Value of oral provocation tests to aspirin and food additives in the routine investigation of asthma and chronic urticaria

Genton, Claude Yves; Frei, P. C.; Pécoud, A

doi:10.1016/0091-6749(85)90802-4

Cited by 60 publications

(42 citation statements)

References 16 publications

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“…31 Preservatives in sodas might not pose health hazards when they are consumed in minimal amounts. However, it could be postulated that when sensitive individuals consume a large amount (although an exact amount is unknown) of beverages/foods that contain food preservatives, such as sodium benzoate or sulfites, 18,19,29 they might pose health risks (eg, exacerbating or triggering asthma symptoms). In the present study, the consumption of regular soda was relatively high: about one in three students reported drinking regular soda daily, and about one in five students reported drinking regular soda at least two times per day.…”

Section: Resultsmentioning

confidence: 99%

“…[17][18][19]29,30 Most sodas contain sodium benzoate as a preservative, which has been associated with worsening of asthma symptoms. 18,19 Evidence also suggests that asthma can be worsened by drinking sodas, 15,19 and a higher risk for asthma was associated with high intake of soft drinks and sport drinks. 28 One study found that adverse reactions were observed among 26.3% of asthmatic children aged 2 to 13 years after drinking beverages containing sodium benzoate.…”

Section: Resultsmentioning

confidence: 99%

“…[14][15][16] For example, sodium benzoate is a preservative used in sodas and foods, 17 and negative reactions (eg, cough and/or wheeze) to sodium benzoate have been reported among asthmatic children and adults. 18,19 Although two studies reported that asthma symptoms were worsened by drinking sodas, 15,19 one study among New Zealand children found no association between "fizzy drinks" and ever having asthma after adjusting for lifestyle factors. 20 These inconsistent findings call for additional investigation because of the high consumption of soft drinks among US adolescents.…”

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confidence: 99%

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Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Park¹,

Blanck²,

Sherry³

et al. 2013

Journal of the Academy of Nutrition and Dietetics

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Limited research shows an inconclusive association between soda intake and asthma, potentially attributable to certain preservatives in sodas. This cross-sectional study examined the association between regular (nondiet)-soda intake and current asthma among a nationally representative sample of high school students. Analysis was based on the 2009 national Youth Risk Behavior Survey and included 15,960 students (grades 9 through 12) with data for both regular-soda intake and current asthma status. The outcome measure was current asthma (ie, told by doctor/nurse that they had asthma and still have asthma). The main exposure variable was regular-soda intake (ie, drank a can/bottle/glass of soda during the 7 days before the survey). Multivariable logistic regression was used to estimate the adjusted odds ratios for regular-soda intake with current asthma after controlling for age, sex, race/ethnicity, weight status, and current cigarette use. Overall, 10.8% of students had current asthma. In addition, 9.7% of students who did not drink regular soda had current asthma, and 14.7% of students who drank regular soda three or more times per day had current asthma. Compared with those who did not drink regular soda, odds of having current asthma were higher among students who drank regular soda two times per day (adjusted odds ratio = 1.28; 95% CI 1.02 to 1.62) and three or more times per day (adjusted odds ratio = 1.64; 95% CI 1.25 to 2.16). The association between high regular-soda intake and current asthma suggests efforts to reduce regular-soda intake among youth might have benefits beyond improving diet quality. However, this association needs additional research, such as a longitudinal examination. KeywordsSoda; Adolescents; Asthma; Youth Risk Behavior Survey (YRBS) Address correspondence to: Sohyun Park, PhD, Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop K26, 4770 Buford Highway, NE, Atlanta, GA 30341. spark3@cdc.gov. STATEMENT OF POTENTIAL CONFLICT OF INTERESTNo potential conflict of interest was reported by the authors. During the last 30 years, the prevalence of asthma has increased and is currently one of the most common chronic diseases among US children and adolescents. 6 Self-reported asthma prevalence during the preceding 12 months in 1980 was 3.5%, whereas current asthma prevalence in 2004 was 8.5% among US youth aged younger than 18 years. 7 The most current data indicate that in 2009, >10 million US youth aged 17 years and younger (14%) had ever been diagnosed with asthma, and 7.1 million children still had asthma (10%). 6 In addition, in 2007, there were 640,000 emergency department visits and 157,000 hospitalizations for asthma in US youth aged 17 years and younger. 8 In the United States, asthma-related medical expenses, including lost school and work days and early deaths, were estimated at about $56 billion in 2007. 9 Evidence suggests that, among children, males...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Park¹,

Blanck²,

Sherry³

et al. 2013

Journal of the Academy of Nutrition and Dietetics

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“…Although no published data are available on the prevalence of ASA sensitivity among patients with acute urticaria, it has been reported that one-third of patients with chronic urticaria was associated with ASA sensitivity [12]. In this study, in order to investigate the genetic mechanism involved, we studied the association between HLA genotypes in confirmed cases of ASA-induced urticaria who had cross-sensitivity to ASA and NSAIDs, and these findings were compared with those of ASA-intolerant asthma and normal controls.…”

