Value of differential diagnosis of contrast‑enhanced ultrasound in benign and malignant thyroid nodules with microcalcification

Gao, Zhixiang; Lu, Qin; Yan, Jiping

doi:10.3892/ol.2019.10107

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Bolus injection doses in adults are also higher when evaluating these small organs in comparison to those used for the adult liver. When examining the adult thyroid, CEUS doses of 1.0-4.8 mL per bolus injection of SonoVue have been used [7][8][9][10][11][12][13]. Lymph node CEUS has been performed with bolus injections ranging from 1.5 to 4.8 mL [14][15][16].…”

Section: Ultrasound Contrast Agent Dosementioning

confidence: 99%

Contrast-enhanced ultrasound of the small organs in children

et al. 2021

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In pediatric and adult populations, intravenous contrast-enhanced ultrasound (CEUS) remains off-label for imaging of organs other than the liver and heart. This limited scope inhibits potential benefits of the new modality from a more widespread utilization. Yet, CEUS is potentially useful for imaging small organs such as the thyroid gland, lymph nodes, testes, ovaries and uterus, with all having locations and vasculature favorable for this type of examination. In the adult population, the utility of CEUS has been demonstrated in a growing number of studies for the evaluation of these small organs. The aim of this article is to present a review of pediatric CEUS of the thyroid gland, lymph nodes, testes, ovaries and uterus as well as to draw from the adult literature indications for possible applications in children.

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Section: Ultrasound Contrast Agent Dosementioning

confidence: 99%

Contrast-enhanced ultrasound of the small organs in children

et al. 2021

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“…This technique not only enhances image resolution but also broadens the scope and depth of ultrasound applications. 5,6 However, traditional ultrasound contrast agents, typically in the micron size range, have limitations such as short circulation times and difficulties in extravascular visualization due to their larger size. These agents are primarily suitable for vascular imaging rather than tumor visualization.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Hematoporphyrin-Poly(Lactic Acid) Nanoparticles Encapsulated Perfluoropentane/Salicylic Acid for Enhanced US/CEST MR Bimodal Imaging

Ding,

Xu,

Luo

et al. 2024

IJN

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Medical imaging modalities, such as magnetic resonance imaging (MRI), ultrasound, and fluorescence imaging, have gained widespread acceptance in clinical practice for tumor diagnosis. Each imaging modality has its own unique principles, advantages, and limitations, thus necessitating a multimodal approach for a comprehensive disease understanding of the disease process. To enhance diagnostic precision, physicians frequently integrate data from multiple imaging modalities, driving research advancements in multimodal imaging technology research. Methods: In this study, hematoporphyrin-poly (lactic acid) (HP-PLLA) polymer was prepared via ring-opening polymerization and thoroughly characterized using FT-IR, 1 H-NMR, XRD, and TGA. HP-PLLA based nanoparticles encapsulating perfluoropentane (PFP) and salicylic acid were prepared via emulsion-solvent evaporation. Zeta potential and mean diameter were assessed using DLS and TEM. Biocompatibility was evaluated via cell migration, hemolysis, and cytotoxicity assays. Ultrasonic imaging was performed with a dedicated apparatus, while CEST MRI was conducted using a 7.0 T animal scanner. Results: We designed and prepared a novel dual-mode nanoimaging probe SA/PFP@HP-PLLA NPs. PFP enhanced US imaging, while salicylic acid bolstered CEST imaging. With an average size of 74.43 ± 1.12 nm, a polydispersity index of 0.175 ± 0.015, and a surface zeta potential of −64.1 ± 2.11 mV. These NPs exhibit excellent biocompatibility and stability. Both in vitro and in vivo experiments confirmed the SA

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Efficacy and safety of radiofrequency ablation for calcified benign thyroid nodules: results of over 5 years' follow-up

et al. 2022

BMC Med Imaging

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Purpose To evaluate the efficacy and safety of radiofrequency ablation (RFA) for treating calcified benign thyroid nodules (CBTNs). Methods Fifty-two patients with 52 CBTNs who underwent RFA in our hospital were included in this retrospective study. According to the size of calcifications, CBTNs were divided into two groups: the punctate echogenic foci (PEF) group and macrocalcification group. Moreover, the macrocalcification group was further subdivided into two groups, the strong group and the weak group, based on their morphologic characteristics. After the RFA procedure, routine ultrasound (US) and clinical evaluation were performed at 1, 3, 6 and 12 months postoperatively and every 12 months thereafter. Results The mean follow-up time was 68.98 ± 7.68 months (60–87 months), and the 5-year mean volume reduction rate (VRR) after RFA was 92.95%, with a complication rate of 0.6% (3/52). The mean initial volume of the macrocalcification group was significantly larger than that of the PEF group (9.94 ± 24.60 ml vs. 0.23 ± 0.22 ml, respectively; P = 0.011). Thus, their VRRs were not comparable between the two groups. However, baseline characteristics did not show statistically significant differences between the strong and weak macrocalcification subgroups. The VRRs of the strong subgroup were significantly lower than those of the weak subgroup at the 3-year, 4-year, and 5-year follow-ups. Conclusion RFA was effective and safe for treating CBTNs. Strong macrocalcification was related to the VRR of CBTNs after the RFA procedure.

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Value of differential diagnosis of contrast‑enhanced ultrasound in benign and malignant thyroid nodules with microcalcification

Cited by 4 publications

References 15 publications

Contrast-enhanced ultrasound of the small organs in children

Contrast-enhanced ultrasound of the small organs in children

Preparation of Hematoporphyrin-Poly(Lactic Acid) Nanoparticles Encapsulated Perfluoropentane/Salicylic Acid for Enhanced US/CEST MR Bimodal Imaging

Efficacy and safety of radiofrequency ablation for calcified benign thyroid nodules: results of over 5 years' follow-up

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