Value of Bile-Acid Binding Agents in Post-Vagotomy Diarrhœa

Taylor, T. V.; Lambert, Mark E.; Torrance, H B

doi:10.1016/s0140-6736(78)91139-x

Cited by 26 publications

(8 citation statements)

References 8 publications

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“…Ad ministration of aluminium hydroxide, another common modality of therapy in dialyzed patients, may have effects on serum lipids. It has been shown that Al (OH)» binds bile acids in the intestine [33,34]; under acute nonsteady state conditions we found an increase in fecal sterols and bile acids upon administration of Al (OH).» [unpubl. ob servations], The influence, if any, of intestinal sequestration of sterols and bile acids on serum lipids remains to be determined.…”

Section: Lipid and Lipoprotein Patterns In Uremiamentioning

confidence: 85%

Hyperlipoproteinemia in Renal Insufficiency

Heuck

Ritz²

1980

Nephron

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In uremic patients, hyperlipoproteinemia is common, but its role as a risk factor in atherogenesis remains controversial. The main abnormality appears to be diminished catabolism of lipoproteins in the face of unchanged or low hepatic synthesis. The relation of diminished catabolism to reduced postheparin lipolytic activity and selective deficiency of hepatic triglyceride lipase remains to be established. Hyperlipoproteinemia in uremic patients, most commonly of the type IV variety, responds to dietary methods (reduction of carbohydrate content, increase in P/S ratio) or pharmacological intervention. Guidelines for therapy remain controversial in view of the uncertainty about the pathogenic role of hyperlipoproteinemia in atherogenesis.

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Section: Lipid and Lipoprotein Patterns In Uremiamentioning

confidence: 85%

Hyperlipoproteinemia in Renal Insufficiency

Heuck

Ritz²

1980

Nephron

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“…The altered antral and intestinal motility or changes in bile composition after truncal vagotomy may be precipitating factors. The operation of these mechanisms derives support from the protection afforded by bile acid-binding agents [16]. By preserving the vagal innervation of the extragastric viscera and by achieving a more normal pattern of gastric emptying [4], HSV results in a lower incidence of postvagotomy diarrhea even if cholecystectomy is added.…”

Section: Discussionmentioning

confidence: 99%

Highly selective vagotomy combined with cholecystectomy: Is there an increased risk of diarrhea?

Schein

1989

World j. surg.

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The addition of cholecystectomy to truncal vagotomy and a drainage procedure increases the incidence and severity of postvagotomy diarrhea. This study attempts to establish whether diarrhea is more common after highly selective vagotomy (HSV) and cholecystectomy than after HSV alone. The incidence of diarrhea in 729 patients who underwent HSV without cholecystectomy was found to be 8.8% whereas, in 66 patients in whom HSV was combined with cholecystectomy, the incidence of diarrhea was 9.3%. In most patients, the diarrhea was very mild and in none was it severe. We conclude that the addition of cholecystectomy to HSV does not result in an increased incidence of diarrhea.

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“…The bile acid binding compound, cholestyramine, lowers LDL cholesterol. Also antacids have been claimed to have this ability (41,49). Males, but not females, treated with antacids indeed had lower LDL.…”

Section: Pharmacotherapymentioning

confidence: 99%

The Uremic Dyslipoproteinemia: Its Characteristics and Relations to Clinical Factors

Norbeck

Carlson

1981

Journal of Internal Medicine

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ABSTRACT. Fasting concentrations of cholesterol and triglycerides were determined in total serum and in serum fractions of very low (VLDL), low (LDL) and high (HDL) density lipoproteins in 141 patients with chronic renal failure (CRF) of different etiologies. They were grouped according to sex and degree of renal failure. The characteristic dyslipoproteinemia of uremia, viz. hypertriglyceridemia, raised VLDL and low HDL, cholesterol enrichment of VLDL and triglyceride enrichment of LDL, was present already in the mildest, asymptomatic group (creatinine 140–400 μmol/l), highly significant for men (n=28) but not statistically significant for women (n=7). There was a negative correlation between creatinine and LDL cholesterol concentrations and between creatinine and the cholesterol/triglyceride ratio in LDL in males, otherwise the degree of renal insufficiency did not influence the dyslipoproteinemia. Neither different etiologies of CRF, nor treatment with β‐adrenergic blocking agents or thiazides did seem to influence lipoprotein levels orderly. Males on antacids had lower serum and LDL cholesterol levels, which is probably explained by the negative relation between LDL cholesterol and creatinine, as antacids are more often administered in advanced uremia. Males treated with protein‐poor diet differed from other groups by not having elevated VLDL triglycerides. It is concluded that the lipoprotein abnormalities found in uremia are present already at an early stage of renal impairment and, except for LDL cholesterol in males, fairly uninfluenced by the degree of renal function and etiology of the disease. It is suggested that the dyslipoproteinemia of CRF is caused by effects on several mechanisms in lipoprotein metabolism, e.g. deficiency of different apolipoproteins.

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Value of Bile-Acid Binding Agents in Post-Vagotomy Diarrhœa

Cited by 26 publications

References 8 publications

Hyperlipoproteinemia in Renal Insufficiency

Hyperlipoproteinemia in Renal Insufficiency

Highly selective vagotomy combined with cholecystectomy: Is there an increased risk of diarrhea?

The Uremic Dyslipoproteinemia: Its Characteristics and Relations to Clinical Factors

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