Value of Contrast‐Enhanced Ultrasound in the Diagnosis of Renal Cancer and in Comparison With Contrast‐Enhanced Computed Tomography: A Meta‐analysis

Abstract

Contrast-enhanced US has high sensitivity and moderate specificity in the differential diagnosis of renal cancer. The diagnostic sensitivity of CEUS in renal cancer was higher than that of CECT, suggesting that CEUS could be used as a preferred diagnostic tool for renal cancer.

Comparison of the Diagnostic Performance of Contrast-enhanced Ultrasound with That of Contrast-enhanced Computed Tomography and Contrast-enhanced Magnetic Resonance Imaging in the Evaluation of Renal Masses: A Systematic Review and Meta-analysis

“…To the best of our knowledge, there already exist three other SRs assessing QDP of CEUS versus that of CECT or CEMR in the evaluation of benign and malignant RMs [33][34][35]. However, our SR stands out from those in several points.…”

“…Secondly, compared with those reviews, we additionally performed subgroup analyses for specific characteristics of RMs, for example, cystic or solid patterns (see Table 2). Thirdly, although our study contains results about a balanced distribution of cystic and solid RMs, the studies of Lan et al [35] as well as Zhou et al [34] included only CRMs, and the study of Zhang et al [33] almost exclusively included solid RMs. Fourthly, our overall analysis has been performed for FD by pathology on the one hand and for reaffirmed diagnosis by follow-up imaging on the other hand for all three modalities.…”

“…However, regarding the available literature, this remains a matter of debate. Zhang et al [33] reported higher sensitivity and specificity for CEUS versus CECT (0.94 vs 0.85 and 0.77 vs 0.75, respectively). Lan et al [35] showed higher sensitivity but lower specificity of CEUS compared with CECT (0.95 vs 0.90 and 0.79 vs 0.85, respectively).…”

“…Fourthly, our overall analysis has been performed for FD by pathology on the one hand and for reaffirmed diagnosis by follow-up imaging on the other hand for all three modalities. Zhou et al [34] performed this analysis only for CEUS versus CEMR, Zhang et al [33] performed it only for CEUS, and Lan et al [35] performed no separate analysis. The currently available evidence suggests that both CECT and CEMR are considered to be the gold standard in the characterisation of solid RMs and CRMs [1,25,36,37].…”

Effectiveness of contrast-enhanced ultrasound for detecting the staging and grading of bladder cancer: a systematic review and meta-analysis

“…method for postoperative follow-up and can provide effective imaging information. Unlike other previous studies [28][29][30][31], our study mainly analysed the accuracy of CEUS in the diagnosis of BC invasion degree by taking histology as the reference standard.…”