Section: Discussionmentioning

confidence: 99%

The human leucocyte antigen‐DRB1^1302‐DQB1^0609‐DPB1^*0201 haplotype may be a strong genetic marker for aspirin‐induced urticaria

Choi

Lee

Kim

et al. 2005

Clin Experimental Allergy

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SummaryBackground Urticaria/angioedema is a common aspirin-induced allergy; however, its pathogenic mechanism is not understood. Objective In order to uncover the genetic mechanism, we studied the associations of the human leucocyte antigen (HLA) genotypes in patients with aspirin-induced urticaria compared with aspirinintolerant asthma and normal control in a Korean population. Methods Ninety-four aspirin-induced urticaria patients presenting urticaria/angioedema-induced by both ASA and NSAID (50 had underlying chronic urticaria) and showing positive responses on oral aspirin challenge test, 76 aspirin-intolerant asthmatics with positive responses on lysine-aspirin bronchoprovocation test, and 185 normal healthy controls were enrolled. HLA-DRB1, DQB1, and DPB1 genotypings were performed by direct DNA sequencing analysis. Results The allele frequencies of HLA-DRB1*1302 (18.1%) and HLA-DQB1*0609 (10.1%) in aspirin-induced urticaria were significantly higher than in aspirin-intolerant asthma (5.3%, P 5 0.0004; 2.0%, P 5 0.0024) and in normal controls (8.1%, P 5 0.0005; 3.2%, P 5 0.0008), and they remained significant after correcting for multiple comparisons. The patients with these two HLA markers had a significantly younger age than patients without, while no associations were found in with respect to atopic status, a history of previous allergic diseases, total IgE level, or presence of underlying chronic urticaria (P40.05, respectively). In haplotype analysis, the HLA-DRB1*1302-DQB1*0609-DPB1*0201 was significantly higher in the aspirin-induced urticaria (8.0%) than in the aspirin-intolerant asthma (0.7%, P 5 0.0014) and normal controls (2.0%, P 5 0.0006). Conclusion These findings suggest that the HLA-DRB1*1302-DQB1*0609-DPB1*0201 may be a strong genetic marker to determine the aspirin-induced urticaria phenotype.

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“…Sulfur dioxide and sulfites in foods have been estimated to precipitate acute asthma in 5 to 10% of asthmatics (93). Bronchoconstriction after oral administration of sulfur dioxide was seen in four of 17 adult asthmatics by Genton et al (46). Towns & Mellis (144) reported that as many as 19 of 29 children with chronic asthma reacted with bronchoconstriction when challenged with metabisulfite in a solution of 0.5% citric acid.…”

Section: Sulfitesmentioning

confidence: 99%

Hypersensitivity reactions to food additives

Hannuksela

Haahtela

1987

Allergy

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Only seldom have food additives been shown to cause true allergic (immunologicjil) reactions. Adverse effects due to various pharmacological or other mechanisms are much more common. The individual tolerance may be decreased for one reason or another, and may fluctuate from time to time. Many patients suffering from food additive reactions have atopic constitutions and such clinical symptoms as fiexural dermatitis, rhinitis and asthma. The most important skin symptoms caused by food additives are urticaria, angioneurotic edema, and contact urticaria. Azo dyes, benzoic acid and several other common food additives may aggravate or, more rarely, even cause urticaria. Spices are one of the most common causes of immunological contact urticaria. Non-immunological contact urticaria is produced by numerous spices, benzoic acid, sorbic acid, cinnamic acid, and many essential oOs. Asthma and rhinitis are the main hypersensitivity symptoms in the respiratory tract, and azo dyes, benzoic acid, and sulfitic food additives are the most common causative agents. Systemic and respiratory reactions to food colorants and benzoates have been claimed to occur more frequently in acetylsalicylic acid-(ASA-)sensitive patients than in non-reactors. Hypersensitivity reactions in organs other than the skin and respiratory tract are rare or poorly documented. Psychological factors play an essential role in both food and food additive reactions.

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Value of oral provocation tests to aspirin and food additives in the routine investigation of asthma and chronic urticaria

Cited by 60 publications

References 16 publications

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

The human leucocyte antigen‐DRB1^1302‐DQB1^0609‐DPB1^*0201 haplotype may be a strong genetic marker for aspirin‐induced urticaria

Hypersensitivity reactions to food additives

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Value of oral provocation tests to aspirin and food additives in the routine investigation of asthma and chronic urticaria

Cited by 60 publications

References 16 publications

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

The human leucocyte antigen‐DRB1*1302‐DQB1*0609‐DPB1*0201 haplotype may be a strong genetic marker for aspirin‐induced urticaria

Hypersensitivity reactions to food additives

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The human leucocyte antigen‐DRB1^1302‐DQB1^0609‐DPB1^*0201 haplotype may be a strong genetic marker for aspirin‐induced urticaria