Valine Supplementation in a Reduced Protein Diet Regulates Growth Performance Partially through Modulation of Plasma Amino Acids Profile, Metabolic Responses, Endocrine, and Neural Factors in Piglets

Zhang, Xiaoya; Liu, Xutong; Jia, Haiyan; He, Pingli; Mao, Xiangbing; Qiao, Shiyan; Zeng, Xiangfang

doi:10.1021/acs.jafc.8b01113

Cited by 21 publications

(25 citation statements)

References 35 publications

(56 reference statements)

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“…This can be due to reduced FI, increased EE and altered metabolism of BCAA and gut microbiota composition in pigs fed with VLP diets 33 . Although previous research has provided evidence on beneficial effects of supplemental BCAA on growth of nursery and growing pigs fed with diets with normal 31,32 or slightly low protein content 19,22,23,[25][26][27][28][29][30]39 diets, little is understood whether supplementing VLP diets with BCAA can partially or completely recover the VLP induced depression of growth performance. In the current study, supplementing VLP diets with BCAA at levels recommended by Nutrient Requirements of Swine 8 delayed the onset of reduction in BW in nursery pigs.…”

Section: Discussionmentioning

confidence: 99%

“…Supplementation of slightly low protein diets (17% crude protein [CP]) with all BCAA improved the growth performance of nursery 22 – 26 and growing 27 pigs. Dietary deficiency of valine decreased the average daily feed intake (ADFI) and growth performance of weaned pigs 17 and supplementing slightly protein deprived diets with isoleucine and valine protected nursery and growing pigs against reduction in feed intake (FI) and body weight (BW) 7 , 19 , 28 – 30 . Further, the average daily gain (ADG) was increased with increasing the standard ileal digestibility (SID) valine:lysine in standard protein diets of nursery 31 and growing pigs 32 .…”

Section: Introductionmentioning

confidence: 99%

“…Previous research has shown that BCAA improve the growth performance of pigs fed with slightly low protein diets likely through improvement in metabolic profile in liver and muscle 28,35 , oxidative capacity of muscle 36 , plasma concentration of BCAA 22 , intestinal morphology and cell proliferation 37 , and protein metabolism and muscle growth 21,27,38 . Little is known about the effect of VLP diets supplemented with BCAA on energy balance as well as the mechanisms by which these diets influence the growth performance of nursery pigs.…”

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confidence: 99%

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Effect of very low-protein diets supplemented with branched-chain amino acids on energy balance, plasma metabolomics and fecal microbiome of pigs

Spring

Premathilake

Bradway

et al. 2020

Sci Rep

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Feeding pigs with very-low protein (VLP) diets while supplemented with limiting amino acids (AA) results in decreased growth. The objective of this study was to determine if supplementing VLP diets with branched-chain AA (BCAA) would reverse the negative effects of these diets on growth and whether this is associated with alterations in energy balance, blood metabolomics and fecal microbiota composition. Twenty-four nursery pigs were weight-matched, individually housed and allotted into following treatments (n = 8/group): control (CON), low protein (LP) and LP supplemented with BCAA (LP + BCAA) for 4 weeks. Relative to CON, pigs fed with LP had lower feed intake (FI) and body weight (BW) throughout the study, but those fed with LP + BCAA improved overall FI computed for 4 weeks, tended to increase the overall average daily gain, delayed the FI and BW depression for ~ 2 weeks and had transiently higher energy expenditure. Feeding pigs with LP + BCAA impacted the phenylalanine and protein metabolism and fatty acids synthesis pathways. Compared to CON, the LP + BCAA group had higher abundance of Paludibacteraceae and Synergistaceae and reduced populations of Streptococcaceae, Oxyphotobacteria_unclassified, Pseudomonadaceae and Shewanellaceae in their feces. Thus, supplementing VLP diets with BCAA temporarily annuls the adverse effects of these diets on growth, which is linked with alterations in energy balance and metabolic and gut microbiome profile.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Effect of very low-protein diets supplemented with branched-chain amino acids on energy balance, plasma metabolomics and fecal microbiome of pigs

Spring

Premathilake

Bradway

et al. 2020

Sci Rep

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“…Moreover, fermented corn-soybean meal in our study improved daily gain by 40%, and shortened the time to market by 20 d, indicating fermented meal dramatically promoted pig growth. Based on the well-documented effects of Val (Zhang et al, 2018) or Arg (Hu et al, 2017) on pig growth, we speculate that the increased supply of functional amino acids might contribute to the growth-promoting effects of FF.…”

