Value of peripheral blood ratio in diagnosis and prognosis prediction of sinonasal squamous cell carcinoma Running title: Peripheral blood ratio in SNSCC

Abstract

Sinonasal squamous cell carcinoma (SNSCC) usually presents at an advanced stage by the time of diagnosis, and there is still a lack of indicators to predict the prognosis of SNSCC patients. We aim to investigate whether the peripheral blood ratios might be good options for predicting the progress in patients with SNSCC. We performed a retrospective analysis on 198 patients with SNSCC and 63 healthy people as the normal control people (NCP) between January 2010 and December 2022. Systemic inflammatory response index (SIRI), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (LMR) were calculated. We compared the differences in these four peripheral blood ratios between the NCP and SNSCC patients and investigated the predictive value for the prognosis of SNSCC patients. SIRI, LMR, NLR, and PLR differed significantly between the NCP and SNSCC patients (P < 0.05). NLR (Area Under Curve, AUC: 0.813) had a higher diagnostic sensitivity than SIRI, LMR, and PLR for SNSCC patients. Multivariate cox-regression showed that high LMR was associated with poor prognosis. The values of NLR, SIRI, LMR, and PLR can be used as parameters for the auxiliary diagnosis and prognosis of SNSCC. In SNSCC patients, LMR is a sensitive factor in predicting OS and DMFS.