Value of [68Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

Zhou, Yue; Yang, Xin; Liu, Huipan; Luo, Wenbin; Liu, Hanxiang; Lv, Taiyong; Wang, Junzheng; Qin, Jianhua; Ou, Santao; Chen, Yue

doi:10.1007/s00259-021-05343-x

Cited by 74 publications

(65 citation statements)

References 39 publications

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“…Fibrosis markers are needed in the evaluation of schistosomiasis: in this context, an interesting PET radiopharmaceutical may be represented by 68 Ga-labeled fibroblast activation protein inhibitor ( 68 Ga-FAPI), a recent tracer that targets the fibroblast activation protein [ 91 ]; this radiopharmaceutical has been used to assess the degree of fibrosis in organs such as liver and kidneys [ 91 , 92 ] and potentially it may be useful for the assessment of fibrosis induced by schistosomiasis.…”

Section: Discussionmentioning

confidence: 99%

Medical Imaging in the Diagnosis of Schistosomiasis: A Review

et al. 2021

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Schistosomiasis is one of the most important parasitic diseases and it is endemic in tropical and subtropical areas. Clinical and laboratory data are fundamental for the diagnosis of schistosomiasis, but diagnostic imaging techniques such as x-rays, ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) may be helpful in the evaluation of disease severity and complications. In this context, the aim of this review is to explore the actual role of diagnostic imaging in the diagnosis of schistosomiasis, underlining advantages and drawbacks providing information about the utilization of diagnostic imaging techniques in this context. Furthermore, we aim to provide a useful guide regarding imaging features of schistosomiasis for radiology and nuclear medicine physicians of non-endemic countries: in fact, in the last years non-endemic countries have experienced important flows of migrants from endemic areas, therefore it is not uncommon to face cases of this disease in daily practice.

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Section: Discussionmentioning

confidence: 99%

Medical Imaging in the Diagnosis of Schistosomiasis: A Review

et al. 2021

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“…A 65-year-old woman with rectal cancer showed enhanced 68 Ga-FAPI uptake in her sacroiliac and costal joints, suggesting that she had sacroiliac arthritis and spondylitis, while 18 F-FDG PET/CT found no abnormal lesions on the bone ( 66 ). MIP images of a 49-year-old male patient showed increased FAPI intake in the middle abdomen, which was followed by a pathological diagnosis of benign enteric inflammatory myofibrolastoma ( 67 ). Scholars have also found that FAPI-guided radiation therapy may reduce selective lymph node irradiation, thereby avoiding tumor recurrence and improving overall survival.…”

Section: Organs Of the Abdominal Cavitymentioning

confidence: 99%

“…The SUV max of the patients with mild, moderate, and severe fibrosis were 3.92 ± 1.50, 5.98 ± 1.6 and 7.67 ± 2.23, respectively. Thus, in comparison with renopuncture examinations, 68 Ga-FAPI-04 PET/CT showed bilateral kidneys more quickly and sensitively, which can, in turn, help assess disease progression, diagnosis, and treatment planning ( 67 ).…”

Section: Organs Of the Abdominal Cavitymentioning

confidence: 99%

FAPI PET/CT in the Diagnosis of Abdominal and Pelvic Tumors

Yang

Hou

et al. 2022

Front. Oncol.

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Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) is currently a standard imaging examination used in clinical practice, and plays an essential role in preoperative systemic evaluation and tumor staging in patients with tumors. However, 18F-FDG PET/CT has certain limitations in imaging of some tumors, like gastric mucus adenocarcinoma, highly differentiated hepatocellular carcinoma, renal cell carcinoma, and peritoneal metastasis. Therefore, to search for new tumor diagnosis methods has always been an important topic in radiographic imaging research. Fibroblast activation protein (FAP) is highly expressed in many epithelial carcinomas, and various isotope-labelled fibroblast activation protein inhibitors (FAPI) show lower uptake in the brain and abdominal tissues than in tumor, thus achieving high image contrast and good tumor delineation. In addition to primary tumors, FAPI PET/CT is better than FDG PET/CT for detecting lymph nodes and metastases. Additionally, the highly selective tumor uptake of FAPI may open up new application areas for the non-invasive characterization, staging of tumors, as well as monitoring tumor treatment efficacy. This review focuses on the recent research progress of FAPI PET/CT in the application to abdominal and pelvic tumors, with the aim of providing new insights for diagnostic strategies for tumor patients, especially those with metastases.

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“…We purchased the precursor FAPI-04 from MCE (MedChemExpress, USA), with a purity of 98% and a quality of 872.91. The 68 Ga-FAPI labeling was carried out according to the method described previously [9]. The radiochemical purity of 68 Ga-FAPI exceeded 95%.…”

Section: Ga-fapi Pet/ctmentioning

confidence: 99%

The Clinical Value of 68Ga-FAPI-04 PET/CT on Detection of Lymph Node Metastasis and Staging for Esophageal Carcinoma

Xiao-mi

You

et al. 2021

Preprint

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Purpose To observe the clinical application value of 68Ga-FAPI-04 PET/CT in the preoperative detection of lymph node metastasis and staging of esophageal cancer.Methods A prospective analysis of 29 surgical patients was performed. 68Ga-FAPI-04 PET/CT was performed within 1 week before the operation. All patients received enhanced CT during the same period. None of these patients had received preoperative treatment before the operation. The value of 68Ga-FAPI-04 PET/CT and enhanced CT in the diagnosis of lymph node metastasis and preoperative staging of esophageal cancer was compared according to postoperative pathology.Results Both 68Ga-FAPI-04 PET/CT and CT detected the primary tumor (29/29 cases). 637 lymph nodes were surgically removed, of which 37 lymph nodes were metastasized. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of PET/CT for lymph node metastasis detection were 71.1%, 99.4%, 97.8%, 90.0%, and 98.2%; The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of CT for lymph node metastasis detection were 36.8%, 98.9%, 95.3%, 70.0%, and 96.1%, respectively.Conclusion 68Ga-FAPI-04 PET/CT is better than enhanced CT in diagnosing lymph node metastasis and determining lymph node staging in esophageal cancer.

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Value of [68Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

Cited by 74 publications

References 39 publications

Medical Imaging in the Diagnosis of Schistosomiasis: A Review

Medical Imaging in the Diagnosis of Schistosomiasis: A Review

FAPI PET/CT in the Diagnosis of Abdominal and Pelvic Tumors

The Clinical Value of 68Ga-FAPI-04 PET/CT on Detection of Lymph Node Metastasis and Staging for Esophageal Carcinoma

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