Valorizing Constituents of Cashew Nut Shell Liquid toward the Sustainable Development of New Drugs against Chagas Disease

Lemes, Laís Flávia Nunes; Magoulas, George E.; Oliveira, Andressa Souza de; Barrias, Emile; Nascente, Luciana de Camargo; Granado, Renato; Silva, Sara Teixeira de Macedo; Assimomytis, Nikos; Souza, Wanderley de; Bolognesi, María Laura; Romeiro, Luiz Antônio Soares; Calogeropoulou, Theodora

doi:10.1021/acsinfecdis.3c00076

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…In turn, the latter ones were coupled with the choline headgroup in the presence of 1-(mesitylenesulfonyl)-3-nitro-1,2,4-triazolide (MSNT) as the condensing agent. The obtained derivatives were active on the epimastigote, trypomastigote, and amastigote life stages of T. cruzi , with 36 exhibiting a remarkable submicromolar activity ( 36 , IC 50 = 0.17 μM) against the clinically relevant, intracellular amastigote form of T. cruzi …”

Section: The 12 Principles Of Green Chemistry and Drug Development Fo...mentioning

confidence: 99%

Harnessing the 12 Green Chemistry Principles for Sustainable Antiparasitic Drugs: Toward the One Health Approach

Martinengo,

Diamanti,

Uliassi

et al. 2024

ACS Infect. Dis.

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Antiparasitic drug development stands as a critical endeavor in combating infectious diseases which, by affecting the well-being of humans, animals, and the environment, pose significant global health challenges. In a scenario where conventional pharmacological interventions have proven inadequate, the One Health approach, which emphasizes interdisciplinary collaboration and holistic solutions, emerges as a vital strategy. By advocating for the integration of One Health principles into the R&D pharmaceutical pipeline, this Perspective promotes green chemistry methodologies to foster the development of environmentally friendly antiparasitic drugs for both human and animal health. Moreover, it highlights the urgent need to address vector-borne parasitic diseases (VBPDs) within the context of One Health-driven sustainable development, underscoring the pivotal role of medicinal chemists in driving transformative change. Aligned with the Sustainable Development Goals (SDGs) and the European Green Deal, this Perspective explores the application of the 12 Principles of Green Chemistry as a systematic framework to guide drug discovery and production efforts in the context of VBPD. Through interdisciplinary collaboration and a constant commitment to sustainability, the field can overcome the challenges posed by VBPD while promoting global and environmental responsibility. Serving as a call to action, scientists are urged to integrate One Health concepts and green chemistry principles into routine drug development practices, thereby paving the way for a more sustainable R&D pharmaceutical pipeline for antiparasitic drugs.

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Section: The 12 Principles Of Green Chemistry and Drug Development Fo...mentioning

confidence: 99%

Harnessing the 12 Green Chemistry Principles for Sustainable Antiparasitic Drugs: Toward the One Health Approach

Martinengo,

Diamanti,

Uliassi

et al. 2024

ACS Infect. Dis.

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“…Cashew tree (Anacardium occidentale L.) is a tropical crop (native from Brazil) with multiple uses which can contribute to several food and industry sectors (Nyirenda et al 2021;Chen et al 2023;Nunes Lemes et al 2023). With around 1,095,000 tons of nuts produced in 2022 (www.fao.org/faostat/fr/#data/), cashew tree ranks third among the nut crops after almond (1,477,000 tons) and walnut (1,1556 tons).…”

Section: Introductionmentioning

confidence: 99%

Participatory identification of cashew (Anacardium occidentale L.) promising genetic resources in Ivory Coast

Yepié,

Koffi,

Akaffou

et al. 2023

Preprint

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Ivory Coast ranks first and third in the world in cashew nut production and processing, respectively. Despite this performance, the profitability of Ivorian cashew orchards remains low, due mainly to a lack of improved varieties and the use of inappropriate farming practices. To address this problem, farmer-participatory selection of promising trees was conducted for three consecutive years (2019–2021) in four administrative regions covering the main cashew production zones of the country. Investigations were carried out on 121 cashew trees using eight quality traits indicated by farmers, six yield components and two traits of industrial interest. High phenotypic variability was noted for most of the traits analyzed (coefficient of variation > 25% for 12/15 traits). A total of 42 trees was identified as promising trees. Considering the yield trait, 9, 22, and 11 trees were classified as good (15–20 kg nut/year), best (21–30 kg nut/year), and elite (> 30 kg nut/year), respectively. From the combined analysis of quality criteria, five trees (L45, A15, R22, J27, and H23) were proposed for local distribution to farmers. Five trees with good industrial qualities in addition to interesting yields (17.28–28.95 kg nut/year) have been proposed for cultivation for double purposes: A45 and G14 for nut and beverages; and A34, A41, F21, and L22 for nut and the cashew nut shell liquid. The trees G27, I11, l12, and G24 with high sugar contents (37.71–26.24 Brix) can be grown for beverages. Phenetic analysis showed only two distinct groups, suggesting a narrow genetic basis of cashew trees in Ivorian orchards. Additional studies and means for a better valorization of these genetic resources are suggested.

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Valorizing Constituents of Cashew Nut Shell Liquid toward the Sustainable Development of New Drugs against Chagas Disease

Cited by 2 publications

References 40 publications

Harnessing the 12 Green Chemistry Principles for Sustainable Antiparasitic Drugs: Toward the One Health Approach

Harnessing the 12 Green Chemistry Principles for Sustainable Antiparasitic Drugs: Toward the One Health Approach

Participatory identification of cashew (Anacardium occidentale L.) promising genetic resources in Ivory Coast

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