Valproate for schizophrenia: ambrosia?

COVID delirium—psychopharmacological tips

“…Valproate confers neuroprotection as a bonanza. 5 It has been shown in COVID delirium-catatonia composite presentation is at times difficult to brush out, and given the differential response to antipsychotics-benzodiazepines, some authors have suggested deploying amantadine. Amantadine has dopaminomimetic, weak anticholinergic and antiglutamate actions that can be helpful in these complex clinical scenarios.…”

“…Since multifocal myoclonus and seizures are fairly commonplace in COVID deliria, use of broad-spectrum antiepileptic drugs like valproate can be justified to target agitation as well. Valproate confers neuroprotection as a bonanza 5 …”