Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis

Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population

“…However, the possible mechanism by which the Ala-9Val polymorphism might modify liver disease risk by alcohol consumption has been described in the literature [17][18][19]. Nahon et al [19] found that the presence of at least one Ala allele increased the risk of cirrhosis in French alcoholics.…”

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies

“…SOD2 rs4880 genotyping SOD2 genotype was determined by PCR-RFLP analysis using a minor modification of our previously described method [26]. The final volume (20 ll) of the PCR reaction contained 0.5-1 lg genomic DNA, 0.625 U Taq DNA polymerase, 1Â Taq DNA polymerase reaction buffer (50 mM potassium chloride, 10 mM Tris-HCl pH 9.0, 0.1% (v/v) Triton X-100, 1.5 mM MgCl 2 ), 0.1 mM dNTPs and 0.25 lM both forward and reverse primers (5 0 -CAGCCCAGCCTGCGTAGACGG-3 0 and 5 0 -GCGCGTTGATG TGAGGTTCCAG-3 0 ).…”

“…More recently, the homozygous T genotype was reported to be associated with an increased incidence of diabetic nephropathy in large studies of type 1 diabetics from Sweden [22] and Denmark [23] and with susceptibility to pancreatic cancer in a USbased study [24]. SOD2 has also been investigated in relation to susceptibility to alcoholic liver disease but the results have been inconsistent and inconclusive [25,26].…”

MnSOD Overexpression Prevents Liver Mitochondrial DNA Depletion after an Alcohol Binge but Worsens This Effect after Prolonged Alcohol Consumption in Mice

“…The role of this dimorphism in the susceptibility of alcoholic patients to develop ALD is controversial [30,31,32], and its influence on the occurrence of hepatocellular carcinoma (HCC) and death in patients with alcoholic cirrhosis has been described [31]. The presence of at least 1 Ala MnSOD allele increases the risk for developing cirrhosis in alcoholics, and increases the rates of HCC development and death in cirrhotic patients [31].…”