Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers
Aleksandra Georgievski,
Pierre-Simon Bellaye,
Benjamin Tournier
et al.
Abstract:We created valrubicin-loaded immunoliposomes (Val-ILs) using the antitumor prodrug valrubicin, a hydrophobic analog of daunorubicin. Being lipophilic, valrubicin readily incorporated Val-lLs that were loaded with specific antibodies. Val-ILs injected intravenously rapidly reached the bone marrow and spleen, indicating their potential to effectively target cancer cells in these areas. Following the transplantation of human pediatric B-cell acute lymphoblastic leukemia (B-ALL), T-cell acute lymphoblastic leukemi… Show more
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