Valoración cuantitativa del SPECT con FP-CIT. Importancia del área de referencia

Lozano, S.J. Ortega; Torres, M.D. Martínez del Valle; Moreno, E. Ramos; Viedma, S. Sanz; Raissouni, T. Amrani; Jiménez-Hoyuela, J.M.

doi:10.1016/j.remn.2010.03.006

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…A kappa index of 100% was obtained. The studies were also evaluated by semi-quantitative analysis, establishing uptake indices (after the sum of the six most representative axial images) between regions of interest (ROI) of an area of specific activity (striatal nuclei) and an area of non-specific activity (occipital cortex), obtaining the striatal/occipital index (S/O) [21]. This analysis can be performed independently of the gamma camera used and is highly reproducible.…”

Section: Spect Of Presynaptic Dopamine Transporters With [ 123 I]iofl...mentioning

confidence: 99%

Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy

Villena-Salinas

Ortega-Lozano

Amrani-Raissouni

et al. 2023

JCM

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Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder that has no curative treatment. Diagnosis is based on a set of criteria established by Gilman (1998 and 2008) and recently updated by Wenning (2022). We aim to determine the effectiveness of [123I]Ioflupane SPECT in MSA, especially at the initial clinical suspicion. Methods: A cross-sectional study of patients at the initial clinical suspicion of MSA, referred for [123I]Ioflupane SPECT. Results: Overall, 139 patients (68 men, 71 women) were included, 104 being MSA-probable and 35 MSA-possible. MRI was normal in 89.2%, while SPECT was positive in 78.45%. SPECT showed high sensitivity (82.46%) and positive predictive value (86.24), reaching maximum sensitivity in MSA-P (97.26%). Significant differences were found when relating both SPECT assessments in the healthy–sick and inconclusive–sick groups. We also found an association when relating SPECT to the subtype (MSA-C or MSA-P), as well as to the presence of parkinsonian symptoms. Lateralization of striatal involvement was detected (left side). Conclusions: [123I]Ioflupane SPECT is a useful and reliable tool for diagnosing MSA, with good effectiveness and accuracy. Qualitative assessment shows a clear superiority when distinguishing between the healthy–sick categories, as well as between the parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes at initial clinical suspicion.

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Section: Spect Of Presynaptic Dopamine Transporters With [ 123 I]iofl...mentioning

confidence: 99%

Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy

Villena-Salinas

Ortega-Lozano

Amrani-Raissouni

et al. 2023

JCM

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“…34 The confidence bounds are estimated by vertical averaging 35 throughout the resampling cross validations, and the AUC is estimated by trapezoidal approximation. We used two existing methods in the literature as a reference: the semiquantitative method proposed by Ortega-Lozano et al 12 (OL) and the automated method proposed by Towey et al 20 (TBN). The former is based on a semiquantitative analysis of manually selected regions to estimate the binding ratios [we have reported in Table I the most compelling results, obtained using the striatum/occipital (E/O) index and the same database (prevalence 0.48)].…”

Section: Iid Receiver Operator Characteristic Analysismentioning

confidence: 99%

“…Standard analyses of DAT SPECT imaging studies are performed by visual inspection using a predefined rating, [7][8][9][10] or the analysis of regions of interest (ROI). 11,12 In the latter, semiquantitative parameters are proposed in order to index absolute differences between specific/nonspecific uptake in the tomographic examinations with [ 123 I]FP-CIT, minimizing the possible sources of error that may arise due to the exclusive use of visual evaluation. 5 Semiquantitative parameters are measures of the activity in the relevant brain structures, that are usually obtained by calculable ratios between the activity of manually-defined ROIs.…”

Section: Introductionmentioning

confidence: 99%

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Automatic assistance to Parkinsonˈs disease diagnosis in DaTSCAN SPECT imaging

et al. 2012

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“…The results were evaluated qualitatively with a visual analysis and quantitatively by using predefined Regions of Interest (ROIs) to obtain Striatum/Occipital indices for each striatal nucleus (right S/O and left S/O) and globally (global S/O), the latter being the arithmetic mean of both [17]. The reference area of non-specific uptake was the occipital lobe [18].…”

Section: Methodsmentioning

confidence: 99%

Follow-Up Findings in Multiple System Atrophy from [123I]Ioflupane Single-Photon Emission Computed Tomography (SPECT): A Prospective Study

Villena-Salinas,

Ortega-Lozano,

Amrani-Raissouni

et al. 2023

Biomedicines

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Background: Multiple system atrophy (MSA) is subdivided into two types: MSA-P (parkinsonian) and MSA-C (cerebellar). Brain SPECT allows for the detection of nigrostriatal involvement, even in the early stages. To date, the scientific literature does not show a consensus on how to follow-up MSA, especially MSA-C. Our aim was to analyze the diagnostic effectiveness of repeat [123I]Ioflupane SPECT for the follow-up of MSA. Methods: A longitudinal observational study on 22 MSA patients (11 males and 11 females). Results: Significant changes were obtained in the quantitative SPECT assessments in the three Striatum/Occipital indices. The qualitative SPECT diagnosis did not show differences between the initial and evolving SPECT, but the neurologist’s clinical suspicion did. Our results showed a brain deterioration of around 31% at 12 months, this being the optimal cut-off for differentiating a diseased subject (capable of solving diagnostic error rate). Previous imaging tests were inconclusive, as they showed less deterioration in the SPECT and quantitative assessments with respect to the group of confirmed patients. Repeated SPECT increased the diagnostic sensitivity (50% vs. 75%) and positive predictive value (72.73% vs. 77%). In addition, repeated SPECT proved decisive in the diagnosis of initial inconclusive cases. Conclusion: Repeat SPECT at 12 months proves useful in the diagnosis and follow-up of MSA.

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Valoración cuantitativa del SPECT con FP-CIT. Importancia del área de referencia

Cited by 9 publications

References 12 publications

Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy

Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy

Automatic assistance to Parkinsonˈs disease diagnosis in DaTSCAN SPECT imaging

Follow-Up Findings in Multiple System Atrophy from [123I]Ioflupane Single-Photon Emission Computed Tomography (SPECT): A Prospective Study

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