Valinomycin, produced by Streptomyces sp. S8, a key antifungal metabolite in large patch disease suppressiveness

Jeon, Chang-Wook; Kim, Da-Ran; Kwak, Youn‐Sig

doi:10.1007/s11274-019-2704-z

Cited by 14 publications

(16 citation statements)

References 31 publications

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“…For example, valinomycin is a key antifungal metabolite in large patch disease suppressiveness and is produced by Streptomyces sp. S8 (Jeon et al ., 2019). Shuai et al .…”

Section: Resultsmentioning

confidence: 99%

“…For example, valinomycin is a key antifungal metabolite in large patch disease suppressiveness and is produced by Streptomyces sp. S8 (Jeon et al, 2019). Shuai et al isolated a new pyrrolopyrimidine natural product (huimycin) and identified the BGC responsible for its production from the rare actinomycete strain Kutzneria albida DSM 43870 (Shuai et al, 2020).…”

Section: Investigation Of Bacterial Genera With Abundant Amounts Of Bgcsmentioning

confidence: 99%

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An atlas of bacterial secondary metabolite biosynthesis gene clusters

Wei

Zhou

et al. 2021

Environmental Microbiology

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Bacterial secondary metabolites are rich sources of novel drug leads. The diversity of secondary metabolite biosynthetic gene clusters (BGCs) in genomesequenced bacteria, which will provide crucial information for the efficient discovery of novel natural products, has not been systematically investigated.Here, the distribution and genetic diversity of BGCs in 10 121 prokaryotic genomes (across 68 phyla) were obtained from their PRISM4 outputs using a custom python script. A total of 18 043 BGCs are detected from 5743 genomes with non-ribosomal peptide synthetases (25.4%) and polyketides (15.9%) as the dominant classes of BGCs. Bacterial strains harbouring the largest number of BGCs are revealed and BGC count in strains of some genera vary greatly, suggesting the necessity of individually evaluating the secondary metabolism potential. Additional analysis against 102 strains of discovered bacterial genera with abundant amounts of BGCs confirms that Kutzneria, Kibdelosporangium, Moorea, Saccharothrix, Cystobacter, Archangium, Actinosynnema, Kitasatospora, and Nocardia, may also be important sources of natural products and worthy of priority investigation. Comparative analysis of BGCs within these genera indicates the great diversity and novelty of the BGCs. This study presents an atlas of bacterial secondary metabolite BGCs that provides a lot of key information for the targeted discovery of novel natural products.

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“…For example, valinomycin is a key antifungal metabolite in large patch disease suppressiveness and is produced by Streptomyces sp. S8 (Jeon et al ., 2019). Shuai et al .…”

Section: Resultsmentioning

confidence: 99%

Section: Investigation Of Bacterial Genera With Abundant Amounts Of Bgcsmentioning

confidence: 99%

An atlas of bacterial secondary metabolite biosynthesis gene clusters

Wei

Zhou

et al. 2021

Environmental Microbiology

View full text Add to dashboard Cite

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“…However, the extensive use of agrochemicals has caused pernicious pesticide residues and environmental pollution, declined crop quality, and threatened human health. Innovative and ground-breaking strategies are therefore urgently required to control the plant viral pathogens and improve grain output because of the growing world population [2,3].…”

Section: Backgroudmentioning

confidence: 99%

“…Biological control with endophytic strains is a promising measure to control plant diseases and eliminate pollution at the same time [4,5]. In most cases, endophytes can produce bioactive secondary metabolites to inhibit pathogens, such as bacteria, fungi, and insects, or improve the resistance to pathogens [3,6,7]. The application of endophytes in biocontrol is limited because of unclear mechanism and exceptional growth condition [8].…”

