Value of Albumin–Globulin Ratio as a Predictor of All-Cause Mortality After Non-ST Elevation Myocardial Infarction

Abstract

Low albumin and the albumin-globulin ratio (AGR) were associated with vascular adverse events. Our study explores the AGR as a predictor of mortality after non-ST-segment elevation myocardial infarction (NSTEMI). In an observational study of 570 NSTEMI patients admitted to a tertiary center between 2004 and 2006, patients were stratified into equal tertiles according to AGR. The primary outcome was 4-year all-cause mortality. The 4-year mortality rates in the first, second, and third AGR tertiles were 88 (47%) of 189, 48 (25%)of 190 , and 19 (10%) of 191, respectively (P < .0001). After adjusting for 20 confounding variables, AGR first tertile (AGR <1.12) had a higher mortality versus second tertile (hazard ratio [HR] 2.6, P < .001). Likewise, the AGR second tertile had higher mortality versus the third tertile (AGR ≥1.34; HR 2.3, P = .004). The albumin-globulin ratio is a significant independent predictor of long-term mortality after NSTEMI in patients with normal serum albumin levels. Further studies are needed to explain the underlying mechanisms.

Ischemic aetiology, self-reported frailty, and gender with respect to cognitive impairment in chronic heart failure patients

“…Hypoalbuminemia, previously considered a mortality predictor following myocardial infarction [44], has also been reported to be predictive of 1 year mortality among heart failure patients [45]. Classically linked to frailty, in our sample, albumin levels appeared to be related to CI.…”

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

“…In addition to the suggested genetic correlations in Europeans (type 2 diabetes and BMI; triglycerides, blood sugar, and hemoglobin A1c; coronary artery disease and BMI; and high-density-lipoprotein cholesterol and triglycerides) 15 , we empirically corroborated novel genetic correlations that have been implicated in Mendelian randomization analyses (e.g., type 2 diabetes and alanine aminotransferase 31 ; atrial fibrillation and height 32 ; asthma and eosinophil count 9 ; and colorectal cancer and height 33 ) and epidemiological studies (e.g., ischemic stroke and uric acid 34 ; myocardial infarction and albumin/globulin ratio 35 ; peripheral artery disease and total Tables 1 and 2. bilirubin 36 ; and urolithiasis and blood pressure 37 ) (Supplementary Table 8). Thus, we further investigated causal relationships between the significant pairs of quantitative traits and diseases by using a Mendelian randomization approach (Methods).…”

Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

“…These findings are consistent with the previous studies [19,25]. Beamer et al found diabetes was more common in patients with lower AGR and presumed low AGR as a marker of severity of the pathophysiological changes related to chronic disease, such as diabetes [25].…”

“…The association of AGR and mortality had been reported by previous studies on varied populations, including non-ST elevation myocardial infarction [19], colorectal cancer [20,21], hepatocellular carcinoma [22], and early-stage non-small cell lung cancer [23]. Suh et al reported low AGR was a risk factor for cancer incidence and mortality, both in the short-and long terms, in 26,974 healthy patients [24].…”