Valproate and lithium: Old drugs for new pharmacological approaches in brain tumors?

Natale, Gianfranco; Fini, Elisabetta; Calabrò, Pasquale Fabio; Carli, Marco De; Scarselli, Marco; Bocci, Guido

doi:10.1016/j.canlet.2023.216125

Cited by 8 publications

(7 citation statements)

References 101 publications

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“…GSK3 is the central enzyme inhibited by Li+ that results in some inhibition of malignant growth [15,79,80]. As briefly presented in section 2.B.…”

Section: Lithiummentioning

confidence: 99%

SALIQ in Rhabdomyosarcoma: A Repurposed Multidrug Regimen to Augment Standard Treatments by Adding Simvastatin, All Trans Retinoic Acid, Lithium, Itraconazole, and Quercetin

Kast,

Zaghloul,

Sardi

et al. 2023

Preprint

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Rhabdomyosarcoma is a cancer arising from arrested myogenic differentiation, seen mainly in children or adolescents. Metastatic rhabdomyosarcoma is often fatal even with aggressive cytotoxic chemotherapies, surgery, and irradiation. SALIQ is an acronym for a multidrug augmentation regimen designed as an adjunct to current rhabdomyosarcoma chemotherapies. SALIQ uses five common non-oncology drugs, repurposed from general medicine use, to promote malignant clone maturation and inhibit rhabdomyosarcoma growth. The five drugs are: the cholesterol lowering drug simvastatin, the acne medicine tretinoin (ATRA), the psychiatric drug lithium carbonate, the antifungal drug itraconazole, and the food supplement quercetin. All five drugs are in common use for non-cancer conditions, are cheap, have an eminently safe side effect profile, and all five have preclinical evidence and good rationale for inhibiting rhabdomyosarcoma growth.

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“…GSK3 is the central enzyme inhibited by Li+ that results in some inhibition of malignant growth [15,79,80]. As briefly presented in section 2.B.…”

Section: Lithiummentioning

confidence: 99%

SALIQ in Rhabdomyosarcoma: A Repurposed Multidrug Regimen to Augment Standard Treatments by Adding Simvastatin, All Trans Retinoic Acid, Lithium, Itraconazole, and Quercetin

Kast,

Zaghloul,

Sardi

et al. 2023

Preprint

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“…: mebendazole) and antiepileptic (ex. : valproate) drugs are potentially novel options for glioblastoma based on their ability to cross the blood–brain barrier [ 13 , 14 , 15 ]. However, there is greater evidence for the repurposing of antidiabetic and antihypertensive drugs [ 16 , 17 ], given their efficacy in chronic metabolic diseases (diabetes and cardiovascular disease), because (1) these diseases are highly prevalent and their treatments well-studied, with an increased amount of knowledge regarding their use and potential benefit; (2) there are metabolic links and shared risk factors between these diseases and cancer; and (3) drugs that can be administered chronically are normally well-tolerated [ 18 ].…”

Section: Drug Repurposing In Cancermentioning

confidence: 99%

Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer

De Sousa-Coelho,

Fraqueza,

Aureliano

2023

Pharmaceuticals

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Repurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes vanadium a suitable metal to complex with therapeutic drugs, potentially improving their efficacy in cancer treatment. In this review, covering the last 25 years of research in the field, we identified non-oncology-approved drugs suitable as ligands to obtain different vanadium complexes. Metformin-decavanadate, vanadium-bisphosphonates, vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs, and cetirizine and imidazole-based oxidovanadium(IV) complexes, each has a parent drug known to have different medicinal properties and therapeutic indications, and all showed potential as novel anticancer treatments. Nevertheless, the precise mechanisms of action for these vanadium compounds against cancer are still not fully understood.

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“…3–5 On the other hand, lithium-based compounds have been used more widely in clinical applications. 6–8 They are used in a common treatment for psychosis 9,10 and bipolar disorders, 11,12 skin diseases, 13 and Alzheimer's disease. 14,15…”

Section: Introduction To Photochromic Compounds and Fluorescent Sensorsmentioning

confidence: 99%

“…[3][4][5] On the other hand, lithium-based compounds have been used more widely in clinical applications. [6][7][8] They are used in a common treatment for psychosis 9,10 and bipolar disorders, 11,12 skin diseases, 13 and Alzheimer's disease. 14,15 Fatemeh Javanbakht Fatemeh Javanbakht received her BSc degree in Polymer Engineering from Tabriz Payame Noor University in 2016.…”

Section: Introduction To Photochromic Compounds and Fluorescent Sensorsmentioning

confidence: 99%

A review on photochemical sensors for lithium ion detection: relationship between the structure and performance

Javanbakht,

Najafi,

Jalili

et al. 2023

J. Mater. Chem. A

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Valproate and lithium: Old drugs for new pharmacological approaches in brain tumors?

Cited by 8 publications

References 101 publications

SALIQ in Rhabdomyosarcoma: A Repurposed Multidrug Regimen to Augment Standard Treatments by Adding Simvastatin, All Trans Retinoic Acid, Lithium, Itraconazole, and Quercetin

SALIQ in Rhabdomyosarcoma: A Repurposed Multidrug Regimen to Augment Standard Treatments by Adding Simvastatin, All Trans Retinoic Acid, Lithium, Itraconazole, and Quercetin

Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer

A review on photochemical sensors for lithium ion detection: relationship between the structure and performance

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