Value of a New QT Interval Correction Formula in Adjusting for Increases in Heart Rate

Abstract

identification of individuals with genetic mutations that carry a high risk of sudden death [5]. A new QT-heart rate correction formula (QTc) has been developed based on ECGs from about 13,600 individuals in the NHANES US population study [6]. This QTc was shown to be was superior to other formulae [6,7]. The value of this approach, however, has not been tested in the same individual under different conditions of heart rate stress.A critical aspect of the evaluation of the QT interval is its adjustment for heart rate because of the recognized inverse relationship between QT interval and heart rate. Studies that established QTc formulae including the most recent one, utilized data on different individuals who have different heart rates. While there is considerable power in the large numbers of individuals from population based studies, they do not address between individual variability. Specifically these studies are not able to take into consideration variables that produce different resting heart rates that might in turn influence the QT interval. The importance of the individual responses to test the robustness of the QT-heart rate correction formulae is well recognized [8]. The new QT-heart rate adjustment formula has not been subject to protocol driven changes in heart rate to determine whether QTc is stable when heart rate is increased. The objective of this study was to examine the new QT correction formula for its ability to remain stable in the same individual across a range of heart rates. Methods PopulationThe patient population were individuals who reAbstract Background and objective: QT interval correction for heart rate (QTc) is essential for clinical usage. A new QTc formula has been developed based on a data agnostic mathematical approach in a large population ECG data base. The formula requires testing on a within individual basis under conditions of intervention to increase heart rate. The objective of this study was to examine the stability and reliability the new QTc formulae within individuals when Heart Rate (HR) is increased by dobutamine.

Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug‐induced heart rate changes

“…17 Further, this QTcSPL method has been shown to be more robust to drug and externally induced changes in HR than standard correction methods. 19,20 Subsequently, the QTcSPL method may offer an alternative to subject-specific correction methods in the presence of drug-induced changes in HR.…”

“…These studies collected 13,627 ECGs across participants aged 18 to 90 years over a wide distribution of HR ranges (40–120 bpm), and showed better ability to reduce the relationship between HR and QTc over six common correction methods 17 . Further, this QTcSPL method has been shown to be more robust to drug and externally induced changes in HR than standard correction methods 19,20 . Subsequently, the QTcSPL method may offer an alternative to subject‐specific correction methods in the presence of drug‐induced changes in HR.…”