Valproic acid induced acute liver injury resulting in hepatic encephalopathy- a case report and literature review

Gayam, Vijay; Mandal, Amrendra; Khalid, Mazin; Shrestha, Binav; Garlapati, Pavani; Khalid, Mowyad

doi:10.1080/20009666.2018.1514933

Cited by 31 publications

(19 citation statements)

References 28 publications

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“…Our data showed that GABA transaminase is not only highly enriched in brain but also in the liver with the highest abundance level. The unknown liver toxicity could be caused by the inhibition of GABA transaminase in liver (47).…”

Section: Proteome Genetic Diseases and Drug Targetsmentioning

confidence: 99%

A Quantitative Proteome Map of the Human Body

Jiang

Wang

Lin

et al. 2019

Preprint

109

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Quantitative proteome study of 32 human tissues and integrated analysis with transcriptome data revealed that understanding protein levels could provide in-depth knowledge to post transcriptional or translational regulations, human metabolism, secretome, and diseases. AbstractDetermining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from 12,627 genes across 32 normal human tissue types prepared by the GTEx project. Known and new tissue specific or enriched proteins (5,499) were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode highly tissue specific proteins. Discordance in the sites of RNA expression and protein detection also revealed potential sites of synthesis and action of protein signaling molecules. Overall, these results provide an extraordinary resource, and demonstrate that understanding protein levels can provide insights into metabolism, regulation, secretome, and human diseases.

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Section: Proteome Genetic Diseases and Drug Targetsmentioning

confidence: 99%

A Quantitative Proteome Map of the Human Body

Jiang

Wang

Lin

et al. 2019

Preprint

109

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“…The toxicity of valproic acid is closely linked to impaired liver function but remains complex [ 26 , 27 ]. Fan and colleagues reported on a small sample of COVID-19 patients who one-third of patients presented abnormal liver function [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Toxicity of psychotropic drugs in patients with COVID-19: A systematic review

Sabé¹,

Dorsaz²,

Huguelet³

et al. 2021

General Hospital Psychiatry

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Objective Due to the global spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), guidance for the use of psychotropic drugs in this context is necessary. We aimed to review clinical evidence regarding the potential toxicity of psychiatric medications in the context of SARS-CoV-2 infection. Methods A systematic search for all types of empirical studies and reviews in a broad set of electronic databases and trial registries was conducted up to the 15th of August 2020. Results We identified 3 case series and 4 single-case reports on the occurrence of toxicity induced by various psychotropic drugs (lithium, n = 2; clozapine, n = 5; risperidone n = 2; haloperidol n = 1; duloxetine, n = 1). In addition, we provide a new case report on the possible precipitation of valproic acid-induced hyperammonemic encephalopathy. In most cases, SARS-CoV-2 infection may have precipitated drug toxicity/side effects. The management of toxicity did not diverge from the usually applied principles in the absence of infection. Conclusions Due to the limited available evidence, it is currently not possible to derive evidence-based recommendations for the use of psychotropic drugs in the context of SARS-CoV-2 infection. Nevertheless, we provide some guidance based on the reviewed literature. At the current state of knowledge, there is no contraindication for any psychotropic drug. Caution is warranted regarding the dosing and, in particular, the monitoring of clozapine, lithium and valproate.

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“…12 Valproate is commonly used in the management of epileptic seizures. 13 Documented side effects of valproate include obesity, insulin resistance, metabolic disorder, and severe forms of hepatotoxicity. Elevated transaminase levels have been reported in up to 5% to 10% of patients taking valproate.…”

Section: Introductionmentioning

confidence: 99%

“…Elevated transaminase levels have been reported in up to 5% to 10% of patients taking valproate. 13,14 There is a need to routinely monitor liver function and full blood count in patients receiving AED therapy. This study set out to determine the pattern of utilization of AEDs, extent of documentation of adverse drug reactions associated with AEDs, the extent of monitoring of the hematologic effects of carbamazepine, as well as the extent of monitoring of the hepatic effects of valproate in patients with epilepsy receiving treatment with these agents in 2 selected neurologic clinics in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria

Eshiet

Ubaka

Ukwe

2020

J Cent Nerv Syst Dis

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Background: Carbamazepine and valproate are widely used in the treatment of epileptic seizures. However, these agents exhibit certain adverse effects including hematopoietic disorders (carbamazepine) and severe hepatotoxicity (valproate). Purpose: To determine the extent of monitoring of the hematologic effects of carbamazepine as well as the extent of monitoring of the hepatic effects of valproate in patients with epilepsy receiving treatment with these agents. Method: A cross-sectional antiepileptic drug use study using case notes of patients with epilepsy managed at the neurologic clinics of 2 tertiary medical facilities in Nigeria between January and December 2017. Results: Carbamazepine was the most frequently prescribed antiepileptic drug (48.24%), followed by valproate (29.34%) and levetiracetam (9.24%). Pretreatment monitoring of hematologic effect was carried out in only 61.11% of patients placed on carbamazepine therapy while follow-up monitoring was done in 3.7% of these patients. Also, in patients placed on valproate therapy, pretreatment and follow-up monitoring of the hepatic effect was done in only 33.71% and 19.0% of the patients, respectively. Conclusions: The extent of monitoring of the hematologic effects of carbamazepine, as well as the hepatic effects of valproate in the cohort studied, is poor.

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Valproic acid induced acute liver injury resulting in hepatic encephalopathy- a case report and literature review

Cited by 31 publications

References 28 publications

A Quantitative Proteome Map of the Human Body

A Quantitative Proteome Map of the Human Body

Toxicity of psychotropic drugs in patients with COVID-19: A systematic review

Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria

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