Valorization and identification of bioactive compounds of a spice Ammodaucus leucotrichus

Mouderas, Faiza; Lahfa, Farid; Mezouar, Dounia; Benahmed, Nor El Houda

doi:10.1007/s13596-019-00390-0

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…The seeds hydroalcoholic extract of A. leucotrichus yielded TPC and total flavonoid content values of 83.07 ± 0.37 mg GAE/g DW (w/w) and 67.53 ± 0.34 mg QE/g DW (w/w) respectively. Such values are higher than those obtained by Mouderas et al., 45.69 ± 0.4 mg GAE/g DW (w/w) and 18.94 ± 0.29 mg QE/g DW (w/w), respectively, for the aerial parts of such a spice [25]. Likewise, Halla et al.…”

Section: Resultsmentioning

confidence: 69%

Determination of the polyphenolic content of Ammodaucus leucotrichus Cosson and Durieu by liquid chromatography coupled with mass spectrometry and evaluation of the antioxidant and antiglycation properties

Selama

Cadi

Ramdan

et al. 2022

J of Separation Science

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Ammodaucus leucotrichus Cosson and Durieu, known as Sahara cumin, is a plant belonging to the Apiaceae family with a very strong smell of anise growing in the maritime sands in the countries of North Africa. The present work aims to study the polyphenolic profile of its seeds hydroalcoholic extract along with the determination of the antioxidant and antiglycation properties. The phytochemical screening revealed the presence of 16 compounds, out of which 15 have been detected in this extract for the first time. Luteolin-glucoside turned out to be the most abundant one (281.32 ± 0.34 mg/kg), followed by apigenin-hexoside (235.06 ± 0.29 mg/kg) and luteolin (202.41 ± 0.40 mg/kg). In terms of antioxidant activity, a half-maximal inhibitory concentration value as high as 0.39 ± 0.003 mg AAE/ml (w/v) was attained. Further, the antiglycation activity was determined to yield interesting results: at a concentration of 1.5 mg/ml, the extract showed an antiglycation activity (%I) of 61.86 compared to metformin as a positive control (%I = 84.01); on the other hand, increasing the concentration to 10 mg/ml,

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Section: Resultsmentioning

confidence: 69%

Determination of the polyphenolic content of Ammodaucus leucotrichus Cosson and Durieu by liquid chromatography coupled with mass spectrometry and evaluation of the antioxidant and antiglycation properties

Selama

Cadi

Ramdan

et al. 2022

J of Separation Science

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“…Algeria boasts a diverse collection of medicinal plants that are utilized by the local community and traditional healers to treat a variety of ailments (Mouderas et al, 2020) and it is one of the richest Arab countries with 3164 plant species (Benarba, 2016). The genus Achillea comprises many species known for their therapeutic benefits (Fahed et al, 2016;Sardrodi et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Alkaline DMSO superoxide and radical scavenging, cupric reducing antioxidant capacity (CUPRAC) and polyphenol contents of aqueous and methanol extract from Achilllea santolinoides L. aerial parts

Mehlous

Amira

Benchikh

et al. 2022

Turkish JAF Sci.Tech.

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The genus Achillea (Yarrow)is one of the most important medicinal plants. Nowadays, different medicinal functions of yarrow such as spasmolytic, choleretic, treatment of wounds and anti-inflammatory activities, make it as an important medicinal plant. The purpose of this study was to determine the antioxidant activity of aqueous (AAE) and methanol (AME) extracts from the plant Achillea santolinoides L. (A. santolinoides L.) aerial parts in vitro. Quantitative evaluation of polyphenols, flavonoids and tannins were determined using Folin-Ciocalteu reagent, aluminum chloride (AlCl3) and Bate Smith methods, respectively. Antioxidant activity was carried out using ABTS radical scavenging, alkaline DMSO superoxide radical scavenging and cupric reducing antioxidant capacity (CUPRAC). The obtained results showed that the highest content in total phenolic, flavonoids and tannins was found in the AME with values of 210.78±0.001 µg GAE/mg Dw, 21.18±0.025 µg QE/mg DW and198.73±0.014µg TAE/mg DW, respectively. For the in vitro antioxidant activity, AME had the strongest ABTS and DMSO alkaline radical scavenging activity (IC50= 6.74±0.16 µg/mL and 15.13±0.92 µg/mL, respectively) and the CUPRAC reducing with A0.50 of 76.56±2.35 µg/mL. The results of the present study confirm the use of the genus Achillea in the treatment of various diseases as a powerful antioxidant.

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“…Traditionally, it has been used in infusions or decoctions to treat cardiac disease [5], digestive problems [1,2,6] diabetes [7,8], aphrodisiac and tonic [6], in addition to being used as condiment and flavoring agent in tea and food seasonings [4]. AL fruit extract is reported to exhibit antioxidant [1,9], antibacterial [1,10], anti-inflammatory [10] and neuroprotective activities [11].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Pressurized Liquid Extraction and In Vitro Neuroprotective Evaluation of Ammodaucus leucotrichus. Untargeted Metabolomics Analysis by UHPLC-MS/MS

et al. 2021

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Ammodaucus leucotrichus is a spontaneous plant endemic of the North African region. An efficient selective pressurized liquid extraction (PLE) method was optimized to concentrate neuroprotective extracts from A. leucotrichus fruits. Green solvents were tested, namely ethanol and water, within a range of temperatures between 40 to 180 °C. Total carbohydrates and total phenolics were measured in extracts, as well as in vitro antioxidant capacity (DPPH radical scavenging), anticholinesterase (AChE) and anti-inflammatory (LOX) activities. Metabolite profiling was carried out by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry (UHPLC-ESI-q-TOF-MS/MS), identifying 94 compounds. Multivariate analysis was performed to correlate composition with bioactivity. A remarkable effect of the temperature using water was observed: the higher temperature, the higher extraction yield, the higher total phenolic content, as well as the higher total carbohydrates content. The water extract obtained at 180 °C, 10.34 MPa and 10 min showed meaningful anti-inflammatory (IC50LOX = 39.4 µg/mL) and neuroprotective activities (IC50AChE = 55.6 µg/mL). The Principal Components Analysis (PCA) and the cluster analysis correlated these activities with the presence of carbohydrates and phenolic compounds.

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Valorization and identification of bioactive compounds of a spice Ammodaucus leucotrichus

Cited by 6 publications

References 34 publications

Determination of the polyphenolic content of Ammodaucus leucotrichus Cosson and Durieu by liquid chromatography coupled with mass spectrometry and evaluation of the antioxidant and antiglycation properties

Determination of the polyphenolic content of Ammodaucus leucotrichus Cosson and Durieu by liquid chromatography coupled with mass spectrometry and evaluation of the antioxidant and antiglycation properties

Alkaline DMSO superoxide and radical scavenging, cupric reducing antioxidant capacity (CUPRAC) and polyphenol contents of aqueous and methanol extract from Achilllea santolinoides L. aerial parts

Optimization of Pressurized Liquid Extraction and In Vitro Neuroprotective Evaluation of Ammodaucus leucotrichus. Untargeted Metabolomics Analysis by UHPLC-MS/MS

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