Section: Backgroudmentioning

confidence: 99%

Ultrahigh-activity immune inducer from Endophytic Fungi induces tobacco resistance to virus by SA pathway and RNA silencing

et al. 2020

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Background: Plant viruses cause severe economic losses in agricultural production. An ultrahigh activity plant immune inducer (i.e., ZhiNengCong, ZNC) was extracted from endophytic fungi, and it could promote plant growth and enhance resistance to bacteria. However, the antiviral function has not been studied. Our study aims to evaluate the antiviral molecular mechanisms of ZNC in tobacco. Results: Here, we used Potato X virus (PVX), wild-type tobacco and NahG transgenic tobacco as materials to study the resistance of ZNC to virus. ZNC exhibited a high activity in enhancing resistance to viruses and showed optimal use concentration at 100-150 ng/mL. ZNC also induced reactive oxygen species accumulation, increased salicylic acid (SA) content by upregulating the expression of phenylalanine ammonia lyase (PAL) gene and activated SA signaling pathway. We generated transcriptome profiles from ZNC-treated seedlings using RNA sequencing. The first GO term in biological process was positive regulation of post-transcriptional gene silencing, and the subsequent results showed that ZNC promoted RNA silencing. ZNC-sprayed wild-type leaves showed decreased infection areas, whereas ZNC failed to induce a protective effect against PVX in NahG leaves. Conclusion: All results indicate that ZNC is an ultrahigh-activity immune inducer, and it could enhance tobacco resistance to PVX at low concentration by positively regulating the RNA silencing via SA pathway. The antiviral mechanism of ZNC was first revealed in this study, and this study provides a new antiviral bioagent.

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“…Colletotrichum gloeosporioides is widely distributed in tropical and subtropical regions and can infect mango, peaches, Liriodendron chinense × tulipifera, Cunninghamia lanceolata, and Camellia sinensis, causing anthracnose in leaves and fruits (Huang et al, 2018;Tang et al, 2019;Wu et al, 2019;Zhu et al, 2019;Shang et al, 2020). The conidia of this pathogen can infect the tender leaves, twigs, flowers and fruits of the host, causing leaves, flowers and fruits to fall, and fruit to decay during storage, resulting in serious economic losses.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Effects of Volatile Organic Compounds Produced by Rahnella aquatilis JZ-GX1 Against Colletotrichum gloeosporioides in Liriodendron chinense × tulipifera

Kong

Lin

et al. 2020

Front. Microbiol.

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The use of volatile organic compounds (VOCs) produced by microorganisms for the biological control of plant diseases has attracted much attention in recent years. In this study, the antifungal activity and identity of VOCs produced by Rahnella aquatilis JZ-GX1 isolated from the rhizosphere soil of pine were determined and analyzed. The effect of the VOCs on the mycelial growth of Colletotrichum gloeosporioides, the pathogen of Liriodendron chinense × tulipifera black spot, was determined by a joined-petri dish fumigation method. An in vitro leaf inoculation method was used to determine the fumigation effect of the VOCs on Liriodendron black spot. VOCs with antifungal activity were collected by headspace solid-phase microextraction (SPME), and their components were analyzed by gas chromatography-mass spectrometry (GC-MS). The results showed that the VOCs secreted by JZ-GX1 inhibited the mycelial growth of the tested pathogen. The VOCs destroyed the morphology of the mycelium, significantly increased the permeability of the cell membrane and downregulated the expression of pathogenicity-related genes during mycelial infection, thus inhibiting the expansion of anthracnose disease spots in leaves. In the volatile compound profile, 3-methyl-1-butanol and 2-phenylethyl methyl ether significantly inhibited the mycelial growth and spore germination of C. gloeosporioides. This work provides a new strategy for the research and application of microorganisms and bioactive compounds to control plant anthracnose.

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Valinomycin, produced by Streptomyces sp. S8, a key antifungal metabolite in large patch disease suppressiveness

Cited by 14 publications

References 31 publications

An atlas of bacterial secondary metabolite biosynthesis gene clusters

An atlas of bacterial secondary metabolite biosynthesis gene clusters

Ultrahigh-activity immune inducer from Endophytic Fungi induces tobacco resistance to virus by SA pathway and RNA silencing

Antifungal Effects of Volatile Organic Compounds Produced by Rahnella aquatilis JZ-GX1 Against Colletotrichum gloeosporioides in Liriodendron chinense × tulipifera

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