Valsartan ingestions among adults reported to Texas poison control centers, 2000 to 2005

Abstract

Introduction: Little data exist on potentially adverse valsartan ingestions reported to poison control centers. Methods: Using adult ingestions of valsartan reported to Texas poison control centers during 2000-2005, I determined the proportion of cases involving serious outcomes for selected variables and evaluated for statistical significance by calculating the rate ratio (RR) and 95% confidence interval (CI).Results: Thirteen (7%) of 185 total cases involved serious outcomes. Serious outcomes were significantly more likely to occur with a maximum dose Ͼ320 mg (RR 9.06, CI 1.30-100.14) or Ͼ4 tablets (RR 9.00, CI 2.07-39.11) or where the circumstances of the exposures involved self-harm or malicious intent (RR 17.28,.Conclusions: The severity of the medical outcome associated with adult valsartan ingestions depended on the dose and the circumstances of the ingestion. Such information is useful for creating triage guidelines for the management of adult valsartan ingestions.

Simultaneous Use of Intravenous Lipid Emulsion and Plasma Exchange Therapies in Multiple Drug Toxicity

“…Valsartan is an angiotensin receptor blocker used for the treatment of hypertension. Although its toxic dose is not known, hemodialysis does not provide much benefit in the case of an overdose [ 4 ]. Aripiprazole is highly bound to plasma proteins and it is metabolized in the liver.…”

Postmortem blood concentrations of sartans measured by liquid chromatography-tandem mass spectrometry

“…This case indicated that fetal renal impairment due to olmesartan medoxomil may be reversible [5]. A study of 185 adult referrals to poison control centers for valsartan ingestion, reported that only 7 % of the cases were judged to be serious [6]. The manifestations of the poisonings included dizziness, drowsiness, bradycardia/tachycardia and hypotension/ hypertension [6].…”

“…A study of 185 adult referrals to poison control centers for valsartan ingestion, reported that only 7 % of the cases were judged to be serious [6]. The manifestations of the poisonings included dizziness, drowsiness, bradycardia/tachycardia and hypotension/ hypertension [6]. Two overdose cases have also been reported.…”