Valproate Induced Hypertensive Urgency

Sivananthan, Mauran; Mohiuddin, Sarah

doi:10.1155/2016/1458548

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…With mood stabilizers like lithium, animal models demonstrated antihypertensive effects [122] through its similar renal effects in humans [123]. Valproate, on the other hand, has been associated with hypertension in 1–5% of patients, [124] including a case report of a valproate-associated hypertensive urgency in an 8 year old child which resolved with discontinuation of the medication [125].…”

Section: Introductionmentioning

confidence: 99%

Cardiometabolic effects of psychotropic medications

Abosi

Lopes

Schmitz

et al. 2018

Hormone Molecular Biology and Clinical Investigation

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Abstract:Background: Many psychiatric disorders including schizophrenia, bipolar disorder and major depression convey an excess burden of cardiovascular morbidity and mortality. The medications used to treat these conditions may further adversely affect cardiovascular risk and exacerbate health disparities for vulnerable populations. There is a clinical need to appreciate the cardiometabolic adverse effects of psychotropic medications. Methods: This paper reviews the most relevant cardiometabolic effects of psychotropic medications, organized around the components of metabolic syndrome. When known, the molecular and physiological mechanisms underlying any adverse cardiometabolic effects are detailed. Results: Many commonly used psychotropic medications, particularly antipsychotics, mood stabilizers and some antidepressants, have been independently associated with cardiometabolic risk factors such as insulin resistance, obesity and dyslipidemia. Stimulants, antidepressants that inhibit reuptake of norepinephrine, some antipsychotics and valproic acid derivatives may also increase blood pressure. Conclusion: Understanding, assessing and subsequently managing cardiometabolic complications of psychotropic medications are important to mitigate the excess cardiovascular morbidity and mortality in the clinical populations prescribed psychotropic medications. There is considerable variability in risk between medications and individuals. Timely management of iatrogenic cardiometabolic effects is critical.

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Section: Introductionmentioning

confidence: 99%

Cardiometabolic effects of psychotropic medications

Abosi

Lopes

Schmitz

et al. 2018

Hormone Molecular Biology and Clinical Investigation

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“…52 Mixed responses in BP are reported in human patients after valproate administration. 53,54 The effect of other HDACis, such as vorinostat, sodium butyrate, and entinostat, on hypertensive rodent models is discussed in the Supplemental Material.…”

Section: Reviewmentioning

confidence: 99%

Histone Modifications and Their Contributions to Hypertension

Ray,

Stelloh,

Liu

et al. 2024

Hypertension

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Essential hypertension, a multifaceted disorder, is a worldwide health problem. A complex network of genetic, epigenetic, physiological, and environmental components regulates blood pressure (BP), and any dysregulation of this network may result in hypertension. Growing evidence suggests a role for epigenetic factors in BP regulation. Any alterations in the expression or functions of these epigenetic regulators may dysregulate various determinants of BP, thereby promoting the development of hypertension. Histone posttranslational modifications are critical epigenetic regulators that have been implicated in hypertension. Several studies have demonstrated a clear association between the increased expression of some histone-modifying enzymes, especially HDACs (histone deacetylases), and hypertension. In addition, treatment with HDAC inhibitors lowers BP in hypertensive animal models, providing an excellent opportunity to design new drugs to treat hypertension. In this review, we discuss the potential contribution of different histone modifications to the regulation of BP.

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“…Valproic acid has been shown to lower blood pressure in spontaneusly hypertensive rats Cardinale et al [13] and prevented high fat diet-induced hypertension (Choi, et al [14]). On the other hand, it has been reported that one of the side effects of taking valproate is increased blood pressure and high heart rate (Sivananthan, et al [15]). Due to the contradictory results of the effect of sodium valproate (VPA) on blood pressure; In this study, the role of VPA on the hypertension of epileptic rats was investigated by the kindling method (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

"The Effect of Sodium Valproate on Cardiovascular Responses in Pentylenetetrazol Kindling Model of Epilepsy"

Mohammadzadeh

2022

BJSTR

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Valproate Induced Hypertensive Urgency

Cited by 6 publications

References 7 publications

Cardiometabolic effects of psychotropic medications

Cardiometabolic effects of psychotropic medications

Histone Modifications and Their Contributions to Hypertension

"The Effect of Sodium Valproate on Cardiovascular Responses in Pentylenetetrazol Kindling Model of Epilepsy"

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