Value of Monitoring Amylase Activities in Patients With Pancreatitis

Nordback, Isto

doi:10.1016/s0140-6736(85)92386-4

Cited by 8 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, amylases did not differ between the groups, although histology did differ. Amylase activity has been shown to be just a crude marker of injury without connection to the clinical picture of the extent of necrosis [22]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Diameter, Number and Tightness of Sutures on Pancreatic Injury Response

Lämsä¹,

Jin²,

Nordback³

et al. 2008

Dig Surg

Self Cite

View full text Add to dashboard Cite

Background: We have experimental data indicating that the pancreas is easily damaged by any intervention. The present study compared the effects of suture diameter, number of needle passes and suture tightness on rat pancreas. Methods: Under anesthesia, rat pancreas was sutured either with one loose stitch of 6-0 polydioxanone (PDS II) or 3-0 PDS II, with 5 passes of loose running 6-0 PDS II, or with 6-0 PDS II loop tightened to 0.6 or 1.2 N. Amylase activity and pancreatic tissue histology at the suturing site and farther away, were evaluated 1, 3, 7 and 21 days postoperatively. Results: Each suturing exposure and the sham-operation induced temporary amylase activity elevation on day 1 when compared with the baseline. In histology, 3-0 suture, 5 needle passes and 1.2-newton loop induced more damage than 6-0 suture, single needle pass and 0.6-newton loop, respectively. Similar but milder changes were observed in samples from the remote site. Conclusions: The pancreas reacts to suturing with widespread injury response resembling that of acute pancreatitis. In attempting to reduce suturing-induced widespread injury, as few and thin sutures and as loose suture tightness as possible should be used. Although these findings may seem obvious, they have not previously been proven in terms of histology.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Diameter, Number and Tightness of Sutures on Pancreatic Injury Response

Lämsä¹,

Jin²,

Nordback³

et al. 2008

Dig Surg

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is also worth noting that aside from the mortality rates other end‐points used were either subjective clinical findings or surrogate biochemical indices – common amongst these was the monitoring of serum (or urinary) amylase (59,61,63,65,66). This use of amylase has hence been determined as inappropriate as it reflects neither disease severity nor progress towards recovery (75,76).…”

Section: Use Of Intravenous Aprotinin In Acute Pancreatitismentioning

confidence: 99%

Aprotinin in severe acute pancreatitis

Smith

Kocher

Hunt

2010

International Journal of Clinical Practice

View full text Add to dashboard Cite

Aprotinin, a Kunitz protease inhibitor, has a wide inhibitory action with particular activity against trypsin, chymotrypsin and kallikrein, making it theoretically attractive in ameliorating the effects of acute pancreatitis. Its use in acute pancreatitis has been studied for the last 50 years with disappointing results. In this paper, we review the previous studies and argue that all the studies have not been adequately powered, have inappropriate end-points, but most importantly have not attained adequate plasma and peritoneal levels of aprotinin to produce sufficient inhibitory activity. We hypothesise that a well-powered study with adequate aprotinin dosing may clarify its clinical benefit in severe acute pancreatitis.

show abstract

“…'0"7' Experimentally, Armstrong, Taylor, and Torrance found that on injection there was no extravasation at low intraduct pressures; that, at moderate pressures, there was passage of fluid through the intercellular clefts into the periacinar spaces; and, at high pressures, duct ruptures occurred.7' With pancreatic trauma without damage to the duct system there is no rise in plasma amylase; in both clinical and experimental pancreatitis, there is little correlation between the degree of elevation of amylase and the severity of any pancreatitis; plasma amylase is elevated when the pancreatic ducts are ligated or obstructed, when substances are injected into them, or on ERCP. [72][73][74][75] On histological examination, the distinction between the two histopathological types of AP is usually clear, and HP is a separate entity from IP. Occasionally, however, the histological features may be mixed, and this, perhaps, means that an aetiological factor of HP has been added to the IP.…”

Section: Interstitial Pancreatitis: Not a Mild Form Of Haemorrhagic Pmentioning

confidence: 99%

Heretical thoughts on the pathogenesis of acute pancreatitis.

Keynes¹

1988

Gut

View full text Add to dashboard Cite

Value of Monitoring Amylase Activities in Patients With Pancreatitis

Cited by 8 publications

References 8 publications

Effects of Diameter, Number and Tightness of Sutures on Pancreatic Injury Response

Effects of Diameter, Number and Tightness of Sutures on Pancreatic Injury Response

Aprotinin in severe acute pancreatitis

Heretical thoughts on the pathogenesis of acute pancreatitis.

Contact Info

Product

Resources

About