Value of magnetic resonance imaging in evaluating the pancreatic allograft transplant complications

Liu, Yubao; Akisik, Fatih; Tirkes, Temel; Tann, Mark; Jennings, S. Gregory; Lin, Chen; Kakarala, Bharat; Fridell, Jonathan A.; Powelson, John A.; Liang, Changhong

doi:10.1007/s00261-015-0408-x

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…As an example, Doppler imaging of the mitral annulus can be a sensitive, but not specific technique for detecting severe heart transplant rejection . Newer MRI technologies that allow for diffusion weighted imaging can noninvasively evaluate tissue viability and acute kidney transplant rejection and postpancreatic transplant complications . The utility of these in VCA and cutaneous evaluation, however, may be more tenuous.…”

Section: Strengths and Limitations Of The 2007 Banff Vca Working Clasmentioning

confidence: 99%

Vascularized composite allotransplantation: a closer look at the banff working classification

et al. 2016

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SUMMARYThe first Banff vascularized composite allotransplantation meeting was held in 2007 to standardize criteria for the characterization and reporting of severity and types of rejection. As a result, the 2007 Banff VCA working classification for skin allograft pathology was formalized and now serves as the standard for diagnosis of VCA rejection. Similar to other working classification systems, strengths and limitations have been identified including the adequacy of the specimen, the definition of severity between grades, the reproducibility, the adequacy of the specimens, the types of rejection, and the integration of newer technologies such as molecular and genomic approaches. Although a relatively few number of cases have been performed and followed up to date, additional phenotypes such as antibodymediated rejection, fibrosis, atrophy, and vascular changes are being reported and characterized based on accumulated experience in the field of VCA and parallels with other solid organs. This study aims to consider strengths and limitations of the Banff VCA working system and highlights ongoing challenges and opportunities available related to histopathology in this emerging field of transplantation.

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Section: Strengths and Limitations Of The 2007 Banff Vca Working Clasmentioning

confidence: 99%

Vascularized composite allotransplantation: a closer look at the banff working classification

et al. 2016

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“…Autologous grafts are considered as the gold standard, but they often include donor site morbidity where healthy tissue is removed from one site of the body to replace injured or missing tissue [ 17 ] and have limitations depending on the graft area size. Allogeneic grafts eliminate the donor site morbidity but may induce an immune response in the recipient [ 18 ], rejection with subsequent necrosis [ 19 ], and allograft removal or replacement.…”

Section: Introductionmentioning

confidence: 99%

Soft Tissue Repair with Easy-Accessible Autologous Newborn Placenta or Umbilical Cord Blood in Severe Malformations: A Primary Evaluation

Ekblad

Fossum

Götherström

2017

Stem Cells International

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Disrupted organogenesis leads to permanent malformations that may require surgical correction. Autologous tissue grafts may be needed in severe lack of orthotopic tissue but include donor site morbidity. The placenta is commonly discarded after birth and has a therapeutic potential. The aim of this study was to determine if the amnion from placenta or plasma rich of growth factors (PRGF) with mononuclear cells (MNC) from umbilical cord blood (UCB), collected noninvasively, could be used as bio-constructs for autologous transplantation as an easy-accessible no cell culture-required method. Human amnion and PRGF gel were isolated and kept in culture for up to 21 days with or without small intestine submucosa (SIS). The cells in the constructs showed a robust phenotype without induced increased proliferation (Ki67) or apoptosis (caspase 3), but the constructs showed decreased integrity of the amnion-epithelial layer at the end of culture. Amnion-residing cells in the SIS constructs expressed CD73 or pan-cytokeratin, and cells in the PRGF-SIS constructs expressed CD45 and CD34. This study shows that amnion and UCB are potential sources for production of autologous grafts in the correction of congenital soft tissue defects. The constructs can be made promptly after birth with minimal handling or cell expansion needed.

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Pancreas Transplantation

Tirkes¹

2018

Transplantation Imaging

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Value of magnetic resonance imaging in evaluating the pancreatic allograft transplant complications

Abstract: Contrast-enhanced MRI is useful for the non-invasive assessment of pancreas transplant complications.

Cited by 6 publications

References 28 publications

Vascularized composite allotransplantation: a closer look at the banff working classification

Vascularized composite allotransplantation: a closer look at the banff working classification

Soft Tissue Repair with Easy-Accessible Autologous Newborn Placenta or Umbilical Cord Blood in Severe Malformations: A Primary Evaluation

Pancreas Transplantation

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