Value of a single C-reactive protein measurement at 18 h of age

Lacaze‐Masmonteil, Thierry; Rosychuk, Rhonda J.; Robinson, Joan

doi:10.1136/archdischild-2013-303984

Cited by 37 publications

(23 citation statements)

References 21 publications

(9 reference statements)

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“…found that a cut‐off of 0.5 mg/dL had a sensitivity and specificity of 70% and 91%, respectively . In early‐onset sepsis, however, CRP at the time of initial evaluation has a low sensitivity and PPV . In the present study, a cut‐off of 0.16 mg/dL for CRP had 75.0% sensitivity and 76.3% specificity for proven sepsis.…”

Section: Discussionmentioning

confidence: 44%

“…19 In early-onset sepsis, however, CRP at the time of initial evaluation has a low sensitivity and PPV. 20 In the present study, a cut-off of 0.16 mg/dL for CRP had 75.0% sensitivity and 76.3% specificity for proven sepsis. The presence of early-onset sepsis may have possibly affected the results, because patients with early-onset sepsis had significantly lower CRP compared with those with late-onset sepsis ( Table 5).…”

Section: Discussionmentioning

confidence: 75%

See 1 more Smart Citation

Efficacy of new leukocyte parameters versus serum C‐reactive protein, procalcitonin, and interleukin‐6 in the diagnosis of neonatal sepsis

Çelik

Portakal

Yiğit

et al. 2016

Pediatrics International

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Although the predictive value of leukocyte parameters including neutrophil and monocyte volume, conductivity, scattering and volume distribution width in the diagnosis of neonatal sepsis was lower than that of CRP, PC and IL-6, some of these new parameters may be useful in the differential diagnosis of newborn sepsis, along with the other screening tools. In particular, MNV seems to be the most useful parameter with the highest specificity; also, the importance of PC in the diagnosis of early onset sepsis was confirmed.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 75%

Efficacy of new leukocyte parameters versus serum C‐reactive protein, procalcitonin, and interleukin‐6 in the diagnosis of neonatal sepsis

Çelik

Portakal

Yiğit

et al. 2016

Pediatrics International

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“…consistently associated with poor prognosis. These findings were in comparison with other studies [29][30][31][32]. The higher the score, the greater was the likelihood of sepsis.…”

Section: Resultssupporting

confidence: 49%

Study of the hematological scoring system and C-reactive protein (CRP) in determining Neonatal sepsis

Godbole

Joshi

Jaison

2020

Trop J Pathol Microbiol

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Background: Laboratory sepsis markers play an important role in the assessment of a neonate with clinical signs of a probable infection with. C-reactive protein (CRP), Blood culture (BC), Hematological Scoring System (HSS) are three well-identified parameters designated for the investigation of Neonatal Sepsis or infection. Material and Methods: The current study was a prospective hospital-based cross-sectional study carried out at the Department of Pathology, MIMER Medical College, Talegaon (D), Maharashtra, India. Neonates with features suggestive of sepsis and Neonates with recent maternal infection were included in the study. Sensitivity, specificity, Positive Predictive Values (PPVs) and Negative Predictive Values (NPVs) were calculated for each parameter. Results: A total of 40 neonates suspected of having sepsis were enrolled in the current study. In the current study, blood culture was positive in 10 cases (25%), out of which 6 (60%) were Grampositive and 4 (40%) were Gram-negative, whereas 30 cases were found to be negative for blood culture. The mean CRP levels in positive culture cases were 85.7±17, whereas, in the negative culture case, the mean CRP Levels were 38.7±23, whereas the mean value in control was 5.88±0.72. Conclusion: HSS is a simple, easy, cheap, and rapid adjunct for the diagnosis of clinically suspected cases of neonatal sepsis. C-reactive protein values correlate well with HSS in predicting sepsis. However, C-reactive protein does not have any advantage over HSS, either as a single test or in combination.

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“…Thus, its sensitivity as a biomarker for EOS varies from 29 to 90%. PCT serum levels rise faster than CRP, but the initial reports of sensitivity close to 100% have not been confirmed by subsequent evaluations [15,19,20]. The complex pathophysiological mechanisms of sepsis involve inflammation and endothelial activation as critical determinants of the host response, leading to the hypothesis that biomarkers of endothelium dysfunction might be used as clinical tools in the diagnosis and follow-up of sepsis [21].…”

Section: Discussionmentioning

confidence: 99%

Endocan serum concentration in uninfected newborn infants

Zonda

Zonda²,

Cernomaz

et al. 2019

J Infect Dev Ctries

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Introduction: Endocan is a specific endothelial mediator involved in the inflammatory response. Its role in the diagnosis of sepsis has been studied in adult patients and late onset neonatal sepsis. The clinical signs of early onset sepsis (EOS) are nonspecific and routinely used biomarkers, such as C-reactive protein and procalcitonin, have low sensitivity, specificity and positive predictive value. Endocan could be useful as a biomarker for diagnosis of EOS, but at present normal range values for this molecule have not been reported. The aim of this study is to establish the normal values range for serum endocan in term and preterm newborns without risk factors for EOS and to characterize the variation pattern of its levels at different postnatal moments. Methodology: Mean endocan serum concentration (ESC) was measured in term and preterm newborns without clinical suspicion of EOS at different moments from birth. Results: ESC (ng/mL) in term newborns was 1.74+/-0.13 on day 1 and 2.02+/-0.41 on day 3 respectively, (p=0.09). In preterm newborns ESC (ng/mL) was 2.02+/-0.11 and 1.97+/-0.18, (p=0.8) for day 1 and 3 respectively. ESC was not significantly influenced by sex, mode of delivery, evidence of fetal distress or presence of minor birth trauma. Conclusions: ESC (ng/mL) between the first and third day of life in either term or preterm infants don’t appear to be significantly influenced by factors that are associated with elevation of inflammatory markers, thus using this biomarker for the diagnosis of EOS might reduce the false positive results.

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Value of a single C-reactive protein measurement at 18 h of age

Cited by 37 publications

References 21 publications

Efficacy of new leukocyte parameters versus serum C‐reactive protein, procalcitonin, and interleukin‐6 in the diagnosis of neonatal sepsis

Efficacy of new leukocyte parameters versus serum C‐reactive protein, procalcitonin, and interleukin‐6 in the diagnosis of neonatal sepsis

Study of the hematological scoring system and C-reactive protein (CRP) in determining Neonatal sepsis

Endocan serum concentration in uninfected newborn infants

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