Value of CT-guided core-needle biopsy in diagnosis and classification of malignant lymphomas using automated biopsy gun

Abstract

AIM:To evaluate the value of CT-guided core-needle biopsy in diagnosis and classification of malignant lymphomas.

Diagnostic precision of image-guided multisampling core needle biopsy of suspected lymphomas in a primary care hospital

“…It is important to note that the lack of precise subtyping/grading in a minority of cases did not preclude a therapeutic decision to be made for 62/63 patients (98%) with lymphoma. These rates not only compare favourably with those obtained in more homogeneous patient populations (de Kerviler et al, 2000(de Kerviler et al, , 2007Demharter et al, 2001;Screaton et al, 2002;Balestreri et al, 2005;Li et al, 2005;Sklair-Levy et al, 2005;de Larrinoa et al, 2007;Lachar et al, 2007) but also with results usually obtained by complete lymph node analysis. On the other hand, the diagnostic yield of CNB for diagnosis of benignity was only 53%, confirming that a definitive diagnosis for a benign disorder is a difficult task.…”

“…However, the validity of CNB for lymphoma diagnosis is still controversial, and entire lymph node removal is often proposed as the best procedure Engert and Dreyling, 2008;Tilly and Dreyling, 2008). Moreover, most of the studies (de Kerviler et al, 2000;Demharter et al, 2001;Screaton et al, 2002;Balestreri et al, 2005;Li et al, 2005;Sklair-Levy et al, 2005;de Kerviler et al, 2007;de Larrinoa et al, 2007;Lachar et al, 2007) include patients with a high probability of lymphoma diagnosis assessed in reference centres for lymphoproliferative diseases. This study was designed to determine whether CNB can also be recommended in the context of a primary care hospital where a large range of malignant and benign diagnoses can be expected.…”

“…Thus, image-guided Diagnostic precision of multisampling CNB P Loubeyre et al large-cutting CNB has been proposed as the initial procedure for the diagnosis of deep-seated lymphomas (de Kerviler et al, 2000;Demharter et al, 2001;Balestreri et al, 2005;Li et al, 2005;SklairLevy et al, 2005;Lachar et al, 2007;de Larrinoa et al, 2007), and in some institutions for suspect peripheral lymph nodes (Screaton et al, 2002;de Kerviler et al, 2007). Although variable endpoints were analysed in those studies with highly diverse designs, CNB appears to be a valuable approach with sensitivity for diagnosing lymphoma at 87 -89% (Demharter et al, 2001;Balestreri et al, 2005), overall diagnostic yield at 84% , unequivocal diagnosis of lymphoma at 91% (Lachar et al, 2007), overall diagnostic accuracy for lymphoma typing at 88% (de Larrinoa et al, 2007), sufficient information such that a therapeutic decision could be made at 96% (de Kerviler et al, 2007) and diagnosis of lymphoma with subtyping ranging from 76 to 85% (de Kerviler et al, 2000;Li et al, 2005). However, the validity of CNB for lymphoma diagnosis is still controversial, and entire lymph node removal is often proposed as the best procedure Engert and Dreyling, 2008;Tilly and Dreyling, 2008).…”

“…However, the excisional biopsy of enlarged lymph nodes is still advocated as the gold standard in the diagnostic evaluation of lymphoma Engert and Dreyling, 2008;Tilly and Dreyling, 2008). Nonetheless, in several centres, percutaneous image-guided CNB, which is a minimally invasive procedure, is used as an alternative to excisional biopsy for diagnosing lymphomas (de Kerviler et al, 2000;Demharter et al, 2001;Screaton et al, 2002;Balestreri et al, 2005;Li et al, 2005;Sklair-Levy et al, 2005;Lachar et al, 2007;de Kerviler et al, 2007;de Larrinoa et al, 2007). This is particularly true if suspected nodes or masses are deep seated or if the clinical condition of patients is severely impaired.…”

Thoracoscopic coaxial cutting needle biopsy for clinically suspected lung cancer: technical details, diagnostic accuracy, and probable complications

“…This disposable, coaxial cutting needle has 16 gauge outer cannula and inner, notched rod in which a tissue specimen is cut, trapped, and withdrawn. The needle is commonly used for percutaneous biopsy of lymph nodes [5], liver [6], kidney [7], etc. One to two passes were made to obtain adequate amount of samples.…”