Section: Discussionmentioning

confidence: 90%

Fermented corn-soybean meal elevated IGF1 levels in grower-finisher pigs1

Fan

Dou

Wang

et al. 2018

Journal of Animal Science

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Fermentation has attracted increasing attention in pig industry, because of low costs and numerous benefits on pig growth and health as well as environmental improvement, although the mechanisms remain largely unknown. In the present study, fermented corn-soybean meal significantly improved average daily gain and gain:food ratio (P < 0.05). Fermented feed (FF) significantly increased insulin-like growth factor 1 (IGF1) transcription in liver (P < 0.05). Meanwhile, fermented meal significantly enhanced the binding of CCAAT/enhancer-binding protein beta (C/EBPβ) to IGF1 promoter and C/EBPβ expression in liver (both P < 0.05). FF tended to increase IGF1 proteins in liver and serum too (both 0.05 < P < 0.10). Meanwhile, FF slightly but significantly increased hepatic and circulating triglyceride and total cholesterol levels, as well as serum ratio of high-density to low-density cholesterol (all P < 0.05). Our data indicated that FF could significantly augment the binding of C/EBPβ to IGF1 promoter and promote hepatic IGF1 expression and production, thus boost pig growth.

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“…Another possibility is that the valine to lysine ratio was higher in CD (0.94) than PD (0.85). Study showed that when the valine to lysine ratio was higher, the concentration of leucine and isoleucine was lower at 40 min after feed intake [31]. Because BCAAs share the same enzymes to compete for transamination and oxidative decarboxylation catalysis [30].…”

Section: Discussionmentioning

confidence: 99%

Dynamic changes of postprandial plasma metabolites after intake of corn-soybean meal or casein-starch diets in growing pigs

Huang

et al. 2019

J Animal Sci Biotechnol

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Background Postprandial nutrients utilization and metabolism of a certain diet is a complicated process. The metabolic feature of pigs after intake of corn-soybean meal or casein-starch diets are largely unknown. Therefore, this study was conducted to investigate the dynamic postprandial changes of plasma metabolic profile using growing pigs using metabolomics. Methods Twenty-four growing pigs with average initial body weight (BW) about 30 kg were placed in metabolic cages and then fitted with precaval vein catheters. Pigs were fed daily 4% of initial body weight. Two experimental diets were included: (i) a starch-casein based purified diet (PD) and (ii) a common corn-soybean meal diet (CD). Plasma was collected before feeding and 0.5 h, 1 h, 2 h, 4 h, 8 h after feeding. Results In both diets, compared to prior to feeding, the concentrations of glucose, most amino acids, metabolites such as 5-aminopentanoic acid, pipecolic acid, ornithine and 5-hydroxy- L -tryptophan were significantly increased in plasma during the first hour, whereas the concentrations of plasma triglycerides, glutamate, glycine, palmitelaidic acid, 13-HODE and oleic acid were decreased in the first hour. Compared with PD group, concentration of plasma leucine and isoleucine declined at 30 min in CD group. Plasma linoleic acid, sphingosine and many dipeptides were significantly higher in pigs fed CD. Conclusion Most significant metabolic changes occurred during the first hour after feeding and then became relatively stable after 2 h in both diets. These results show a broad scope picture of postprandial changes in plasma metabolites after intake of PD and CD and could be a reference for further nutrition intervention as well as the design of nutritional studies. Electronic supplementary material The online version of this article (10.1186/s40104-019-0351-8) contains supplementary material, which is available to authorized users.

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Valine Supplementation in a Reduced Protein Diet Regulates Growth Performance Partially through Modulation of Plasma Amino Acids Profile, Metabolic Responses, Endocrine, and Neural Factors in Piglets

Cited by 21 publications

References 35 publications

Effect of very low-protein diets supplemented with branched-chain amino acids on energy balance, plasma metabolomics and fecal microbiome of pigs

Effect of very low-protein diets supplemented with branched-chain amino acids on energy balance, plasma metabolomics and fecal microbiome of pigs

Fermented corn-soybean meal elevated IGF1 levels in grower-finisher pigs1

Dynamic changes of postprandial plasma metabolites after intake of corn-soybean meal or casein-starch diets in growing pigs

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