Valuation system connectivity is correlated with poly-drug use in young adults

Loganathan, Kavinash; Lv, Jinglei; Cropley, Vanessa; Zalesky, Andrew; Ho, Eric Tatt Wei

doi:10.1016/j.neures.2021.06.006

Cited by 3 publications

(1 citation statement)

References 75 publications

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“…The "Stimulants" are the second class of psychoactive medications; they promote alertness, wakefulness, and vigour [7]. In addition, "Opiates" psychoactive medicines are narcotic painkillers that heighten joy or euphoria and have a sedative eff ect [8]. Conclusively, the "Hallucinogens", are psychoactive medications that create hallucinations in which a user may perceive or hear things that are not there [9].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Intravenous Psychoactive Drug Use among Adolescent Females

AK¹,

Metu²,

PC³

2023

J Biomed Res Environ Sci

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Background: In the twenty-first century, female adolescents’ use of intravenous psychoactive substances has become widespread worldwide. For instance, statistics show that 155 and 250 million people between the ages of 15-64 used intravenous psychoactive drugs as of 2008. Examples of intravenous psychoactive drugs taken by people with 15-64 include; Amphetamines, non-prescribed psychoactive prescription drugs, cannabis, cocaine, and opiates. As a result of the preceding, the use of intravenous psychoactive drugs among Female adolescents is a common phenomenon in the 21st century. Aim: To undergo a systematic review on IV psychoactive drugs use, prevalence, causes and effects among adolescent females. Design: A systematic review. Data Sources: Systematic search for worldwide published literature from databases like google scholar, Emerald, PubMed, and science-direct. Study Eligibility Criteria: Articles that are published in English, primary research and studies published within the last 10 (ten) years (2013-2023). Results: From the 2000 published papers that was found, 1700 publications were screened out owing to duplicate data. In addition, 60 publications were eliminated because they did not have appropriate information for this current study, and 200 papers were eliminated because of erroneous information. For being overly shallow, 29 publications were ignored. In the end, this study included 11 (eleven) publications. Conclusion: Worldwide, there is a high prevalence of female adolescents using intravenous psychoactive drugs. The causes include feelings of helplessness following family separation, poor academic performance, a physical environment, prior substance use, recreational alternatives, socialisation issues, and inadequate organisational support. Cardiovascular illness, psychological diseases like anxiety, dependency, mood, and psychosis disorders, as well as various Hormonal Contraceptives, are all consequences of intravenous psychoactive drug use among female teenagers (HC). According to this study, more Motivational Enhancement Therapy (MET), family counselling, and cognitive-behavioural therapy should be used to free female adolescents from the shackles of intravenous psychoactive substance use.

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Section: Introductionmentioning

confidence: 99%

A Systematic Review of Intravenous Psychoactive Drug Use among Adolescent Females

AK¹,

Metu²,

PC³

2023

J Biomed Res Environ Sci

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The synergy of structural and functional connectivity

Calamante

2023

Connectome Analysis

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Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats

Hsu,

Cerri,

Lee

et al. 2024

J. Neurosci.

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While functional brain imaging studies in humans suggest that chronic cocaine use alters functional connectivity within and between key large-scale brain networks, including the default mode network (DMN), the salience network (SN), and the central executive network (CEN), cross-sectional studies in humans are challenging to obtain brain functional connectivity prior to cocaine use. Such information is critical to reveal the relationship between individual's brain functional connectivity and the subsequent development of cocaine dependence and brain changes during abstinence. Here, we performed a longitudinal study examining functional magnetic resonance imaging (fMRI) data in male rats (n = 7), acquired before cocaine self-administration (baseline), on 1 day of abstinence following 10 days of cocaine self-administration, and again after 30 days of experimenter-imposed abstinence. Using repeated measures analysis of variance (ANOVA) with network-based statistics (NBS), significant connectivity changes were found between anterior insular cortex (AI) of the SN, retrosplenial cortex (RSC) of the DMN, somatosensory cortex, and caudate putamen (CPu), with AI-RSC functional connectivity showing the most robust changes between baseline and 1 day of abstinence. Additionally, the level of escalated cocaine intake is associated with AI–RSC and AI–CPu functional connectivity changes between 1 day and 30 days of abstinence; further, the subjects’ AI–RSC functional connectivity prior to cocaine intake is a significant moderator for the AI-RSC changes during abstinence. These results provide novel insights into the roles of AI-RSC functional connectivity before and after cocaine intake and suggest this circuit to be a potential target to modulate large-scale network and associated behavioral changes in cocaine use disorders.Significance StatementThis study examines the impact of chronic cocaine self-administration on brain network-level interactions involving the default mode network (DMN; retro-splenial cortex, RSC), salience network (SN; anterior insular, AI), and caudate putamen (CPu). These brain regions have been associated with self-referential functions, emotion, memory, and coordination between internal and external stimuli and align with the "triple network model" of psychopathology and addiction. By identifying relationships between the escalated cocaine self-administration and the changes of functional connectivity across longitudinal measures, this study contributes to the future development of circuit-based treatment strategies and suggests AI and RSC connectivity to be an imaging circuit marker for cocaine use disorders.

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Valuation system connectivity is correlated with poly-drug use in young adults

Cited by 3 publications

References 75 publications

A Systematic Review of Intravenous Psychoactive Drug Use among Adolescent Females

A Systematic Review of Intravenous Psychoactive Drug Use among Adolescent Females

The synergy of structural and functional connectivity

Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats

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