Value of microbiology study in congenital nasolacrimal duct obstruction

Al-Faky, Yasser H; Naeem, Tahir; Al-Sobaie, Nora; Al-Huthail, Reem; Al-Odan, Hessa; Osman, Essam; Mousa, Ahmad A.

doi:10.1016/j.sjopt.2012.03.001

Cited by 9 publications

(13 citation statements)

References 18 publications

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“…There have been a few studies investigating the microbiology in CNLDO, and the bacterial spectrum varies among different age groups and changes over time (Table 3) [8][9][10][11][13][14][15][16][17][18]. Most of the previous literatures included both infants and young children.…”

Section: Discussionmentioning

confidence: 99%

Lacrimal Sac Bacteriology and Susceptibility Pattern in Infants with Congenital Nasolacrimal Duct Obstruction in the 1st Year of Life: A Cross-Sectional Study

Zheng

Choy

Zhou

et al. 2020

Preprint

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Background: Congenital nasolacrimal duct obstruction (CNLDO) is one of the main causes of epiphora in infants, and antibiotics are usually used as a conservative therapy in the first year. Yet, little is known about the bacteriology of the occluded lacrimal drainage system in this group of patients. The aim of this study was to evaluate the microbiology of lacrimal sac (LS) in Chinese children with CNLDO in their first year of life.Methods: Patients with CNLDO between May 1, 2017 and August 31, 2018 at a tertiary care children’s hospital were enrolled. The study recruited infants who received lacrimal probing under 1 year old, and refluxed discharge from LS was collected. Samples were cultured and susceptibility test was performed for positive culture.Results: Thirty-two patients with CNLDO were included. The ratio of male to female was 23:9. The mean age was 6.7 ± 2.4 (1.7-12) months. Positive cultures was identified in 87.5% of the sample, and presented 38 strains of bacteria. Mixed infection was identified in 10 (31.3%) children. Gram-positive bacteria accounted for 60.5% of all the strains, with Streptococcus (50%) being the most frequent species, whereas Haemophilus (21.1%) and Neisseriae (13.2%) were most common isolates for Gram-negative organisms. Methicillin-resistant Staphylococcus aureus (MRSA) was detected in 2 infants whose symptoms resolved by a routine probing. No difference of bacteriology pattern was detected between patients under 6 months old and those beyond. The pathogens were highly sensitive to chloramphenicol (88%) and levofloxacin (84%), but resistant to erythromycin (40%) and sulfamethoxazole (32%).Conclusions: Infants with CNLDO under 1 year of age presented predominance of Streptococcus as Gram-positive organism, and Haemophilus as Gram-negative organism. Levofloxacin was an active topical antibiotic agent with few chance of resistance especially for Chinese children. These findings could help clinicians choose optimal medicine for CNLDO as the conservative treatments.

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Section: Discussionmentioning

confidence: 99%

Lacrimal Sac Bacteriology and Susceptibility Pattern in Infants with Congenital Nasolacrimal Duct Obstruction in the 1st Year of Life: A Cross-Sectional Study

Zheng

Choy

Zhou

et al. 2020

Preprint

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“…The results are very similar to those reported by Bareja and Ghose and Al-Faky et al . [1415] Brook and Frazier who studied the bacteriological profile of the dacryocystitis patients in the age group 14–81 years, reported S. aureus followed by S. epidermidis as the common causative organisms. [16] The inclusion of causes other than congenital NLDO did not alter our results much from the results of those studies that solely studied the bacteriology of congenital cases of NLDO.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile of the patients with pediatric epiphora in a tertiary eye care center

