Value of Combining Optical Coherence Tomography with Fundus Photography in Screening Retinopathy in Patients with High Myopia

Abstract

Objective. To explore the value of combining optical coherence tomography (OCT) with fundus photography in screening retinopathy in patients with high myopia. Methods. By means of retrospective study, 40 high myopia patients with retinopathy treated in our hospital from January 2020 to January 2021 were selected as the study group, and 40 healthy individuals in the same period were included in the control group. All patients received traditional ophthalmic examination, and accepted fundus fluorescence imaging, OCT, and fundus photography examination step by step by the same operator. After that, three physicians read the slides by the double blind method, and took the results of fundus fluorescence imaging as the gold standard to analyze the diagnostic efficacy of OCT, fundus photography and their combination. Results. The clinical data and examination results showed that no statistical differences in general data including patients’ mean age, gender ratio, and educational degree between the study group and the control group were observed (P > 0.05), and the nerve thickness above/below the optic disk and temporal/nasal nerve thickness of the optic disk of the study group were significantly different from those of the control group (P < 0.001); the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy rate of diagnosis of combining OCT with fundus photography were respectively 95.0%, 97.5%, 97.4%, 95.1%, and 96.3%, which were significantly higher than OCT or fundus photography alone (P < 0.05); and for combined examination, AUC (95%CI) = 0.963 (0.000–1.000). Conclusion. Combining OCT with fundus photography can effectively identify high myopia patients with retinopathy, which is conducive to improving clinical positive ratio and providing objective basis for treatment.

Assessment of Macular Perfusion in Normal and Myopic eyes by Optical Coherence Tomography Angiography

“…This was also in line with what Hao et al, who examined a group consisting of 40 myopia patients with retinopathy and 40 healthy individuals who were part of the control group during the same time period. The authors' findings showed that the study group's nerve thickness was significantly different from that of the control group in terms of both the nerve thickness above and below the optic disc as well as the temporal and nasal nerve thickness of the optic disc (P < 0.001) [23].…”

Study of Diagnostic Accuracy: Fundus Photography vs. Optical Coherence Tomography

“…It noted that OCT will be added to FP screening for chorioretinal disorders in the future. The studies published to date focus on specific pathologies, such as Jain, N.'s quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs [38], or Hao Y's paper [39], which indicated that the combination of OCT with fundus photography can effectively identify disease. In a study of high levels of myopia, the sensitivity, specificity, PPV, and NPV of OCT combined with fundus photography were more than 94.0%, which were significantly higher than OCT or fundus photography alone (p < 0.05).…”