Value of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio and red blood cell distribution width in distinguishing between reactive lymphadenopathy and lymphoma in children

Abstract

The aim of our study was to assess the diagnostic value of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW) in children with lymphadenopathy (LAP). METHODS: Between January, 2009 and December, 2018, 190 children who underwent excisional lymph node biopsy due to enlarged lymph nodes were included. The clinical and laboratory features of pediatric patients with lymph node enlargement, histopathological examination of the lymph node, and the role of complete blood count parameters in the differentiation of reactive and malignant LAP were analyzed retrospectively. RESULTS: In total, 139 (73.2 %) children had pathologically confi rmed reactive LAP and 51 (26.8 %) were diagnosed with lymphoma. Compared with the reactive LAP group, median values for NLR, MLR, PLR, and RDW were signifi cantly higher in children with lymphoma (p < 0.01). According to receiver operating characteristic curve analysis performed for distinguishing between reactive LAP and lymphomas, the area under curves of NLR, MLR, PLR, and RDW were 0.75, 0.76, 0.71, and 0.61, respectively. CONCLUSIONS: Children with histologically proven lymphoma have higher NLR, MLR, PLR, and RDW values than children with reactive LAP. NLR, MLR, PLR, and RDW tests, which can be performed even in primary health care centers, may be useful markers to determine which patients with LAP should be referred to the advanced center at an early stage for biopsy (Tab. 4, Fig. 2, Ref. 26).

Preoperative Blood Inflammatory Markers for the Differentiation of Uterine Leiomyosarcoma from Leiomyoma

“…11 However, few studies have investigated the diagnostic values of markers of systemic inflammation in different cancers (Table 5). In non-gynecologic cancers, NLR has been suggested to predict the presence of Hodgkin lymphoma, glioma, prostate cancer, or cartilaginous tumors (enchondroma and low-grade chondrosarcoma), 10,[37][38][39][40] whereas in gynecologic cancers, we have reported on the usefulness of NLR as a diagnostic marker for the presence of EOC. 8 Kim et al described the efficacy of NLR for the preoperative diagnosis of uterine sarcomas and suggested that NLR (≥2.12) might provide a more useful and costeffective means than serum CA-125 for their preoperative differentiation.…”

The Importance of Systemic Inflammatory Response Index, Systemic Immune-Inflammation Index, and Hemoglobin-Albumin-Lymphocytes-Platelets (HALP) Score in Children with Cancer

“…Recently, numerous studies have focused on the ratio of leukocytes subgroups. The inflammatory biological markers with prognostic values include NLR, PLR, and LMR (12,(20)(21)(22)(23)(24)(25)(26)(27). In our study, we found that patients' neutrophil, Iran J Pediatr.…”

“…Some of these inflammatory biomarkers are SIRI, SII index, NLR, PLR, CRP-albumin ratio, and HALP score (5-9). There is little experience with the use of these inflammatory biological markers in childhood (10)(11)(12). Herein, the aim of our study was to evaluate the importance of the biological inflammatory markers, including SII index, SIRI, and HALP score in children with cancer.…”

“…Recently, many inflammatory indices or their combination, such as systemic inflammatory response index (SIRI), systemic immune-inflammation (SII) index, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), C-reactive protein-albumin ratio, and hemoglobin-albuminlymphocyte-platelet (HALP) score have been used to predict prognosis in adults with cancer (5)(6)(7)(8)(9). Unlike adults, the studies on such biomarkers showing biological inflammatory status in children with cancer are limited (10)(11)(12). Tezol et al (12) investigated these biomarkers in children with reactive lymphadenopathy and children with lymphoma.…”

“…Unlike adults, the studies on such biomarkers showing biological inflammatory status in children with cancer are limited (10)(11)(12). Tezol et al (12) investigated these biomarkers in children with reactive lymphadenopathy and children with lymphoma. They found that NLR, LMR, PLR, and red blood cell distribution width values were significantly higher in children with lymphoma than in children with reactive lymphadenopathy.…”