Value of circulating miRNA-21 in the diagnosis of subclinical diabetic cardiomyopathy

Tao, Ling; Huang, Xiaoli; Xu, Min; Qin, Zihan; Zhang, Feifei; Fang, Hua; Jiang, Xiaohong; Wang, Yuetao

doi:10.1016/j.mce.2020.110944

Cited by 33 publications

(18 citation statements)

References 40 publications

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“…All alphabetical cross references in this figure ( a, b, c … ) are linked to literature reference numbers in the figure legend. The respective references are as follows: a [ 75 ], b [ 83 ], c [ 124 ], d [ 184 ], e [ 85 ], f [ 96 ], g [ 125 ], h [ 88 ], i [ 120 ], j [ 77 ], k [ 86 ], l [ 98 ], m [ 126 ], n [ 185 ], o [ 87 ], p [ 89 ], q [ 90 ], r [ 108 ], s [ 110 ], t [ 111 ], u [ 114 ], v [ 140 ], w [ 141 ], x [ 145 , [148] , [149] , [150] , [151] , [152] ], y [ 160 ], z [ [239] , [240] , [241] ], & [ 187 ]. Open access source for body image can be found at Pixabay ( https://pixabay.com/de/photos/anatomie-frau-mensch-k%C3%B6rper-haut-254120/ ).…”

Section: Discussionmentioning

confidence: 99%

“…MiRNA-1254 was also predictive of ventricular remodeling in patients with ST-segment-elevation MI [ 146 ]. MiRNA-21 was found to be upregulated in murine models for heart failure by Vettori and colleagues [ 147 ] as well as in patients suffering from heart failure [ [148] , [149] , [150] ], subclinical diabetic cardiomyopathy [ 151 ] and diastolic dysfunction [ 152 ]. MiRNA-21 is upregulated in multiple types of human cancer [ 153 ] and cell-growth in general, and consequently linked to cardiac hypertrophy [ 154 ] and vascular neointimal lesion formation [ 155 ].…”

Section: Redox-regulated Micrornas In Human Cardiovascular Diseasementioning

confidence: 99%

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Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

et al. 2021

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Global epidemiological studies show that chronic non-communicable diseases such as atherosclerosis and metabolic disorders represent the leading cause of premature mortality and morbidity. Cardiovascular disease such as ischemic heart disease is a major contributor to the global burden of disease and the socioeconomic health costs. Clinical and epidemiological data show an association of typical oxidative stress markers such as lipid peroxidation products, 3-nitrotyrosine or oxidized DNA/RNA bases with all major cardiovascular diseases. This supports the concept that the formation of reactive oxygen and nitrogen species by various sources (NADPH oxidases, xanthine oxidase and mitochondrial respiratory chain) represents a hallmark of the leading cardiovascular comorbidities such as hyperlipidemia, hypertension and diabetes. These reactive oxygen and nitrogen species can lead to oxidative damage but also adverse redox signaling at the level of kinases, calcium handling, inflammation, epigenetic control, circadian clock and proteasomal system. The in vivo footprints of these adverse processes (redox biomarkers) are discussed in the present review with focus on their clinical relevance, whereas the details of their mechanisms of formation and technical aspects of their detection are only briefly mentioned. The major categories of redox biomarkers are summarized and explained on the basis of suitable examples. Also the potential prognostic value of redox biomarkers is critically discussed to understand what kind of information they can provide but also what they cannot achieve.

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Section: Discussionmentioning

confidence: 99%

Section: Redox-regulated Micrornas In Human Cardiovascular Diseasementioning

confidence: 99%

Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

et al. 2021

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“…In the same context, increased expression of miR-21 has been recognized as responsible for fibroblast activation and development of fibrosis [ 37 ]. Interestingly, a recent study involving asymptomatic patients with type II diabetes demonstrated that miR-21 levels were significantly decreased in patients with cardiac dysfunction in comparison with those without [ 40 ]. Given that diabetic cardiomyopathy affects 12% of diabetic patients and currently lacks a specific biomarker, the opposite behavior of miR-21 in the general and the diabetic populations has important potential implications in the clinical setting [ 40 ].…”

