Valproate in the treatment of PTSD: systematic review and meta analysis

Adamou, Marios; Puchalska, Sylvia; Plummer, William P; Hale, Anthony S.

doi:10.1185/030079907x188116

Cited by 42 publications

(29 citation statements)

References 28 publications

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“…A systematic review of valproate in the treatment of post-traumatic stress disorder [65] identified no double-blind studies although one single-blinded study and four open-label studies were found. These provide some evidence that valproate improved symptoms of post-traumatic stress disorder, in particular reducing symptoms of hyperarousal such as irritability and anger outbursts.…”

Section: Miscellaneous Conditionsmentioning

confidence: 99%

A review of valproate in psychiatric practice

Haddad

Das

Ashfaq

et al. 2009

Expert Opinion on Drug Metabolism & Toxicology

117

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Valproate (2-propylpentanoate) is available as valproic acid, sodium valproate and semisodium valproate. It has actions on dopamine, GABA and glutamate neurotransmission and intracellular signaling. Its main psychiatric use is to treat bipolar disorder. It has been used in other psychiatric disorders, including schizophrenia and borderline personality disorder, but data are insufficient to recommend this. In acute mania, valproate monotherapy has similar efficacy to antipsychotic drugs and lithium whereas the combination of valproate and an antipsychotic is more effective than either drug alone. In maintenance treatment of bipolar disorder, valproate monotherapy has comparable efficacy to olanzapine although placebo-controlled evidence is limited. Maintenance treatment with valproate and quetiapine or olanzapine is more efficacious than valproate alone when an acute episode responds to the combination. Common adverse effects of valproate include weight gain, gastrointestinal symptoms, sedation, tremor and mild elevation of hepatic enzymes. Serious hepatic toxicity is rare in adults. Many adverse effects are dose related and resolve with dose reduction. Valproate is teratogenic and specifically associated with neural tube defect. Preliminary evidence has linked in utero exposure to decreased verbal intelligence in the offspring. These effects, plus a probable increased risk of polycystic ovary syndrome, limit valproate's use in women of childbearing potential.

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Section: Miscellaneous Conditionsmentioning

confidence: 99%

A review of valproate in psychiatric practice

Haddad

Das

Ashfaq

et al. 2009

Expert Opinion on Drug Metabolism & Toxicology

117

View full text Add to dashboard Cite

show abstract

“…Valproic acid increases the amount of GABA, a neurotransmitter (Adamou, Puchalska, Plummer, & Hale, 2007) and enhances the inhibition of gamma-aminobutyric acid. Through these mechanisms, it is hypothesized that valproic acid reduces intrusion and hyperarousal symptoms associated with PTSD (Otte, Wiedemann, Yassouridis, & Kellner, 2004).…”

Section: Valproic Acid (Valproate and Divalproex)mentioning

confidence: 99%

A Review of Interventions for Treatment-Resistant Posttraumatic Stress Disorder

Katz¹,

Stein²,

Richardson³

et al. 2011

Different Views of Anxiety Disorders

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“…La adición de olanzapina y risperidona podría ser útil, especialmente en los síntomas de intrusión 28 . El ácido valproico también podría ser útil 33 . En cualquier caso, estos y otros tratamientos experimentales, como la realidad virtual 30 , deberían ser indicados por exTabla 4.…”

Section: Nivel V Manejo Psiquiátrico Por Expertosunclassified