzoor²,

Scott³

et al. 1977

Brit J Clinical Pharma

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show abstract

“…Variations on this theme would result from changes in effect being less sensitive than might be predicted to changes in concentration, as with antischizophrenic drugs, from the effect occurring only during the early stages of treatment, as with sedation to phenobarbitone, or from the effect developing more slowly than did the elevated plasma levels as might happen with almost any behavioural study. Interestingly, something approaching a model multiple dose relationship apparently occurs with lithium toxicity (Fry & Marks, 1971).…”

Section: Plasma Level Studies In Their Own Rightmentioning

confidence: 99%

Plasma level studies in psychotropic evaluation.

Curry¹

1976

Brit J Clinical Pharma

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“…Lithium treatment, therefore, lends itself to a much more accurate system for monitoring dose than any other psychotherapeutic drug (Fry and Marks, 1971). Such is not the case with lithium ion, the concentration of which can be simply, accurately and cheaply measured in almost any clinical laboratory.…”

Section: Special Properties Of Lithium As a Psychotherapeutic Drug 349mentioning

confidence: 99%

Clinical Use of Psychotherapeutic Drugs2 I

Hollister

1972

Drugs

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Value of Plasma-Lithium Monitoring

Cited by 39 publications

References 8 publications

Serum concentrations of lithium after three proprietary preparations of lithium carbonate (Priadel, Phasal and Camcolit).

Serum concentrations of lithium after three proprietary preparations of lithium carbonate (Priadel, Phasal and Camcolit).

Plasma level studies in psychotropic evaluation.

Clinical Use of Psychotherapeutic Drugs2 I

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