Value of microwave ablation in treatment of large lesions of hepatocellular carcinoma

Medhat, Eman; Aziz, Ashraf Abdel; Nabeel, Mohammed; Elbaz, Tamer; Zakaria, Zeinab; Shousha, Hend Ibrahim; Amer, Ayman; Fathalah, Waleed Fouad; Maher, Rabab; Musa, Sherief

doi:10.1111/1751-2980.12259

Cited by 42 publications

(30 citation statements)

References 29 publications

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“…In the future, the usage of ablation is predicted to address the following. (A) Larger targets: as raw generator power increases, combined with higher power antennas and more array channels, MW thermal ablation is expected to make further in-roads into larger ablations that will treat 7 cm tumours or larger [121,122]. (B) Specialised antennas: designed to selectively heat focal zones presently treated with RF applicators, but in less time and with greater precision [100,101,123].…”

Section: Discussionmentioning

confidence: 99%

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Ryan¹,

Brace

2016

International Journal of Hyperthermia

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The use of microwaves (MW) for thermal cancer treatment began in the late 1970s. At first, hyperthermia was induced by using single antennas applied interstitially. This was followed by arrays of multiple interstitial antennas driven synchronously at 915 or 2450 MHz. This early work focused on hyperthermia as an adjuvant therapy, but more recently has evolved into a thermally ablative monotherapy. Increased power required to thermally ablate tissues required additional developments such as internally cooled antennas. Larger tumours have also been ablated with MW antenna arrays activated synchronously or non-synchronously. Numerical modelling has provided clinical treatment planning guidance and device design insight throughout this history. MW thermal therapy systems, treatment planning, navigation and image guidance continue to evolve to provide better tools and options for clinicians and patients in order to provide targeting optimisation with the goal of improved treatment for the patient and durable cancer eradication. This paper reviews the history and related technological developments, including antenna design, of MW heating for both hyperthermia and ablation.

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Section: Discussionmentioning

confidence: 99%

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Ryan¹,

Brace

2016

International Journal of Hyperthermia

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“…Local tumor progression was 19.2 % and distant tumor progression within the liver was 23.1 % with a mean survival of 21.5 months. No major complications or deaths related to the procedure were recorded [46].…”

Section: Mwa Results In Hccmentioning

confidence: 99%

Microwave Ablation (MWA): Basics, Technique and Results in Primary and Metastatic Liver Neoplasms – Review Article

Vogl

Nour-Eldin

Hammerstingl

et al. 2017

Fortschr Röntgenstr

129

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ZUSAMMENFASSUNGHintergrund Der lokoregionale interventionelle onkologische Behandlungsansatz ist eine anerkannte Behandlungsoption bei Lebermalignomen, insbesondere beim hepatozellulären Karzinom (HCC) und oligonodulären Lebermetastasen. Material und Methode ABSTR AC T PurposeThe locoregional interventional oncological treatment approach is an accepted modality for liver neoplasms, especially for hepatocellular carcinoma (HCC) and oligonodular liver metastases. Materials and MethodsThe main aim of ablation therapies like microwave ablation (MWA) is to eradicate all malignant cells in a minimally invasive technique under imaging guidance while preserving the healthy tissue with a sufficient safety margin (at least 5 mm) surrounding the ablated lesion.Results Ablation therapy can be performed via a percutaneous, laparoscopic or intraoperative approach under ultrasound, MRI or CT guidance for adequate localization and monitoring of the ablation process.Conclusion Ablation is the method of choice for oligonodular HCCs ≤ 3 cm. The technical success rate varies from 88 % to This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.98 % and progression-free survival (PFS) at 3 years from 27 % to 91.7 %. The same criteria apply to the therapy of liver metastases. Key Points▪ Careful selection of patients proves to be essential for optimum results of MWA ▪ Interventionists should be familiar with all aspects of complication and rapid assessment of imaging methods in order to evaluate induced damage by thermal ablation ▪ MWA seems to have some advantages over radiofrequency ablation, like shorter ablation time, less pain, less heat sink effect; however, scientific proof is needed

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“…However, these treatments have not produced satisfactory efficacy for larger tumors because of limited heat conduction, severe impairment of liver function and adjacent vital organs. It is difficult to achieve complete eradication of large tumors by relying solely on thermal ablative techniques [14,22]. In order to solve the above problems, a new strategy of 3D visualization assist with US-PMWA following TACE was adopted for treatment of 14 patients with large HCC in this study.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided percutaneous microwave ablation assisted by athree-dimensional visualization treatment platform combined with transcatheter arterial chemoembolization for a single large hepatocellular carcinoma 5 cm or larger: a preliminary clinical application

Ren

Liang

et al. 2018

International Journal of Hyperthermia

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Value of microwave ablation in treatment of large lesions of hepatocellular carcinoma

Abstract: Percutaneous microwave ablation is safe and effective in the treatment of large HCC tumors. Patients' survival and local tumor control were acceptable.

Cited by 42 publications

References 29 publications

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Microwave Ablation (MWA): Basics, Technique and Results in Primary and Metastatic Liver Neoplasms – Review Article

Ultrasound-guided percutaneous microwave ablation assisted by athree-dimensional visualization treatment platform combined with transcatheter arterial chemoembolization for a single large hepatocellular carcinoma 5 cm or larger: a preliminary clinical application

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