Valores hematológicos e bioquímicos em tilápia do Nilo Oreochromis niloticus cultivada em sistema semi-intensivo

Bittencourt, Nilza de Lucas Rodrigues; Molinari, Lígia Maria; Scoaris, Denise de Oliveira; Pedroso, Raíssa Bocchi; Nakamura, Celso Vataru; Ueda-Nakamura, Tânia; Filho, Benício Alves de Abreu; Filho, Benetido Prado Dias

doi:10.4025/actascibiolsci.v25i2.2028

Cited by 8 publications

(1 citation statement)

References 8 publications

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“…The mean serum glucose level of the O. niloticus (74.00 ± 5.00 mg/dL) was concomitant with the values recorded by Bittencourt et al (2003). The 30 days of FFC-dosing increased the glucose levels signi cantly in all the treatment groups, indicating the FFC induced stress and altered carbohydrate metabolism (Sopinka et al 2016;Julinta et al 2019).…”

Section: Discussionmentioning

confidence: 65%

Effects of Extended Feeding of Florfenicol Coated Medicated Diets on the Safety, Serum Biomarkers and Blood Cells Morphology of Nile Tilapia Oreochromis Niloticus (L.) Juveniles

Bardhan¹,

Abraham²,

Singha³

et al. 2021

Preprint

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Tilapia is one of the most consumed farmed fish, which requires the use of antibiotics in certain phases of its production. This study assessed the safety of 30 days of oral florfenicol (FFC)-dosing at 0-10 times the therapeutic dose (1X: 10 mg/kg biomass/day) in Oreochromis niloticus juveniles. Behavioural changes, feed consumption, mortality and biomass were evaluated. Besides, the levels of serum glucose, calcium, chloride, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and blood cell morphology were determined at scheduled intervals. The 30 days of oral FFC-dosing caused 3.33% (1X) to 18.33% (10X) mortalities, reduced feed intake and biomass in a dose-dependent manner. The fish fed the therapeutic dose recorded 1.25 folds increase in biomass; while the control group recorded 1.45 folds increase in 30 days. No significant erythrocyte morphological alterations were observed in the 1X group compared to the control. However, marked morphological alterations like tear-shaped, spindle-shaped and degenerative erythrocytes in higher dosing groups indicated FFC cytotoxicity. All the serum biomarkers of O. niloticus increased significantly on day 10 and day 30 FFC-dosing in a dose-dependent manner, except for calcium and chloride, which reduced significantly during the dosing period. Within 2 weeks of suspension of FFC-dosing, the serum biomarker levels became normal except for alkaline phosphatase and creatinine. The recovery of biomass, feed intake, serum biomarker levels and erythrocyte morphological changes suggested that the FFC induced changes are reversible. This study has, thus, proclaimed the safety of FFC at the therapeutic dose in O. niloticus.

show abstract

Section: Discussionmentioning

confidence: 65%

Effects of Extended Feeding of Florfenicol Coated Medicated Diets on the Safety, Serum Biomarkers and Blood Cells Morphology of Nile Tilapia Oreochromis Niloticus (L.) Juveniles

Bardhan¹,

Abraham²,

Singha³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Short-term Exposure to Bisphenol A (BPA) as a Plastic Precursor: Hematological and Behavioral Effects on Oncorhynchus mykiss and Vimba vimba

Minaz

et al. 2022

Water Air Soil Pollut

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The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)

Bardhan

Abraham

Singha

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Tilapia is one of the most consumed farmed sh, which requires the use of antibiotics in certain phases of its production. This study assessed the safety of 30 days of oral orfenicol (FFC)-dosing at 0-10 times the therapeutic dose (1X: 10 mg/kg biomass/day) in Oreochromis niloticus juveniles. Behavioural changes, feed consumption, mortality and biomass were evaluated. Besides, the levels of serum glucose, calcium, chloride, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and blood cell morphology were determined at scheduled intervals. The 30 days of oral FFC-dosing caused 3.33% (1X) to 18.33% (10X) mortalities, reduced feed intake and biomass in a dosedependent manner. The sh fed the therapeutic dose recorded 1.25 folds increase in biomass; while the control group recorded 1.45 folds increase in 30 days. No signi cant erythrocyte morphological alterations were observed in the 1X group compared to the control. However, marked morphological alterations like tear-shaped, spindle-shaped and degenerative erythrocytes in higher dosing groups indicated FFC cytotoxicity. All the serum biomarkers of O. niloticus increased signi cantly on day 10 and day 30 FFC-dosing in a dose-dependent manner, except for calcium and chloride, which reduced signi cantly during the dosing period. Within 2 weeks of suspension of FFC-dosing, the serum biomarker levels became normal except for alkaline phosphatase and creatinine. The recovery of biomass, feed intake, serum biomarker levels and erythrocyte morphological changes suggested that the FFC induced changes are reversible. This study has, thus, proclaimed the safety of FFC at the therapeutic dose in O. niloticus.

show abstract

Valores hematológicos e bioquímicos em tilápia do Nilo Oreochromis niloticus cultivada em sistema semi-intensivo

Cited by 8 publications

References 8 publications

Effects of Extended Feeding of Florfenicol Coated Medicated Diets on the Safety, Serum Biomarkers and Blood Cells Morphology of Nile Tilapia Oreochromis Niloticus (L.) Juveniles

Effects of Extended Feeding of Florfenicol Coated Medicated Diets on the Safety, Serum Biomarkers and Blood Cells Morphology of Nile Tilapia Oreochromis Niloticus (L.) Juveniles

Short-term Exposure to Bisphenol A (BPA) as a Plastic Precursor: Hematological and Behavioral Effects on Oncorhynchus mykiss and Vimba vimba

The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)

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