Value of 18F-FDG PET in the detection of peritoneal carcinomatosis

Suzuki, Akiko; Kawano, Tsuyoshi; Takahashi, Nobukazu; Jin, Lijun; Nakagami, Yoshihiro; Miyagi, Etsuko; Hirahara, Fumiki; Togo, Shinji; Shimada, Hiroshi; Inoue, Tomio

doi:10.1007/s00259-004-1577-y

Cited by 77 publications

(45 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…FDG PET and CT had a sensitivity of 66.7%, specificity of 94.1%, and PPV of 92.3%. These results provide important information to the management of patients with peritoneal carcinomatosis [19] .…”

Section: Discussionmentioning

confidence: 99%

FDG PET/CT detected an insidious inguinal canal metastasis in a patient with pancreatic cancer

Ong

Yıldız

Kostakoğlu

2012

JBGC

View full text Add to dashboard Cite

A 70 year old male with a history of inoperable pancreatic cancer with peritoneal metastases was evaluated by FDG PET/CT imaging for disease extent and therapy response after 4 cycles of chemotherapy. PET/CT demonstrated mildly increased uptake at the primary site within the pancreatic neck and in the peritoneum. An unexpected finding involved increased uptake in the right inguinal canal region around the patient's known hernia. A hernia inflammation was suspected and the patient subsequently underwent surgical intervention for possible strangulation. Unexpectedly, the histopathologic evaluation of the surgical specimen revealed peritoneal metastasis in the inguinal canal. Although metastasis to this localization is rather rare, the use of PET/CT assisted in the discovery of unexpected metastasis in a rare location.

show abstract

Section: Discussionmentioning

confidence: 99%

FDG PET/CT detected an insidious inguinal canal metastasis in a patient with pancreatic cancer

Ong

Yıldız

Kostakoğlu

2012

JBGC

View full text Add to dashboard Cite

show abstract

“…A recent study has demonstrated that the routine use of FDG PET is unsuitable as a diagnostic imaging procedure for lesion characterization, evaluation of the extent of the disease and the relationship with the adjacent organs (34). More recently, several studies examining the detection of peritoneal carcinomatosis by PET have demonstrated that the use of combined PET and CT showed a sensitivity of 67-78% and a PPV of 92-95% (24,25).…”

Section: Discussionmentioning

confidence: 99%

“…Some investigations have shown that the use of PET does not improve the diagnostic accuracy, while others have shown that PET can supplement the information obtained by CT and MRI (19)(20)(21)(22)(23). Some recent studies have demonstrated that for peritoneal carcinomatosis, the use of combined PET and CT may play an important role in the clinical management of patients (24,25). However, to the best of our knowledge, there are few reports that have examined a comparison of the use of MRI and integrated PET/CT to predict the presence of peritoneal carcinomatosis resulting from primary ovarian cancer (26).…”

mentioning

confidence: 99%

Comparison of the MRI and Integrated PET/CT Findings in the Preoperative Detection of Peritoneal Carcinomatosis Arising from Primary Ovarian Cancer

Kim

Park

Choi

et al. 2009

J Korean Soc Radiol

View full text Add to dashboard Cite

Purpose:To compare the diagnostic performance of MRI and integrated PET/CT for the preoperative detection of peritoneal carcinomatosis arising from primary ovarian cancer. Materials and Methods: Twenty-three patients with suspected ovarian tumors underwent a contrast-enhanced 1.5 Tesla MRI and a 18F-fluorodeoxyglucose (FDG) PET/CT prior to surgery. The peritoneal cavity was subdivided into six specific sites for a lesion-based analysis. The imaging findings were compared statistically with the histopathological findings using McNemar's test with Bonferroni's adjustment and generalized estimation equations. Results:The histopathological results of all 23 patients were confirmed for primary malignant epithelial ovarian cancer. Of the 23 patients, 19 had a total of 83 sites with peritoneal seedings throughout the abdomen and pelvis. The comparison of the patient-based sensitivity, specificity and accuracy of the use of MRI versus PET/CT for the detection of peritoneal carcinomatosis were 95% versus 84% (p > 0.05; N.S.), 50% versus 50% (p > 0.05; N.S.), and 87% versus 78% (p > 0.05; N.S.), respectively. Moreover, the comparison of the lesion-based sensitivity, specificity and accuracy of MRI versus integrated PET/CT were 86% and 75% (p = 0.004), 76% and 84% (p > 0.05; N.S.), and 82% and 78% (p > 0.05; N.S.), respectively. Conclusion: We found that MRI was more sensitive than integrated PET/CT for the detection of preoperative peritoneal carcinomatosis arising from primary ovarian cancer.

