Value of contrast-enhanced ultrasound in rheumatoid arthritis

Zordo, Tobias De; Mlekusch, Sabine; Feuchtner, Gudrun; Mur, Erich; Schirmer, Michael; Klauser, Andrea

doi:10.1016/j.ejrad.2007.07.011

Cited by 55 publications

(26 citation statements)

References 55 publications

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“…With arthroscopy as a reference a study has proved reliability of contrast-enhanced US in the detection of synovial vascularity [Fiocco et al 2003]. US contrast media can help in early detection and follow up of disease activity in RA [De Zordo et al 2007]. However, the routine use of contrast agents for MSK US examinations is not established enough as it is for MRI.…”

Section: Contrast-enhanced Usmentioning

confidence: 99%

Role of diagnostic ultrasound in the assessment of musculoskeletal diseases

Patil

Dasgupta

2012

Therapeutic Advances in Musculoskeletal

121

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Abstract:The wide availability and recent improvement in technology coupled with portability, low cost and safety makes ultrasound the first choice imaging investigation for the evaluation of musculoskeletal diseases. Diagnostic use of ultrasound findings is greatly enhanced by knowledge of the clinical presentation. Conversely, ultrasound skills with its prerequisite anatomical knowledge make the clinical diagnosis more precise and reduce uncertainty in the choice of therapy. Therefore, it is essential for rheumatologists to acquire ultrasonography skills in order to improve patient care. Ultrasound examination provides an excellent opportunity for patient education and to explain the rationale for therapy. This review summarizes the indications for musculoskeletal ultrasound and describes its role in diagnosis, monitoring and prognosis.

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Section: Contrast-enhanced Usmentioning

confidence: 99%

Role of diagnostic ultrasound in the assessment of musculoskeletal diseases

Patil

Dasgupta

2012

Therapeutic Advances in Musculoskeletal

121

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“…The contrastenhanced ultrasound is a new technology capable of enhancing tissues containing microvessels. The synovitis with hemangiectasis and more microvessel angiogenesis able to be enhanced under the contrast-enhanced ultrasound [15,16]. In the past, the high-resolution ultrasound and contrast-enhanced ultrasound have been applied to determine and observe the disease situation and therapeutic effect for RA.…”

Section: Discussionmentioning

confidence: 99%

Antigen-induced arthritis in rabbits: a comparative study between high-resolution ultrasound and contrast-enhanced ultrasound and pathologic findings

et al. 2011

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The objective of this study was to explore the feasibility and value of high-resolution ultrasound and contrast-enhanced ultrasound in evaluation of synovitis in rabbit knee joint in antigen-induced arthritis (AIA). Thirty-six rabbits were divided into three groups, each injected with different doses of ovalbumin (OVA) into the right knee joint. On week 1 and 4, 6 randomly selected in each group were killed. Each knee joint undergone the high-resolution ultrasound to measure capsule thickness and contrast-enhanced ultrasound to measure synovium thickness. The results from the ultrasound examinations were compared with those of pathologic examinations. Different OVA doses resulted in different modeling success rate, different pathological synovitis score, and different capsule and synovium thickness measured by ultrasound. The diagnostic accuracy of synovitis by ultrasound was high. The ultrasound measurement revealed that the capsule thickness on week 4 was lessened than that on week 1, while the synovial thickness on week 4 was greater than that on week 1. Both the joint capsule and synovium thickness measured by ultrasound were significantly and positively correlated to the pathologic synovitis score (P < 0.05). The synovial thickness on week 4 is more correlated to the synovitis score than the capsule thickness, rather than that on week 1. Injection of OVA of different doses results in different modeling success rate and synovitis severity. The high-resolution ultrasound and contrast-enhanced ultrasound can be used to determine whether the AIA was made successfully and evaluate the synovitis severity. In chronic inflammatory phase, the contrast-enhanced ultrasound has better effect.

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“…Moreover, Weidekamm et al [23] demonstrated that the decrease of AUC was observed also in cases with persistent PD. Due to the increased sensitivity of CEUS in detecting slow flow and flow in small vessels compared with PD [14,17,37], it is possible that TIC parameters detect the minimal changes in the synovial vascularisation and correlate less with PD [23].…”

Section: Discussionmentioning

confidence: 99%

“…Contrast enhanced ultrasonography (CEUS) allows a better visualization of blood flow in small vessels with low velocity, providing more information on synovial inflammation comparing to PDUS [13][14][15][16][17]. Objective CEUS measurements using time-intensity curves (TIC) parameters calculated by dedicated software may provide information about the disease activity in RA [18].…”

Section: Introductionmentioning

confidence: 99%

The evolution of time-intensity curves of contrast enhanced ultrasonography in early arthritis patients with wrist involvement.

Tămaș

Bondor

Rednic³

et al. 2015

Med Ultrason

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Aims: The aim of the study was to assess the evolution of time-intensity curves parameters of contrast-enhanced ultrasonography (CEUS) after 6 months of conventional treatment in early arthritis patients with wrist involvement. Material and methods: Patients diagnosed with early rheumatoid arthritis or undifferentiated arthritis on the basis of 2010 ACR/EU-LAR classification criteria, with bilateral wrist arthritis and both radiocarpal (RC) and intercarpal (IC) synovial hypertrophy identified by grey-scale ultrasonography, were enrolled. Synovial hypertrophy was semi-quantitatively scored (grade 0-3) by grey-scale and by Power Doppler at wrist level. CEUS was performed using Sonovue. The region of interest was selected as the area corresponding to the synovial hypertrophy of the RC and IC joints. Time-intensity curves parameters were calculated with Contrast Dynamic Software. The minimum and the maximum values of Peak, area under the curve (AUC), and slope were selected for each patient at baseline and after 6 months of conventional treatment. The difference between the visits was noted as "Δ". Results: Eleven patients fulfilled the inclusion criteria. Maximum time-intensity curves parameters' difference significantly decreased at 6 months: Peak (30.00±5.90% vs 23.22±5.22%, p=0.008), AUC (1206.08±216.91%s vs 949.13±280.12%s, p=0.04) and slope (1.6 (1.4;2.3) %/s vs 1(0.7;1.2) %/s, p=0.03). Moderate correlations were found between maximum ΔPeak, maximum ΔAUC and maximum ΔPower Doppler grade (r=0.44, p=0.17; r=0.46, p=0.16, respectively). Conclusions: Peak and AUC for joints that had high baseline values significantly decreased following treatment with conventional synthetic drugs in EA patients with wrist arthritis. This decrease in Peak and AUC was moderately correlated with a decrease in US parameters. The joint with the highest values of these parameters may be used for evaluation of EA patients at follow-up.

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Value of contrast-enhanced ultrasound in rheumatoid arthritis

Cited by 55 publications

References 55 publications

Role of diagnostic ultrasound in the assessment of musculoskeletal diseases

Role of diagnostic ultrasound in the assessment of musculoskeletal diseases

Antigen-induced arthritis in rabbits: a comparative study between high-resolution ultrasound and contrast-enhanced ultrasound and pathologic findings

The evolution of time-intensity curves of contrast enhanced ultrasonography in early arthritis patients with wrist involvement.

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