Section: Non-coding Rnasmentioning

confidence: 99%

“…Interestingly, a recent study involving asymptomatic patients with type II diabetes demonstrated that miR-21 levels were significantly decreased in patients with cardiac dysfunction in comparison with those without [ 40 ]. Given that diabetic cardiomyopathy affects 12% of diabetic patients and currently lacks a specific biomarker, the opposite behavior of miR-21 in the general and the diabetic populations has important potential implications in the clinical setting [ 40 ]. Further, supporting the therapeutic potential of miR-21 as a cardiac biomarker, Tao et al reported that overexpression of miR-21 improved mitochondrial biogenesis and reduced cell apoptosis in animal models [ 40 ].…”

Section: Non-coding Rnasmentioning

confidence: 99%

Traditional and Emerging Biomarkers in Asymptomatic Left Ventricular Dysfunction—Promising Non-Coding RNAs and Exosomes as Biomarkers in Early Phases of Cardiac Damage

Janjusevic

Fluca

Ferro

et al. 2021

IJMS

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Heart failure (HF) is one of the major causes of morbidity and mortality worldwide and represents an escalating problem for healthcare systems. The identification of asymptomatic patients with underlying cardiac subclinical disease would create an opportunity for early intervention and prevention of symptomatic HF. Traditional biomarkers are very useful as diagnostic and prognostic tools in the cardiovascular field; however, their application is usually limited to overt cardiac disease. On the other hand, a growing number of studies is investigating the diagnostic and prognostic potential of new biomarkers, such as micro-RNAs (miRNA), long non-coding RNAs, and exosome cargo, because of their involvement in the early phases of cardiac dysfunction. Unfortunately, their use in asymptomatic phases remains a distant goal. The aim of this review is to gather the current knowledge of old and novel biomarkers in the early diagnosis of cardiac dysfunction in asymptomatic individuals.

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“…Meanwhile, it can regulate many signal transduction pathways and involves in endothelial cell differentiation, migration and angiogenesis. [ 13 – 16 ] Therefore, it is significant in cardiovascular system. It can be interesting to apply it as a biomarker, especially for cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of miRNA-21 on coronary restenosis after percutaneous coronary intervention in patients with coronary heart disease

et al. 2021

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Background: Evidence reveals that microRNA (miRNA) can predict coronary restenosis in patients suffering from coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Perhaps, miRNA-21 is a promising biomarker for the diagnosis of coronary restenosis after PCI. However, the accuracy of miRNA-21 has not been systematically evaluated. Therefore, it is necessary to perform meta-analysis to certify the diagnostic values of miRNA-21 on coronary restenosis after PCI. Methods: China National Knowledge Infrastructure, Wanfang, VIP, and China Biology Medicine disc, PubMed, EMBASE, Cochrane Library, and Web of Science were searched for relevant studies to explore the potential diagnostic values of miRNA-21 on coronary restenosis after PCI from inception to January 2021. All data were extracted by 2 experienced researchers independently. The risk of bias about the meta-analysis was confirmed by the Quality Assessment of Diagnostic Accuracy Studies-2. The data extracted were synthesized and heterogeneity was investigated as well. All of the above statistical analyses were carried out with Stata 16.0. Results: This study proved the pooled diagnostic performance of miRNA-21 on coronary restenosis after PCI. Conclusion: This study clarified confusions about the specificity and sensitivity of miRNA-21 on coronary restenosis after PCI, thus further guiding their promotion and application. Ethics and dissemination: Ethical approval is not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms. This review would be disseminated in a peer-reviewed journal or conference presentations. OSF Registration Number: DOI 10.17605/OSF.IO/356QK.

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Value of circulating miRNA-21 in the diagnosis of subclinical diabetic cardiomyopathy

Cited by 33 publications

References 40 publications

Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

Traditional and Emerging Biomarkers in Asymptomatic Left Ventricular Dysfunction—Promising Non-Coding RNAs and Exosomes as Biomarkers in Early Phases of Cardiac Damage

Predictive value of miRNA-21 on coronary restenosis after percutaneous coronary intervention in patients with coronary heart disease

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