Value of 3-T Multiparametric Magnetic Resonance Imaging and Magnetic Resonance–Guided Biopsy for Early Risk Restratification in Active Surveillance of Low-Risk Prostate Cancer

Abstract

Application of MP-MRI and MRGB in active surveillance may contribute in early identification of patients with GGP 4 or 5 containing cancers at 3 months of follow-up. If, during further follow-up, a PI-RADS score of 1 or 2 continues to have a negative predictive value for GGP 4 or 5 containing cancers, a PI-RADS standardized reported MP-MRI may be a promising tool for the selection of prostate cancer patients suitable for active surveillance.

Interobserver Reproducibility of the PI-RADS Version 2 Lexicon: A Multicenter Study of Six Experienced Prostate Radiologists

“…Without correcting for multiple comparisons, six features showed an increase in percent agreement and six features showed a decrease in percent agreement between the two sessions. When corrected for multiple On the basis of the pathologic results in the 63 patients who underwent subsequent MR imaging and US fusionguided biopsy (Table 3) 17], and by all six readers in 76.5% [13 of 17]). Among lesions classified as PI-RADS assessment category of 4 or greater by a majority of readers, 67.6% (25 of 37) were Gleason score of 3+3 or greater and 45.9% (17 of 37) were Gleason score of 3+4 or greater.…”

“…To facilitate comparison of interreader agreement between features, all measures were evaluated in a binary fashion. Accordingly, lesion size was evaluated in terms of whether or not it was at least 15 mm (corresponding with the size threshold used in PI-RADS V2), and scores of 1-5 were evaluated in terms of whether or not these scores were at least 3 and at least 4 (both of which have been applied in the literature as clinically relevant thresholds [17,18]). …”

Surface-enhanced Raman spectroscopy of serum accurately detects prostate cancer in patients with prostate-specific antigen levels of 4–10 ng/mL

“…[8][9][10][11] After diagnosis, a crucially important issue is to assess aggressiveness of cancer, so as to discriminate indolent PCa from aggressive ones, enabling the doctors to discriminate patients suitable for active surveillance from those who need radical prostatectomy. 12 The Gleason score (GS) of prostate biopsy specimens diagnosed by pathologists is of crucial importance to assess aggressiveness of PCa; however, several studies revealed discrepancies of GS between biopsy specimens and the corresponding radical prostatectomy specimens. 13 This leads to a large number of overtreatment of indolent PCa.…”

Active Surveillance in Prostate Cancer

“…Mp-MRG yüksek dereceli PK'de yüksek sensitivite ve spesifiteye sahip olduğundan dolayı Aİ düşünülen hastaların tanı anında hastalığın yanlış sınıflandırılmasını önlemede, hasta seçimi ve takibinde oldukça önemlidir (36). Aİ'de mp-MRG'nin değeri hakkında birçok yayın mevcut olmasına rağmen hiçbiri MRG'yi tedavi endikasyonu olarak kullanmamıştır.…”