Value and Interpretation of Resection Margin after a Colonoscopic Polypectomy for Malignant Polyps

Abstract

PurposeThis study was designed to compare the clinicopathologic findings of an endoscopic polypectomy for malignant polyps with subsequent surgery and to evaluate the appropriateness of the pathologic finding criterion of the resection margin as an indicator for surgery in cases of malignant colorectal polyps.MethodsWe examined the clinicopathologic characteristics, complications and prognoses among the patients who underwent a colonoscopic polypectomy in both our hospitals and at other hospitals from April 2003 and April 2010. These patients were divided into two groups, the group (non-operation group) that only underwent a polypectomy (n = 37) and the group (operation group) that underwent a polypectomy with subsequent surgery (n = 33).ResultsThere were no differences between two groups in the ratios of the number of men to the number of women, the ages or the comorbidities. In terms of endoscopic findings, we found no differences between the two groups in the locations of the polyps, the sizes of the polyps, or the presence of stalks. However, ulceration of polyps was higher in the non-operation group (51.5% vs. 21.6%; P = 0.009), as was the case with submucosal invasion (75.8% vs. 16.2%; P < 0.005). When an endoscopic polypectomy was performed, incomplete resection margins and specimens with margins involved occurred more frequently in the operation group (93.9% vs. 51.4%; P < 0.005), but no residual tumor was detected in 31 of 33 (93.9%) patients in that group. One pathologist reviewed the specimens of 54 patients (operation group, 19; non-operation group, 36). Six of the 19 polyps (31.6%) in the operation group and fifteen of the 36 polyps (41.7%) in the non-operation group had a margin without cancer cells.ConclusionWe may accept the criterion of a safe margin, including a coagulation zone. A multidisciplinary approach has to be developed by surgeons, endoscopists and pathologists based on a discussion of the risk factors for the patient before making a decision on the treatment treatment.

Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy

“…62.4% of patients with malignant polyps were males, similar to benign polyps’ group (60.28%); in the literature, the majority of subjects with malignant polyps were males, prevalence ranging from 51–88% [ 19 , 30 , 31 , 32 , 33 , 34 , 35 ]. The presence of three or more polyps is significantly higher in male patients ( p =0.012) and is associated with a higher risk for HGD ( p <0.0001).…”

The Malignant Polyp: Polypectomy or Surgical Resection?

“…In one, all be it small, study 75% of incompletely resected polyps were associated with an adverse outcome. [20] It should be noted that even when incomplete resection is reported, absence of residual disease in the surgical specimen is the rule (94% in one study) rather than the exception [21]. This is likely due to diathermy electrofulguration of the remnant.…”

“…The European recommendations state that tumour cells within 1mm of the margin represents a positive margin [22], with some authors arguing then >2mm represents the true safe margin [21].…”

Near-infrared photoimmunotherapy is effective treatment for colorectal cancer in orthotopic nude-mouse models

“…In addition, PIT has the potential to be useful during endoscopic resections of polyps. Prior studies have demonstrated that 51.3% of patients undergoing polypectomy alone had positive resection margins [18]. Performing PIT to the resection bed after polypectomy can be advantageous to treat residual disease and decrease the rate of recurrence and need for further operation.…”