Value for Money in H1N1 Influenza: A Systematic Review of the Cost-Effectiveness of Pandemic Interventions

Pasquini-Descomps, Hélène; Brender, Nathalie; Maradan, David

doi:10.1016/j.jval.2016.05.005

Cited by 47 publications

(42 citation statements)

References 45 publications

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“…There are significant evidence gaps around the economics of health emergency and disaster risk management. Of the economic studies available before the onset of the COVID‐19 pandemic, many did not incorporate economic evaluations, use a societal perspective, or focused on settings in low‐ and middle‐income countries 3‐5 . In the few cases where research projects have been set up to rapidly respond to the emergence of health emergencies, economic studies have been conspicuously absent 37 …”

Section: What Economic Studies Can Domentioning

confidence: 99%

“…Many studies are focusing on the economic impacts associated with the COVID‐19 pandemic, and the costs and consequences of responses targeted to minimize them 2 . Prior to the COVID‐19 pandemic, the economics of sudden‐onset health emergencies and disasters was a rather under‐investigated research area 3‐5 . This is no longer the case 6 .…”

Section: Introductionmentioning

confidence: 99%

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An introduction to economic studies, health emergencies, and COVID‐19

Clarke

2020

J Evidence Based Medicine

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The COVID‐19 pandemic has created widespread harm and disruption. Countries have implemented unprecedented measures to protect the lives and livelihoods of their inhabitants. The scope and composition of these responses are shaped, in part, by research and analysis about the estimated economic impacts of the COVID‐19 Pandemic and proposed responses to it. This analysis outlines basic features and principles involved in economic studies, specifically economic impact studies and economic evaluations, which have formed a significant part of the ever‐increasing evidence base about COVID‐19. This analysis introduces economic studies in this context, highlighting what they can do, their limitations, and key steps involved in conducting them. It highlights examples of economic analysis focused on COVID‐19 and on health emergencies and disasters more broadly. Knowing how economic studies are conducted, and their limitations, will help introduce how their findings can be a useful, usable, and used part of efforts to tackle this global health crisis.

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Section: What Economic Studies Can Domentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An introduction to economic studies, health emergencies, and COVID‐19

Clarke

2020

J Evidence Based Medicine

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“…(IAV) could result in critical health problems, manifested by significant morbidities and mortalities, as well as economic losses due to the high drop in the human work capability and animals production capacity (Iuliano et al, 2018;Pasquini-Descomps, Brender, & Maradan, 2017).…”

Section: Infections Of Humans and Animals By Influenza A Virusmentioning

confidence: 99%

“…Influenza viruses infect human and animal population, causing annual epidemics and occasional pandemics worldwide (Webster & Govorkova, 2014;Wikramaratna & Gupta, 2009). Infections of humans and animals by influenza A virus (IAV) could result in critical health problems, manifested by significant morbidities and mortalities, as well as economic losses due to the high drop in the human work capability and animals production capacity (Iuliano et al, 2018;Pasquini-Descomps, Brender, & Maradan, 2017).…”

Section: Introductionmentioning

confidence: 99%

Identification of lncRNA‐155 encoded by MIR155HG as a novel regulator of innate immunity against influenza A virus infection

