Valinomycin-stimulated glycolysis in Ehrlich ascites tumor cells

Comparative analysis of the cytotoxicity of substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone]copper(II) chelates

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Seven para-substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone)]copper(II) chelates (12)(13)(14)(15)(16)(17)(18) have been designed, synthesized, and tested for their ability to inhibit the respiration of rat liver slices as a normal cell model and Ehrlich ascites cells as a tumor cell model. Relationships between chemical structure and respiratory inhibition are described on a quantitative basis using substituent constants ( , Es, and ) by computerized multiparameter regression analyses.

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“…These chelates are also capable of inhibiting the respiration of Ehrlich ascites cell suspensions and of rat liver slices. 10 In light of these findings a new series of bis(thiosemicarbazone)copper(II) chelates (12)(13)(14)(15)(16)(17)(18) was designed in an attempt to allow further delineation of the mechanism of action and to allow investigation of possible quantitative relationships between chelate structure and biological activity. The molecules examined in this stage of our investigation contain completely conjugated phenyl rings for the primary purpose of determining the electronic effect of substituents on biological activity.…”