Dhiman

Chawla

Chandra

et al. 2017

Indian J Ophthalmol

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Purpose:To study the clinical profile of children aged <10 years presenting with epiphora at a tertiary eye care center, to compare the clinical profile between the early onset (<3 years) and the late-onset (≥3 years) group, and to study the success of different treatment modalities.Materials and Methods:A prospective nonrandomized observational study was conducted in 209 eyes of 167 patients (42 bilateral cases). The main outcome measure was postoperative relief of presenting symptoms and signs at 3 months follow-up.Results:Fifty-five percent cases (92 of 167) were early-onset cases, and 45% (75 of 167) were late onset. The male:female ratio was 1.9:1. Seventy-five percent cases were unilateral. The etiological profile was –76% cases of congenital nasolacrimal duct obstruction (NLDO), 18% traumatic/surgical, 4% acquired NLDO, and 2% punctal causes. The overall success rate of all the treatment modalities in our study was 80% (167/208) –82% for sac massage, 77% for probing, 79% for intubation dacryocystorhinostomy, and 100% for punctal surgery. A significant association was noted between the treatment outcome and laterality (P = 0.04), presence of infection (P = 0.032), symptom severity (P = 0.027), history of previous treatment (P = 0.024), and age. No significant association was found between the treatment outcome and gender (P = 0.73), socioeconomic status (P = 0.43), etiology (P = 0.45), and treatment modality (P = 0.33).Conclusion:This study describes the complete range of causes and treatment modalities for pediatric epiphora and highlights the etiology, signs and symptoms, treatment, and the comparative outcome between the early versus the late-onset group and analyses the factors predictive of the outcome.

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“…Literatürde benzer şekilde izole edilen etkenlerin sıklıkla gram-pozitif olduğunu bildiren çok sayıda çalışma mevcuttur. [13][14][15][16][17][18][19][20][21] Bu çalışmaların sonuçları Tablo 2'de özetlenmiştir. Gram-pozitif mikroorganizmalardan S. pneumoniae ve S. aureus; %29.6 ve %11.1 oranları ile en sık izole edilen mikroorganizmalardı.…”

Section: Discussionunclassified

“…[18] Kuchar, Usha ve Al-Faky, çalışmalarında en sık izole edilen iki bakteriyi bizim sonuçlarımızdan farklı olarak Streptococcus pneumoniae ve Haemophilus influenzae olarak bildirmiş-lerdir. [13,19,20] İzole edilen gram-negatif mikroorganizmaların oranı çalışmamızda %14.8 idi. Bu oran Bareja ve Ghose ile Göncü ve ark.nın çalışmalarında bildirdikleri oranlara benzemektedir (sırasıyla %14.3 ve %16.6).…”

Section: Discussionunclassified

“…[16,18] Birçok çalışmada gram-pozitif mikroorganizmaların sıklıkla etken olduğu bildirilse de, gram-negatif mikroorganizmaların daha sık görüldüğünü bildiren çalışmalar da mevcuttur. [19][20][21] Doğuştan nazolakrimal kanal tıkanıklığı zemininde gelişen enfeksiyon durumunda uygun tedavi için bölgede sık görülen mikroorganizmalar ve antibiyotik duyarlılıkları gözönüne alınmalıdır. Ülkemizde daha önce yapılan iki çalışmada nazolakrimal kanal tıkanıklığında enfeksiyona en sık sebep olan mikroorganizmaların gram-pozitif ajanlar olup, bunlardan Streptococcus pneumoniae'nın en sık görülen gram pozitif etken olduğu bildirilmiştir.…”

Section: Discussionunclassified

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Microorganisms and antibiotic sensitivity in infection of congenital nasolacrimal duct obstruction

Cevher¹,

Şahinoğlu-Keşkek²,

Kayiklik³

et al. 2014

J Kartal TR

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Value of microbiology study in congenital nasolacrimal duct obstruction

Abstract: Microbiology study can predict tight CNLDO and helps in choosing the most successful treatment option. CNLDO with Staphylococcus infection and Serratia marcescens were likely to have tight NLD obstruction and silastic intubation had better outcomes.

Cited by 9 publications

References 18 publications

Lacrimal Sac Bacteriology and Susceptibility Pattern in Infants with Congenital Nasolacrimal Duct Obstruction in the 1st Year of Life: A Cross-Sectional Study

Lacrimal Sac Bacteriology and Susceptibility Pattern in Infants with Congenital Nasolacrimal Duct Obstruction in the 1st Year of Life: A Cross-Sectional Study

Clinical profile of the patients with pediatric epiphora in a tertiary eye care center

Microorganisms and antibiotic sensitivity in infection of congenital nasolacrimal duct obstruction

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