Maarouf

Chen

et al. 2019

Cellular Microbiology

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Long noncoding RNAs (lncRNAs) are single-stranded RNA molecules longer than 200 nt that regulate many cellular processes. MicroRNA 155 host gene (MIR155HG) encodes the microRNA (miR)-155 that regulates various signalling pathways of innate and adaptive immune responses against viral infections. MIR155HG also encodes a lncRNA that we call lncRNA-155. Here, we observed that expression of lncRNA-155 was markedly upregulated during influenza A virus (IAV) infection both in vitro (several cell lines) and in vivo (mouse model). Interestingly, robust expression of lncRNA-155 was also induced by infections with several other viruses. Disruption of lncRNA-155 expression in A549 cells diminished the antiviral innate immunity against IAV. Furthermore, knockout of lncRNA-155 in mice significantly increased IAV replication and virulence in the animals. In contrast, overexpression of lncRNA-155 in human cells suppressed IAV replication, suggesting that lncRNA-155 is involved in host antiviral innate immunity induced by IAV infection. Moreover, we found that lncRNA-155 had a profound effect on expression of protein tyrosine phosphatase 1B (PTP1B) during the infection with IAV. Inhibition of PTP1B by lncRNA-155 resulted in higher production of interferon-beta (IFN-β) and several critical interferon-stimulated genes (ISGs). Together, these observations reveal that MIR155HG derived lncRNA-155 can be induced by IAV, which modulates host innate immunity during the virus infection via regulation of PTP1B-mediated interferon response. KEYWORDS influenza A virus, innate immunity, lncRNA, miR-155, MIR155HG, PTP1B List of Abbreviations: 293T, HEK293T/human embryonic kidney cells; A549, human lung epithelial cells; bic, B-cell Integration Cluster; CA/04, A/California/04/2009; DMEM, Dulbecco's modified Eagle's medium; dpi, days post infection; EV, empty vector; FBS, fetal bovine serum; HA, haemagglutination assay; h-lncRNA-155, human lncRNA-155; hpi, hours post infection; IFN, interferon; IFN-β, interferon-beta; IRF3, interferon regulatory factor 3; IRF7, interferon regulatory factor 7; ISGs, interferon-stimulated genes; KO, bic/miR-155 −/− knock out mice; LLC, mouse Lewis lung carcinoma cells; lncRNAs, long noncoding RNAs; NIH/3T3, mouse embryonic fibroblasts; MDA5, antimelanoma differentiation-associated gene 5; MDCK, Madin-Darby canine kidney cells; miR, microRNA; MIR155HG, miR-155 host gene; m-lncRNA-155, bic/mouse lncRNA-155; NP, IAV nucleoprotein; nt, nucleotide; NRAV, negative regulator of antiviral response;PFA, plaque formation assay; PR8, A/Puerto Rico/8/1934; pre-miR-155, precursor miRNA; pri-miRNA, primary-miRNA; PRRs, pattern recognition receptors; PTP1B, tyrosine-protein phosphatase nonreceptor type 1; RAW 264.7, mouse Abelson murine leukaemia virus transformed macrophages; SeV, Sendai virus; SHIP1, Src homology 2-containing inositol phosphatase 1;sh-luc, Sh-luciferase; shRNAs, short hairpin RNAs; siRNA, small interfering RNA; SOCS1, suppressor of cytokine signalling 1; SPF, specific pathogen free; STAT1, signal transducer a...

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“…In addition, there is a need to explore other alternative approaches to assess potential risks posed by the spread of disease outbreaks and to develop risk management strategies to hedge against the impact of pandemics. These strategies include establishing more systematic protocols (Nicoll et al 2010) and building a database of cases for disease surveillance (Gates 2020), streamlining processes for vaccination development and deployment (Jennings et al 2008;Innis et al 2019), putting in place emergency response plans both at the local and national levels (Chambers et al 2012), and instituting cost-effective measures (e.g., hospital quarantines, use of anti-viral stockpiling) drawn from lessons of past experiences (Pasquini-Descomps et al 2017). Furthermore, by utilizing current economic modelling techniques to develop optimization models which can select the most efficient and cost-effective option among available risk management strategies, and harnessing the emergence of big data and the advancements in network analysis, enhanced results can be achieved for better policymaking.…”

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confidence: 99%

Modelling the Economic Impact and Ripple Effects of Disease Outbreaks

Aviso

2020

Process Integr Optim Sustain

103

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The Coronavirus Disease 2019 outbreak has had alarming effects on human lives and the economies of affected countries. With the world's manufacturing hubs experiencing a period of extended factory closures, the economic impact transcends territorial borders via global supply chains. This paper provides a roadmap on how to evaluate the vulnerability that cascades through the supply chain due to a disease outbreak at the firm level, national level, and global scale. The final extent of losses is not yet known, but the development of economic models combined with epidemiological models and network analysis techniques can yield more realistic estimates to select appropriate strategies in a timely manner.

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Value for Money in H1N1 Influenza: A Systematic Review of the Cost-Effectiveness of Pandemic Interventions

Cited by 47 publications

References 45 publications

An introduction to economic studies, health emergencies, and COVID‐19

An introduction to economic studies, health emergencies, and COVID‐19

Identification of lncRNA‐155 encoded by MIR155HG as a novel regulator of innate immunity against influenza A virus infection

Modelling the Economic Impact and Ripple Effects of Disease Outbreaks

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