Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation

Chen, Po‐Yu; Lin, Keh‐chung; Liing, Rong-Jiuan; Wu, Ching‐yi; Chen, Chia‐Ling; Chang, Ku‐Chou

doi:10.1007/s11136-015-1196-z

Cited by 137 publications

(107 citation statements)

References 52 publications

Supporting

Mentioning

101

Contrasting

Order By: Relevance

“…Similarly, being exposed to a DBI medication and a PIM was associated with a decrease of 0.034 DEMQOL-SelfReport-Utility score compared to not being exposed to a DBI medication or PIM. The precise clinically meaningful difference in the quality of life scores used in this study population remains unclear, but previous literature has suggested a clinically meaningful difference in such utility measures may be in the range of 0.03 to 0.10 depending on the population being studied [22][23][24]. This would suggest that many of the associations seen in this study between the number of PIMs a participant was exposed to and quality of life utility measures may not be clinically meaningful (between 0.020 and 0.030 difference in quality of life with exposure to an additional PIM); however, the cumulative impact of multiple PIMs may be clinically significant.…”

Section: Discussionmentioning

confidence: 99%

Associations between the Drug Burden Index, Potentially Inappropriate Medications and Quality of Life in Residential Aged Care

et al. 2018

View full text Add to dashboard Cite

Background: Inappropriate polypharmacy may negatively impact quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life.Objective: The objective was to examine whether the Drug Burden Index (DBI) and potentially inappropriate medications (PIMs), were associated with quality of life in older adults living in residential care with a high prevalence of cognitive impairment and dementia.Methods: Cross-sectional analyses of 541individuals recruited from 17 residential aged care facilities in Australia in the Investigating Services Provided in the Residential Environment for Dementia (INSPIRED) study. Quality of life was measured using the EQ-5D-5L (a measure of generic quality of life) and the DEMQOL (a measure developed for use in dementia) completed by the participant or a proxy.Results: In the 100 days prior to recruitment, 83.1% of the participants received at least one anticholinergic or sedative medication included in the DBI and 82.7% received at least one PIM according to the Beers Criteria. Multi-level linear models showed there was a significant association between higher DBI and lower quality of life according to the EQ-5D-5L (β (SE): -0.034 (0.012), p=0.006) after adjustment for potential confounding factors. Increasing numbers of PIMs were also associated with lower EQ-5D-5L scores (-0.030 (0.010), p=0.003) and DEMQOL-Self-Report-Utility scores (-0.020 (0.009), p=0.029). Exposure to both DBI-associated medications and PIMs was associated with lower DEMQOL-SelfReport-Utility scores (-0.034 (0.017), p=0.049).Conclusion: Exposure to anticholinergic and sedative medications and PIMs occurred in over three-quarters of a population of older adults in residential care and was associated with a lower quality of life.  This study provides evidence to support that there is a need for greater adherence to recommendations for appropriate medication use in residential aged care.

show abstract

Section: Discussionmentioning

confidence: 99%

Associations between the Drug Burden Index, Potentially Inappropriate Medications and Quality of Life in Residential Aged Care

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Although there is no consensus, changes in the EQ-5D utility index and WEMWBS of 0.10 [24] and between 3 and 8 points [25], respectively, have been recommended as clinically important. In this trial, we observed that scores on these questionnaires were, on average, 0.12 and 6 points higher, respectively, in the Yoga group at 3 months.…”

Section: Discussionmentioning

confidence: 99%

Adapted yoga to improve physical function and health-related quality of life in physically-inactive older adults: a randomised controlled pilot trial

Tew

Howsam²,

Hardy

et al. 2017

BMC Geriatr

View full text Add to dashboard Cite

BackgroundYoga is a holistic therapy of expanding popularity, which has the potential to produce a range of physical, mental and social benefits. This trial evaluated the feasibility and effects of an adapted yoga programme on physical function and health-related quality of life in physically-inactive older adults.MethodsIn this randomised controlled pilot trial, 52 older adults (90% female; mean age 74.8 years, SD 7.2) were randomised 1:1 to a yoga programme or wait-list control. The yoga group (n = 25) received a physical activity education booklet and were invited to attend ten yoga sessions during a 12-week period. The control group (n = 27) received the education booklet only. Measures of physical function (e.g., Short Physical Performance Battery; SPPB), health status (EQ-5D) and mental well-being (Warwick-Edinburgh Mental Well-being Scale; WEMWBS) were assessed at baseline and 3 months. Feasibility was assessed using course attendance and adverse event data, and participant interviews.ResultsForty-seven participants completed follow-up assessments. Median class attendance was 8 (range 3 to 10). At the 3-month follow-up, the yoga group had a higher SPPB total score compared with the control group (mean difference 0.9, 95% confidence interval [CI] -0.3 to 2.0), a faster time to rise from a chair five times (mean difference − 1.73 s, 95% CI −4.08 to 0.62), and better performance on the chair sit-and-reach lower-limb flexibility test (mean difference 5 cm, 95% CI 0 to 10). The yoga group also had superior health status and mental well-being (vs. control) at 3 months, with mean differences in EQ-5D and WEMWBS scores of 0.12 (95% CI, 0.03 to 0.21) and 6 (95% CI, 1 to 11), respectively. The interviews indicated that participants valued attending the yoga programme, and that they experienced a range of benefits.ConclusionsThe adapted yoga programme appeared to be feasible and potentially beneficial in terms of improving mental and social well-being and aspects of physical function in physically-inactive older adults. An appropriately-powered trial is required to confirm the findings of the present study and to determine longer-term effects.Trial registration ClinicalTrials.gov NCT02663726.

show abstract

“…Interestingly, MFS improvement patterns paralleled those of X A , and strong correlations were demonstrated between active function and composite active motion at each visit. Yet, these functional improvements were paralleled by positive but small changes in SF-36 and EQ-5D scores, 44,45 which could suggest functional upper limb changes of a greater magnitude may be needed for a meaningful impact on quality of life or perceived health scores. Overall, the results of the present study seem more positive than those obtained by Shaw et al or Lagalla et al, 19,20 which may be due to a number of factors, including the electrical stimulation localization method systematically used to target muscles in our study, overall doses injected, and the outcome measures used.…”

Section: Improvement Of Perceived and Active Function Acrossmentioning

confidence: 99%

Effects of repeated abobotulinumtoxinA injections in upper limb spasticity

et al. 2017

View full text Add to dashboard Cite

Introduction: The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500‐U dose included 500‐U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment‐emergent adverse events (TEAEs), muscle tone, passive and active range of motion (XV1, XA), angle of catch (XV3), Disability Assessment Scale (DAS) score, Modified Frenchay Scale (MFS) score, and Physician Global Assessment (PGA) score. Results: The incidence of TEAEs decreased across cycles. Muscle tone reduction and XV1 remained stable across cycles, whereas XV3 and XA continued to improve at the finger, wrist, and elbow flexors. DAS and PGA improved across cycles. MFS improved best with 1,500 U. Discussion: A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limb muscles. Muscle Nerve 57: 245–254, 2018

show abstract

Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation

Cited by 137 publications

References 52 publications

Associations between the Drug Burden Index, Potentially Inappropriate Medications and Quality of Life in Residential Aged Care

Associations between the Drug Burden Index, Potentially Inappropriate Medications and Quality of Life in Residential Aged Care

Adapted yoga to improve physical function and health-related quality of life in physically-inactive older adults: a randomised controlled pilot trial

Effects of repeated abobotulinumtoxinA injections in upper limb spasticity

Contact Info

Product

Resources

About