Value of Neutrophil to Lymphocyte Ratio as a Predictor of Mortality in Patients Undergoing Aortic Valve Replacement

Habib, Mirette; Thawabi, Mohammad; Hawatmeh, Amer; Habib, Habib; ElKhalili, Walid; Shamoon, Fayez; Zaher, Medhat

doi:10.1016/s0735-1097(15)62042-3

Cited by 1 publication

(2 citation statements)

References 24 publications

(27 reference statements)

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“…Evidence coming from previous studies demonstrated their predictive capacity also in severe AS 6–9 . In addition, increased NLR levels were found to be linked with short‐ and long‐term mortality in patients with AS undergoing aortic valve replacement surgery 21 . Similarly, Condado et al showed that elevated NLR and PLR levels are associated with the occurrence of 30‐day adverse outcomes in patients treated with transcatheter aortic valve replacement 22 .…”

Section: Discussionmentioning

confidence: 95%

“…[6][7][8][9] In addition, increased NLR levels were found to be linked with shortand long-term mortality in patients with AS undergoing aortic valve replacement surgery. 21 Similarly, Condado et al showed that elevated NLR and PLR levels are associated with the occurrence of 30-day adverse outcomes in patients treated with transcatheter aortic valve replacement. 22 SII is a recently developed marker that brings together platelet, neutrophil, and lymphocyte counts, and reflects the balance between inflammatory and immune status.…”

Section: Discussionmentioning

confidence: 96%

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The relationship between calcific severe aortic stenosis and systemic immune‐inflammation index

et al. 2021

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Aim Calcific aortic stenosis (AS) is a common valvular disease especially in elderly population. Inflammation plays significant role in the pathophysiological mechanism. Systemic immune‐inflammation index (SII) is a novel marker of immune system and inflammation that includes neutrophil, lymphocyte, and platelet cell counts. The aim of this study was to investigate the predictive value of SII in calcific severe AS. Materials and Methods Severe calcific AS patients were categorized into two groups: High flow‐high gradient (HFHG) AS (n = 289) and low flow‐low gradient AS (n = 79). Control group included 273 patients with similar clinical and demographic characteristics but without AS. SII was calculated as absolute platelet count × absolute neutrophil count/absolute lymphocyte count. Results SII levels were 525 ± 188, 835 ± 402, and 784 ± 348 in control, HFHG AS, and LFLG AS groups, respectively (P < .001). Correlation analyses revealed significant and positive correlation between SII and mean aortic transvalvular pressure gradient (r = .342, P < .001), and negative and significant correlation between SII and AVA (r = −.461, P < .001). Multivariate analysis performed in separate models demonstrated sex, CAD, LDL, and SII levels (Odds ratio [OR]: 1.004, 95 CI%:1.003–1.004) as independent predictors of severe AS in Model 1. According to Model 2, sex, CAD, LDL, and high SII (>661) (OR:5.78, 95 CI%:3.93–4.89) remained as independent predictors of severe AS. Conclusion SII levels can be useful to predict severe calcific AS patients and significantly correlate with AVA and mean aortic transvalvular pressure gradient.

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Section: Discussionmentioning

confidence: 95%