show abstract

“…Scintigraphic signs: focal uptake [13], diffuse peri-hepatic curvilinear uptake [11], sub parietal (epiploic) uptake or the presence of a straight line sign [15,16]; and morphologic signs: peritoneal nodal tissue, fat infiltration, epiploic thickening, ascite [17]. The two reviewers looked for lesions across the whole of the peritoneal cavity with particular attention to the level of the left and right paracolic gutter, the peri-hepatic area, the pelvis and the omentum.…”

Section: Signs Indicating Pc Werementioning

confidence: 99%

“…Promising results highlight the use of 18F-FDG PET to evaluate PC extension pre-operatively [7,8] although only a few reports have been published on the diagnostic performance of 18F-FDG PET/CT. Sensitivities reported have varied from unacceptably low (35%) to 100% [7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of (18) F-FDG PET/CT for the detection of peritoneal carcinomatosis of colorectal origins

Bullier¹,

Descat²,

Bonichon³

et al. 2013

J Cancer Res Ther

View full text Add to dashboard Cite

Purpose: to evaluate the diagnostic accuracy of (18)F-FDG positron emission tomography/ computerized tomography (PET/CT) for the detection of peritoneal carcinomatosis (PC) of colorectal cancer (CRC). Methods: one hundred and forty six eligible patients referred for a PET/CT to evaluate CRC at a single institution were included consecutively and retrospectively. After joint training on 20 similar patient files, two nuclear physicians reviewed the PET/CT scans blindly and independently using a method specifically designed for PC detection. The gold standard was either histological results from surgical exploration for resected patients (n=65) or clinical follow up defined as the 3-month CT follow up supplemented by one year of clinical information and CT monitoring for non-resected patients (n=81). As secondary objectives we evaluated the interobserver reliability between the two PET/CT readings and the diagnostic accuracy of a contemporary ceCT (n=69) or CT component of the PET/CT (n=77) reviewed by an independent radiologist . The extent of PC according to a simplified Sugarbaker index (PCI) was examined for the operated subgroup, when PCI was available from the surgeon and PET/CT (n=12). Results: according to the gold standard, 35/146 patients had PC (including 19 of 65 patients with histological gold standard and 16 of 81 patients with clinical follow up gold standard). Sensitivity and specificity of PET/ CT were 88% and 96% respectively and positive and negative predictive values and accuracy, 88%, 96% and 94% respectively. For CT alone, the corresponding values were: 68%, 92%, 72%, 90% and 86%. The interobserver agreement for the detection of peritoneal carcinomatosis in PET/CT showed high agreement at 0.91 (Kappa). Median PCI was 3 [range: 1-13] when assessed by surgeons and 4 [range: 1-10] on PET/CT. Focal uptake was the most frequently observed sign on PET. Conclusions: PET/CT appears to be an accurate and reproducible test for PC diagnosis in colorectal cancer using an interpretation method specifically designed for PC detection. To confirm these results and to evaluate peritoneal carcinomatosis extension accurately, a prospective observational study using iodine contrast-enhanced PET/CT as a first imaging technique for pre-operative staging and potentially involving further independent reviewers remains to be undertaken.

show abstract

Value of 18F-FDG PET in the detection of peritoneal carcinomatosis

Abstract: We found that use of an intra-abdominal FDG uptake cut-off value for SUVmax of >5.1 assists in the diagnosis of peritoneal carcinomatosis. FDG PET may play an important role in the clinical management of patients with suspected peritoneal carcinomatosis.

Cited by 77 publications

References 22 publications

FDG PET/CT detected an insidious inguinal canal metastasis in a patient with pancreatic cancer

FDG PET/CT detected an insidious inguinal canal metastasis in a patient with pancreatic cancer

Comparison of the MRI and Integrated PET/CT Findings in the Preoperative Detection of Peritoneal Carcinomatosis Arising from Primary Ovarian Cancer

Diagnostic accuracy of (18) F-FDG PET/CT for the detection of peritoneal carcinomatosis of colorectal origins

Contact Info

Product

Resources

About