Valproic acid promotes the neuronal differentiation of spiral ganglion neural stem cells with robust axonal growth

Moon, Byoung-San; Lu, Wange; Park, Hong Ju

doi:10.1016/j.bbrc.2018.08.032

Cited by 16 publications

(11 citation statements)

References 40 publications

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“…5 E). In line with this, single treatment with VA has been reported to increase neurite length in human neuroblastoma cells [ 97 ], in mouse embryonic NSCs [ 98 ], in primary rat cortical neurons [ 99 ], in spiral ganglion NSCs [ 100 ], and in a murine Alzheimer's disease model [ 101 ]. Prenatal exposure to VA has been shown to increase the risk of ASD-related features, including neural tube developmental defects and imbalance of excitatory/inhibitory synapse [ [102] , [103] , [104] ].…”

Section: Discussionmentioning

confidence: 88%

Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures

Herrmann

Carpi

Gyves

et al. 2021

Reproductive Toxicology

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Highlights Mixtures of similar MoA chemicals increased BDNF levels and neurite outgrowth. Mixtures of similar MoA chemicals decreased synapse formation and electrical activity. Synergistic effects on synaptogenesis features was predicted by mathematical modelling. Some of the DNT effects observed in hiPSC-neurons/astrocytes recapitulate ASD features. In vitro assays combined with mathematical modelling enable DNT testing of chemical mixtures.

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Section: Discussionmentioning

confidence: 88%

Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures

Herrmann

Carpi

Gyves

et al. 2021

Reproductive Toxicology

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“…In fact, the roles of the radial glia in Parkinson’s disease (Singh et al, 2018) and Alzheimer’s disease (Diniz et al, 2019) have been well studied. Although it is suggested that valproate (VPA) can treat migraine by activating the wnt/beta-catenin pathway, which regulates cell regeneration and differentiation, especially glial cell differentiation and regeneration (Wang et al, 2010b; Moon et al, 2018), the specific regulation mechanism is not clear. Thus, further studies are required to explore the relationship between radial glia cells and migraine.…”

Section: Discussionmentioning

confidence: 99%

Identifying Common Genes, Cell Types and Brain Regions Between Diseases of the Nervous System

Fan

Wang

et al. 2019

Front. Genet.

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Background: Diseases of the nervous system are widely considered to be caused by genetic mutations, and they have been shown to share pathogenic genes. Discovering the shared mechanisms of these diseases is useful for designing common treatments. Method: In this study, by reviewing 518 articles published after 2007 on 20 diseases of the nervous system, we compiled data on 1607 mutations occurring in 365 genes, totals that are 1.9 and 3.2 times larger than those collected in the Clinvar database, respectively. A combination with the Clinvar data gives 2434 pathogenic mutations and 424 genes. Using this information, we measured the genetic similarities between the diseases according to the number of genes causing two diseases simultaneously. Further detection was carried out on the similarity between diseases in terms of cell types. Disease-related cell types were defined as those with disease-related gene enrichment among the marker genes of cells, as ascertained by analyzing single-cell sequencing data. Enrichment profiles of the disease-related genes over 25 cell types were constructed. The disease similarity in terms of cell types was obtained by calculating the distances between the enrichment profiles of these genes. The same strategy was applied to measure the disease similarity in terms of brain regions by analyzing the gene expression data from 10 brain regions. Results: The disease similarity was first measured in terms of genes. The result indicated that the proportions of overlapped genes between diseases were significantly correlated to the DMN scores (phenotypic similarity), with a Pearson correlation coefficient of 0.40 and P-value = 6.0×10-3. The disease similarity analysis for cell types identified that the distances between enrichment profiles of the disease-related genes were negatively correlated to the DMN scores, with Spearman correlation coefficient = -0.26 (P-value = 1.5 × 10-2). However, the brain region enrichment profile distances of the disease-related genes were not significantly correlated with the DMN score. Besides the similarity of diseases, this study identified novel relationships between diseases and cell types. Conclusion: We manually constructed the most comprehensive dataset to date for genes with mutations related to 20 nervous system diseases. By using this dataset, the similarities between diseases in terms of genes and cell types were found to be significantly correlated to their phenotypic similarity. However, the disease similarities in terms of brain regions were not significantly correlated with the phenotypic similarities. Thus, the phenotypic similarity between the diseases is more likely to be caused by dysfunctions of the same genes or the same types of neurons rather than the same brain regions. The data are collected into the database NeurodisM, which is available at .

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“…Having shown that treatment with GFs alone, which could enhance precursor proliferation, was insufficient to facilitate eventual regeneration of SGNs, we then treated the injured mice with a combination of GFs and VPA. VPA, an HDAC inhibitor that is used as an antiepileptic drug, is known to induce neuronal differentiation of proliferating cells and to promote neuronal survival (21)(22)(23)(24)33). To examine whether VPA improves neuronal differentiation and survival in the ouabain-damaged SG, we treated the injured mice with GFs on day 3 and injected VPA intraperitoneally from day 7, when proliferating cells were shown to have increased significantly (Figure 3C), for 1 week, then sacrificed them on day 28 after injury (Figure 5A).…”

Section: Resultsmentioning

confidence: 99%

Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration

Wakizono¹,

Nakashima²,

Yasui³

et al. 2021

JCI Insight

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Valproic acid promotes the neuronal differentiation of spiral ganglion neural stem cells with robust axonal growth

Cited by 16 publications

References 40 publications

Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures

Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures

Identifying Common Genes, Cell Types and Brain Regions Between Diseases of the Nervous System

Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration

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